| Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane. | Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane.
Jia H, Zhou LC, Chen YF, Zhang W, Qi W, Wang P, Huang X, Guo JW, Hou WF, Zhang RR, Zhou JJ, Zhang DW., Free PMC Article | 11/5/2024 |
| Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class. | Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.
D'Amico F, Mukhopadhyay R, Ovaa H, Mulder MPC., Free PMC Article | 04/26/2024 |
| TRIM proteins trim the balance of homoeostasis by modulating various biological pathways through protein-protein interactions. | TRIM proteins as trim tabs for the homoeostasis.
Horie-Inoue K. | 04/26/2024 |
| MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats. | MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats.
Zhu XZ, Wang JQ, Wu YH. | 06/5/2023 |
| Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway. | Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway.
Cai M, Gao X, Yu S. | 02/24/2023 |
| Cryo-EM structure of human MG53 homodimer. | Cryo-EM structure of human MG53 homodimer.
Niu Y, Chen G, Lv F, Xiao RP, Hu X, Chen L. | 10/1/2022 |
| MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis. | MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis.
Cui KM, Hu ZP, Wang YL. | 08/6/2022 |
| Ubiquitination and degradation of MGMT by TRIM72 increases the sensitivity of uveal melanoma cells to Dacarbazine treatment. | Ubiquitination and degradation of MGMT by TRIM72 increases the sensitivity of uveal melanoma cells to Dacarbazine treatment.
Li X, Yang C, Luo N, Yang Y, Guo Y, Chen P, Cun B. | 06/11/2022 |
| TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA. | TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
Wang Z, Li H, Wang H, Li X, Zhang Q, Wang H, Li K, Qiu Y., Free PMC Article | 04/23/2022 |
| MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. | MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
Li H, Lin PH, Gupta P, Li X, Zhao SL, Zhou X, Li Z, Wei S, Xu L, Han R, Lu J, Tan T, Yang DH, Chen ZS, Pawlik TM, Merritt RE, Ma J., Free PMC Article | 01/29/2022 |
| MG53/CAV1 regulates transforming growth factor-beta1 signaling-induced atrial fibrosis in atrial fibrillation. | MG53/CAV1 regulates transforming growth factor-β1 signaling-induced atrial fibrosis in atrial fibrillation.
Zhang M, Wang H, Wang X, Bie M, Lu K, Xiao H., Free PMC Article | 12/11/2021 |
| Functional and Adaptive Significance of Promoter Mutations That Affect Divergent Myocardial Expressions of TRIM72 in Primates. | Functional and Adaptive Significance of Promoter Mutations That Affect Divergent Myocardial Expressions of TRIM72 in Primates.
Feng Y, Xu H, Liu J, Xie N, Gao L, He Y, Yao Y, Lv F, Zhang Y, Lu J, Zhang W, Li CY, Hu X, Yang Z, Xiao RP., Free PMC Article | 11/13/2021 |
| MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle. | MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle.
Philouze C, Turban S, Cremers B, Caliez A, Lamarche G, Bernard C, Provost N, Delerive P., Free PMC Article | 07/31/2021 |
| TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma. | TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma.
Fernández-Aceñero MJ, Cruz M, Sastre-Varela J, Casal JI, Nieto MAC, Del Puerto-Nevado L, García-Foncillas J, Cebrián A. | 04/3/2021 |
| TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis. | TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis.
Cong X, Nagre N, Herrera J, Pearson AC, Pepper I, Morehouse R, Ji HL, Jiang D, Hubmayr RD, Zhao X., Free PMC Article | 04/3/2021 |
| MG53 suppresses interferon-beta and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. | MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling.
Sermersheim M, Kenney AD, Lin PH, McMichael TM, Cai C, Gumpper K, Adesanya TMA, Li H, Zhou X, Park KH, Yount JS, Ma J., Free PMC Article | 09/12/2020 |
| MG53 enhances the efficacy of hUC-MSCs in the recovery of TBI, indicating that such adjunctive therapy may provide a novel strategy to lessen damage and optimize recovery for brain injury. | The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury.
Guan F, Huang T, Wang X, Xing Q, Gumpper K, Li P, Song J, Tan T, Yang GL, Zang X, Zhang J, Wang Y, Yang Y, Liu Y, Zhang Y, Yang B, Ma J, Ma S., Free PMC Article | 07/25/2020 |
| CRIg is a novel interacting partner of TRIM72 in the lung. | Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Nagre N, Cong X, Terrazas C, Pepper I, Schreiber JM, Fu H, Sill JM, Christman JW, Satoskar AR, Zhao X., Free PMC Article | 07/27/2019 |
| serum TRIM72 may be a potential biomarker for the diagnosis and the prognosis of colon cancer. | Serum Levels of TRIM72 Are Lower among Patients with Colon Cancer: Identification of a Potential Diagnostic Marker.
Chen Z, Yin X, Li K, Chen S, Li H, Li Y, Zhang Q, Wang H, Qiu Y. | 10/6/2018 |
| MG53 is an effective biomarker of myocardial injury and dysfunction in murine hearts. However, MG53 is not expressed in human heart and therefore does not hold utility as a clinical biomarker of myocardial injury | Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor.
Lemckert FA, Bournazos A, Eckert DM, Kenzler M, Hawkes JM, Butler TL, Ceely B, North KN, Winlaw DS, Egan JR, Cooper ST., Free PMC Article | 01/28/2017 |
| MG53 is a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing | Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair.
Li H, Duann P, Lin PH, Zhao L, Fan Z, Tan T, Zhou X, Sun M, Fu M, Orange M, Sermersheim M, Ma H, He D, Steinberg SM, Higgins R, Zhu H, John E, Zeng C, Guan J, Ma J., Free PMC Article | 01/16/2016 |
| Zn(2+) interacts with MG53 in protection against injury to the cell membrane | Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes.
Cai C, Lin P, Zhu H, Ko JK, Hwang M, Tan T, Pan Z, Korichneva I, Ma J., Free PMC Article | 08/22/2015 |
| MG53 induces FAK ubiquitination with the aid of UBE2H during skeletal myogenesis. | Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis.
Nguyen N, Yi JS, Park H, Lee JS, Ko YG., Free PMC Article | 04/12/2014 |
| MG53/TRIM72 protein can be directly applied as a therapeutic agent to increase membrane repair capacity of many cell types. | TRIM proteins in therapeutic membrane repair of muscular dystrophy.
Alloush J, Weisleder N., Free PMC Article | 09/21/2013 |
| data reveal NM-IIA as a key cytoskeleton motor protein that facilitates vesicle trafficking during MG53-mediated cell membrane repair | Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.
Lin P, Zhu H, Cai C, Wang X, Cao C, Xiao R, Pan Z, Weisleder N, Takeshima H, Ma J., Free PMC Article | 06/30/2012 |