| DDR2 expression in breast cancer is associated with blood vessel invasion, basal-like tumors, tumor associated macrophages, regulatory T cells, detection mode and prognosis. | DDR2 expression in breast cancer is associated with blood vessel invasion, basal-like tumors, tumor associated macrophages, regulatory T cells, detection mode and prognosis.
Audun Klingen T, Chen Y, Aas H, Akslen LA. | 09/3/2024 |
| DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms. | DDR2 signaling and mechanosensing orchestrate neuroblastoma cell fate through different transcriptome mechanisms.
Vessella T, Xiang S, Xiao C, Stilwell M, Fok J, Shohet J, Rozen E, Zhou HS, Wen Q., Free PMC Article | 05/30/2024 |
| METTL3/YTHDF1 m[6]A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer. | METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer.
Zhi D, Zhou K, Liu S, Yu W, Dong M, Yan C. | 01/29/2024 |
| DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. | DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.
Akinjiyan FA, Ibitoye Z, Zhao P, Shriver LP, Patti GJ, Longmore GD, Fuh KC., Free PMC Article | 01/27/2024 |
| DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1. | DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1.
Mitchell AV, Wu J, Meng F, Dong L, Block CJ, Song WM, Zhang B, Li J, Wu G., Free PMC Article | 08/1/2023 |
| Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study. | Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study.
Torga T, Suutre S, Kisand K, Aunapuu M, Arend A. | 02/27/2023 |
| Special issue "The advance of solid tumor research in China": Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling. | Special issue "The advance of solid tumor research in China": Discoidin domain receptor 2 promotes colorectal cancer metastasis by regulating epithelial mesenchymal transition via activating AKT signaling.
Xu X, Duan X, Wang S, Zhang Y, Gao Y, Xu X, Yeerkenbieke G, Zhou J, Li J. | 11/26/2022 |
| Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis. | Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.
Wu C, Ying J, Dai M, Peng J, Zhang D. | 10/29/2022 |
| Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer. | Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer.
Romayor I, García-Vaquero ML, Márquez J, Arteta B, Barceló R, Benedicto A., Free PMC Article | 06/25/2022 |
| Amplification of DDR2 mediates sorafenib resistance through NF-kappaB/c-Rel signaling in hepatocellular carcinoma. | Amplification of DDR2 mediates sorafenib resistance through NF-κB/c-Rel signaling in hepatocellular carcinoma.
Liu QQ, Liu YW, Xie YK, Zhang JH, Song CX, Wang JZ, Xie BH. | 01/15/2022 |
| Complex roles of discoidin domain receptor tyrosine kinases in cancer. | Complex roles of discoidin domain receptor tyrosine kinases in cancer.
Mehta V, Chander H, Munshi A. | 12/4/2021 |
| Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis. | Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis.
Barcus CE, Hwang PY, Morikis V, Brenot A, Pence P, Clarke M, Longmore GD., Free PMC Article | 10/30/2021 |
| DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. | DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway.
Lin CC, Yang WH, Lin YT, Tang X, Chen PH, Ding CC, Qu DC, Alvarez JV, Chi JT., Free PMC Article | 10/16/2021 |
| Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness. | Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness.
Jeong BY, Cho KH, Yoon SH, Park CG, Park HW, Lee HY., Free PMC Article | 06/19/2021 |
| Active MT1-MMP is tethered to collagen fibers in DDR2-containing remnants. | Active MT1-MMP is tethered to collagen fibers in DDR2-containing remnants.
Feng Y, Cai H, Huang X, Li Z, Chi Z, Ge RL. | 05/29/2021 |
| Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts. | Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts.
Wasinski B, Sohail A, Bonfil RD, Kim S, Saliganan A, Polin L, Bouhamdan M, Kim HC, Prunotto M, Fridman R., Free PMC Article | 04/3/2021 |
| Heat shock protein 47 (HSP47) binds to discoidin domain-containing receptor 2 (DDR2) and regulates its protein stability | Heat shock protein 47 (HSP47) binds to discoidin domain-containing receptor 2 (DDR2) and regulates its protein stability.
Chen J, Wang S, Zhang Z, Richards CI, Xu R., Free PMC Article | 06/13/2020 |
| Single nucleotide polymorphism in DDR2 gene is associated with smoking in european americans. | An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations.
Jiang K, Yang Z, Cui W, Su K, Ma JZ, Payne TJ, Li MD., Free PMC Article | 04/4/2020 |
| These results show a deleterious effect of high co-expression of DDR1 and DDR2 and a physical interaction between the two receptors. | DDR1 and DDR2 physical interaction leads to signaling interconnection but with possible distinct functions.
Croissant C, Tuariihionoa A, Bacou M, Souleyreau W, Sala M, Henriet E, Bikfalvi A, Saltel F, Auguste P., Free PMC Article | 06/22/2019 |
| The protein kinase inhibitor dasatinib prevented DDR2 autophosphorylation in fibroblasts. | Recurrent, Activating Variants in the Receptor Tyrosine Kinase DDR2 Cause Warburg-Cinotti Syndrome.
Xu L, Jensen H, Johnston JJ, Di Maria E, Kloth K, Cristea I, Sapp JC, Darling TN, Huryn LA, Tranebjærg L, Cinotti E, Kubisch C, Rødahl E, Bruland O, Biesecker LG, Houge G, Bredrup C., Free PMC Article | 05/18/2019 |
| DDR2 mutations were observed in 4% of cases of lung squamous cell carcinoma of European descent; no clinical characteristics were significantly associated with DDR2 mutation | Mutational Landscape of DDR2 Gene in Lung Squamous Cell Carcinoma Using Next-generation Sequencing.
Ricordel C, Lespagnol A, Llamas-Gutierrez F, de Tayrac M, Kerjouan M, Fievet A, Hamdi-Rozé H, Aliouat A, Desrues B, Mosser J, Léna H. | 04/13/2019 |
| The Epithelial-to-Mesenchymal Transition inducing factor TWIST1 drives expression of discoidin domain receptor 2 (DDR2). The collagen receptor DDR2 is critical for multiple steps of ovarian cancer progression to metastasis. | TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.
Grither WR, Divine LM, Meller EH, Wilke DJ, Desai RA, Loza AJ, Zhao P, Lohrey A, Longmore GD, Fuh KC., Free PMC Article | 03/30/2019 |
| DDR2 expression is upregulated by matrix stiffening. DDR2 controls the epithelial-mesenchymal-transition markers via c-Myb acetylation upon matrix stiffening. | DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening.
Kim D, You E, Jeong J, Ko P, Kim JW, Rhee S., Free PMC Article | 03/9/2019 |
| Higher DDR2 expression was associated with lower miR-182 levels. | Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer.
Ramalho S, Andrade LAA, Filho CC, Natal RA, Pavanello M, Ferracini AC, Sallum LF, Sarian LO, Derchain S. | 03/2/2019 |
| High DDR2 expression is associated with Gallbladder Squamous Cell/Adenosquamous Carcinomas | DDR2 and IFITM1 Are Prognostic Markers in Gallbladder Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas.
Li D, Yang Z, Liu Z, Zou Q, Yuan Y. | 02/16/2019 |