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    NTRK2 neurotrophic receptor tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 4915, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.

    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene.
    Gupta R, Dittmeier M, Wohlleben G, Nickl V, Bischler T, Luzak V, Wegat V, Doll D, Sodmann A, Bady E, Langlhofer G, Wachter B, Havlicek S, Gupta J, Horn E, Lüningschrör P, Villmann C, Polat B, Wischhusen J, Monoranu CM, Kuper J, Blum R., Free PMC Article

    09/24/2024
    Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.

    Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.
    Zhang X, Zhang Y, Yan H, Yu H, Zhang D, Mattay VS, Tan HY, Yue W., Free PMC Article

    04/5/2024
    Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.

    Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
    Ikhlef L, Yassine M, Chandouri B, Rivière L, Naves T, Dmytruk N, Gachard N, Jauberteau MO, Gallet PF., Free PMC Article

    03/15/2024
    TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.

    TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.
    Wang Y, Liang J, Xu B, Yang J, Wu Z, Cheng L.

    01/3/2024
    Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder.

    Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder.
    Paolini M, Fortaner-Uyà L, Lorenzi C, Spadini S, Maccario M, Zanardi R, Colombo C, Poletti S, Benedetti F., Free PMC Article

    11/28/2023
    miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.

    miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia.
    Li H, Hou J, Fu Y, Zhao Y, Liu J, Guo D, Lei R, Wu Y, Tang L, Fan S.

    11/14/2023
    DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.

    DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons.
    Andreska T, Lüningschrör P, Wolf D, McFleder RL, Ayon-Olivas M, Rattka M, Drechsler C, Perschin V, Blum R, Aufmkolk S, Granado N, Moratalla R, Sauer M, Monoranu C, Volkmann J, Ip CW, Stigloher C, Sendtner M.

    10/11/2023
    TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma.

    TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma.
    Kim MS, Lee WS, Jin W., Free PMC Article

    09/29/2023
    BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.

    BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells.
    Kim JH, Irfan M, Hossain MA, George A, Chung S., Free PMC Article

    08/2/2023
    Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.

    Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
    Mansour B, Vanecek T, Kastnerova L, Nosek D, Kazakov DV, Donati M.

    04/20/2023
    nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity.

    nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity.
    Biojone C, C Casarotto P, Cannarozzo C, Fred SM, Herrera-Rodríguez R, Lesnikova A, Voipio M, Castrén E.

    03/1/2023
    TRKB acts as a prognostic predictive marker in Her-2 positive breast cancer.

    TRKB acts as a prognostic predictive marker in Her-2 positive breast cancer.
    Zhang R, Zhao J, Zhao L.

    10/22/2022
    The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

    The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
    Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y., Free PMC Article

    09/24/2022
    Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors.

    Tropomyosin-related Kinase B Is Potentially a Biomarker of Prognosis and Therapeutic Target for Malignant Thymic Epithelial Tumors.
    Ozono K, Onishi H, Iwamoto N, Nakamura K, Miyoshi K, Nakamura M, Oda Y.

    08/6/2022
    The Rab11-regulated endocytic pathway and BDNF/TrkB signaling: Roles in plasticity changes and neurodegenerative diseases.

    The Rab11-regulated endocytic pathway and BDNF/TrkB signaling: Roles in plasticity changes and neurodegenerative diseases.
    Moya-Alvarado G, Guerra MV, Tiburcio R, Bravo E, Bronfman FC.

    07/30/2022
    Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.

    Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
    Ateaque S, Merkouris S, Wyatt S, Allen ND, Xie J, DiStefano PS, Lindsay RM, Barde YA., Free PMC Article

    06/25/2022
    Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies.

    Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies.
    Long A, Crouse A, Kesterson RA, Might M, Wallis D.

    05/14/2022
    Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway.

    Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway.
    Zhou X, Jian W, Luo Q, Zheng W, Deng X, Wang X, Borkhuu O, Ji C, Li D, Fang L., Free PMC Article

    05/7/2022
    BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea.

    BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea.
    Wang S, Duan H, Li B, Hong W, Li X, Wang Y, Guo ZC., Free PMC Article

    04/16/2022
    Race-Dependent Association of Single-Nucleotide Polymorphisms in TrkB Receptor in People Living with HIV and Depression.

    Race-Dependent Association of Single-Nucleotide Polymorphisms in TrkB Receptor in People Living with HIV and Depression.
    Avdoshina V, Yumoto F, Mocchetti I, Letendre SL, Tractenberg RE., Free PMC Article

    04/2/2022
    Aurora kinase A induces migration and invasion by inducing epithelial-to-mesenchymal transition in colon cancer cells.

    Aurora kinase A induces migration and invasion by inducing epithelial-to-mesenchymal transition in colon cancer cells.
    Hong OY, Kang SY, Noh EM, Yu HN, Jang HY, Kim SH, Hong J, Chung EY, Kim JS., Free PMC Article

    03/19/2022
    Treatment response to low-dose ketamine infusion for treatment-resistant depression: A gene-based genome-wide association study.

    Treatment response to low-dose ketamine infusion for treatment-resistant depression: A gene-based genome-wide association study.
    Chen MH, Kao CF, Tsai SJ, Li CT, Lin WC, Hong CJ, Bai YM, Tu PC, Su TP.

    02/26/2022
    CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles.

    CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles.
    Aitamer M, Akil H, Vignoles C, Branchaud M, Abraham J, Gachard N, Feuillard J, Jauberteau MO, Shirvani H, Troutaud D, Bentayeb H., Free PMC Article

    01/15/2022
    Inhibiting NTRK2 signaling causes endometriotic lesion regression.

    Inhibiting NTRK2 signaling causes endometriotic lesion regression.
    Lee HC, Lin SC, Wu MH, Tsai SJ.

    01/1/2022
    The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling.

    The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling.
    Kasemeier-Kulesa JC, Spengler JA, Muolo CE, Morrison JA, Woolley TE, Schnell S, Kulesa PM.

    12/25/2021
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