Type IV Gastric Carcinoids in the Stomach Caused by ATP4A Gene Mutations. | Type IV Gastric Carcinoids in the Stomach Caused by ATP4A Gene Mutations. Ihara Y, Umeno J, Hori Y. | 09/18/2021 |
ATP4A antibodies were present in a significant proportion of children with type 1 diabetes (T1D). Higher ATP4A levels in T1D children are associated with lower, yet still fitting within the normal range, levels of vitamin B12, and ferritin. | ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12. Chobot A, Rusak E, Wenzlau J, Davidson H, Adamczyk P, Krzywicka A, Mazur B, Polańska J, Rewers M. | 10/20/2018 |
Heterozygous mutations in the ATP4A and PTH1R genes were identified in a family with type I gastric neuroendocrine tumors plus hypothyroidism and rheumatoid arthritis | A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis. Calvete O, Herraiz M, Reyes J, Patiño A, Benitez J. | 06/16/2018 |
the generation and characterization of a knockin mouse model for the ATP4a(R703C) mutation to better understand the tumorigenesis process. | A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies. Calvete O, Varro A, Pritchard DM, Barroso A, Oteo M, Morcillo MÁ, Vargiu P, Dodd S, Garcia M, Reyes J, Ortega S, Benitez J., Free PMC Article | 12/9/2017 |
In conclusion, patients homozygous for an inactivating ATP4A mutation develop gastric ECL-cell carcinoids in their 3rd or 4th decade. | ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit. Fossmark R, Calvete O, Mjønes P, Benitez J, Waldum HL. | 01/28/2017 |
Homozygous missense mutation in the 14th exon of the ATP4A gene (c.2107C>T) is responsible for an atypical familial type I gastric neuroendocrine tumour. | Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour. Calvete O, Reyes J, Zuñiga S, Paumard-Hernández B, Fernández V, Bujanda L, Rodriguez-Pinilla MS, Palacios J, Heine-Suñer D, Banka S, Newman WG, Cañamero M, Pritchard DM, Benítez J. | 01/30/2016 |
ATP4A are found in nearly one-third of children with type 1 diabetes and more common among females. In this cross-sectional analysis, Hp infection was not associated with autoimmunity against parietal cells. | ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes. Chobot A, Wenzlau J, Bak-Drabik K, Kwiecien J, Polanska J, Rewers M., Free PMC Article | 09/27/2014 |
Downregulation of ATP4A gene is associated with gastric cancer. | Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker. Raja UM, Gopal G, Rajkumar T. | 07/6/2013 |
cigarette smoke extract may cause an increase in the amount and activity of H,K-ATPase and smokers' susceptibility to development of peptic ulcer | Dysregulation of gastric H,K-ATPase by cigarette smoke extract. Hammadi M, Adi M, John R, Khoder GA, Karam SM., Free PMC Article | 01/21/2010 |
study concludes that IL-1beta upregulates HKalpha transcription by inducing Sp1 binding to HKalpha Sp1 & NF-kappaB sites & that Helicobacter pylori perturbation of HKalpha expression is independent of Sp1-mediated basal HKalpha transcription | The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription. Saha A, Hammond CE, Gooz M, Smolka AJ., Free PMC Article | 01/21/2010 |
Gastric H+/K+-ATPase activities are not associated with H pylori status in patients with chronic gastritis. | Direct measurement of gastric H+/K+-ATPase activities in patients with or without Helicobacter pylori-associated chronic gastritis. Thong-Ngam D, Tangkijvanich P, Sampatanukul P, Prichakas P, Mahachai V, Tosukowong P., Free PMC Article | 01/21/2010 |