| Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells. | Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells.
Makise M, Uchimura R, Higashi K, Mashiki Y, Shiraishi R, Shutoku Y, Kuniyasu A., Free PMC Article | 03/12/2022 |
| Loss of Nup88 inhibited nuclear export of recombination signal-binding protein for immunoglobulin kappaJ region (RBP-J), the DNA-binding component of the Notch pathway. | The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.
Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C., Free PMC Article | 03/21/2020 |
| Here we report biallelic mutations in the nucleoporin NUP88 as a novel cause of lethal fetal akinesia deformation sequence (FADS) in two families. We demonstrate that NUP88 depletion affects rapsyn, a key regulator of the muscle nicotinic acetylcholine receptor at the neuromuscular junction. | Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.
Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B., Free PMC Article | 03/9/2019 |
| Study in HeLa cells revealed that Nup88 can affect the phosphorylation status of vimentin, which may contribute to the Nup88-dependent multinucleated phenotype through changing the organization of vimentin. | The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype.
Makise M, Nakamura H, Kuniyasu A., Free PMC Article | 01/19/2019 |
| Overexpression of the NUP88 is associated with cancer. | Multiple biological processes may be associated with tumorigenesis under NUP88-overexpressed condition.
Li J, Zhao J, Li Y. | 07/22/2017 |
| Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions | Can Nup88 expression be associated with atypical endometrial hyperplasia and endometrial cancer? A preliminary study.
Li Y, Zhang X, Ge J, Liu X, Xu S, Zhu Z, Fang G, Liu J, Zhang H, Sun X. | 01/28/2017 |
| These findings demonstrate that the NUP88-NUP98-RAE1-APC/CCDH1 axis contributes to aneuploidy | Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.
Naylor RM, Jeganathan KB, Cao X, van Deursen JM., Free PMC Article | 07/16/2016 |
| Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. | Quantitative regulation of nuclear pore complex proteins by O-GlcNAcylation.
Mizuguchi-Hata C, Ogawa Y, Oka M, Yoneda Y. | 03/1/2014 |
| Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of colorectal cancer | Increased serum level of Nup88 protein is associated with the development of colorectal cancer.
Zhao ZR, Zhang LJ, Wang YY, Li F, Wang MW, Sun XF. | 06/15/2013 |
| Nup88 mRNA was overexpressed in colorectal cancers and the overexpression was associated with cancer development and aggressiveness. | Nup88 mRNA overexpression in colorectal cancers and relationship with p53.
Zhao ZR, Zhang ZY, He XQ, Hu YM, Tian YF, Zhang LJ, Sun XF. | 12/31/2011 |
| Data suggest that a pool of Nup88 on the nuclear side of the nuclear pore complex provides a novel, unexpected binding site for nuclear lamin A. | The nucleoporin Nup88 is interacting with nuclear lamin A.
Lussi YC, Hügi I, Laurell E, Kutay U, Fahrenkrog B., Free PMC Article | 12/10/2011 |
| association found between myometrial invasion and Nup88 expression in endometrial carcinoma | Nup88 expression is associated with myometrial invasion in endometrial carcinoma.
Schneider J, Martínez-Arribas F, Torrejón R. | 01/1/2011 |
| Gambogic acid exerts its anti-leukemia effects by regulating the expression and distribution of nucleoporin Nup88. | Effects of gambogic acid on the regulation of nucleoporin Nup88 in U937 cells.
Shu W, Chen Y, He J, Cui G. | 10/30/2010 |
| proper expression of Nup88 is critical for preventing aneuploidy formation and tumorigenesis. | Characterization of the role of the tumor marker Nup88 in mitosis.
Hashizume C, Nakano H, Yoshida K, Wong RW., Free PMC Article | 08/2/2010 |
| Nup88 is significantly overexpressed in high-grade CIN lesions and ISCC compared with normal ectocervical squamous epithelia and CIN1. | Nucleoporin 88 expression in normal and neoplastic squamous epithelia of the uterine cervix.
Brustmann H, Hager M. | 01/21/2010 |
| The antitumor activity of deguelin was related to up-regulating the expression of Nup98 and down-regulating Nup88 protein. | [Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro].
Chen Y, Liu HL, Cui GH, Wu QL, He J, Chen WH. | 01/21/2010 |
| Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes. | Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus.
Andres-Hernando A, Lanaspa MA, Rivard CJ, Berl T., Free PMC Article | 01/21/2010 |
| The formation of high molecular mass complexes containing importin-alpha, Nup153 and Nup88 is increased upon oxidant treatment. | Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes.
Kodiha M, Tran D, Qian C, Morogan A, Presley JF, Brown CM, Stochaj U. | 01/21/2010 |
| the Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export | Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export.
Bernad R, Engelsma D, Sanderson H, Pickersgill H, Fornerod M. | 01/21/2010 |
| High Nup88 mRNA expression levels correlated with ductal and tubular histology, nuclear grade 3, absence of hormone receptors, expression of c-erb-B2 oncogene and mutant p53 protein, high proliferation, DNA aneuploidy, and axillary node invasion. | Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer.
Agudo D, Gómez-Esquer F, Martínez-Arribas F, Núñez-Villar MJ, Pollán M, Schneider J. | 01/21/2010 |
| A monoclonal antibody for Nup88 in an experimental model for studying the role played by Nup88 during cell development and differentiation. | Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human tumors.
Schneider J, Linares R, Martínez-Arribas F, Moragues MD, Nuñez-Villar MJ, Palomar MA, Pontón J. | 01/21/2010 |
| Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases.
Knoess M, Kurz AK, Goreva O, Bektas N, Breuhahn K, Odenthal M, Schirmacher P, Dienes HP, Bock CT, Zentgraf H, zur Hausen A., Free PMC Article | 01/21/2010 |