| Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro. | Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro.
Guo Y, Chen P, Li T, Jia L, Zhou Y, Huang J, Liang X, Zhou C, Fang C., Free PMC Article | 01/29/2022 |
| NTF4 stimulates the progression of gastric cancer via regulating FOXL1. | NTF4 stimulates the progression of gastric cancer via regulating FOXL1.
Jin J, Wang L, Liu X, Long Z, Zhou Y, Huang H, Wang Y. | 12/18/2021 |
| The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review. | The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.
Ribeiro D, Petrigna L, Pereira FC, Muscella A, Bianco A, Tavares P., Free PMC Article | 09/18/2021 |
| NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats. | NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.
Wang T, Zhang J, Li P, Ding Y, Tang J, Chen G, Zhang JH., Free PMC Article | 04/3/2021 |
| Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy. | Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy.
Yang Z, Chen Y, Wei X, Wu D, Min Z, Quan Y., Free PMC Article | 01/23/2021 |
| Meta-analysis found the levels of both NT-3 and NT-4/5 were significantly increased in bipolar disorder patients. Through subgroup analysis, this increase persisted only in patients in depressed state, but not in manic or euthymic state. In addition, we found the differences in NT-3 and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion. | State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis.
Tseng PT, Chen YW, Tu KY, Wang HY, Chung W, Wu CK, Hsu SP, Kuo HC, Lin PY. | 09/2/2017 |
| Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations. | Association between neurotrophin 4 and long-chain polyunsaturated fatty acid levels in mid-trimester amniotic fluid.
Benn K, Passos M, Jayaram A, Harris M, Bongiovanni AM, Skupski D, Witkin SS. | 06/27/2015 |
| No differences in plasma BDNF, NGF, NT3, NT4 and GDNF were found between autism spectrum disorders and control. | Circulating levels of neurotrophic factors in autism spectrum disorders.
Rodrigues DH, Rocha NP, Sousa LF, Barbosa IG, Kummer A, Teixeira AL. | 03/21/2015 |
| Patients with mastocytosis featured elevated serum levels of NGF, NT-3, and NT-4. TrkA, TrkB, and TrkC expression was also elevated. | Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis.
Peng WM, Maintz L, Allam JP, Raap U, Gütgemann I, Kirfel J, Wardelmann E, Perner S, Zhao W, Fimmers R, Walgenbach K, Oldenburg J, Schwartz LB, Novak N. | 11/2/2013 |
| The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients. | Evaluation of NTF4 as a causative gene for primary open-angle glaucoma.
Chen LJ, Ng TK, Fan AH, Leung DY, Zhang M, Wang N, Zheng Y, Liang XY, Chiang SW, Tam PO, Pang CP., Free PMC Article | 11/17/2012 |
| Studies indicate neurotrophin family comprises nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 , and Zn(2+) and Cu(2+) interactions with them and modulate their activities through conformational changes. | The inorganic perspectives of neurotrophins and Alzheimer's disease.
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E. | 10/27/2012 |
| NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis. | Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients.
Kalinowska-Łyszczarz A, Pawlak MA, Michalak S, Paprzycki W, Losy J. | 02/4/2012 |
| Suggest that a dysregulated TrkB/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts. | Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.
Avcuoglu S, Wygrecka M, Marsh LM, Günther A, Seeger W, Weissmann N, Fink L, Morty RE, Kwapiszewska G. | 11/19/2011 |
| neurotrophin 4 contributes to breast cancer cell survival and can serve as prospective target to inhibit tumor growth | Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival.
Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, Nurcombe V, Le Bourhis X, Hondermarck H. | 07/23/2011 |
| In vitro follicular assembly is significantly increased in fetal ovaries cultured with NT-4. | Neurotrophin 4 enhances in vitro follicular assembly in human fetal ovaries.
Farhi J, Fisch B, Garor R, Peled Y, Pinkas H, Abir R. | 05/14/2011 |
| Identification of a single mutation in our study suggests that NTF4 mutations are a rare cause of primary open-angle glaucoma (0.6%, 95%CI 0.02%-3.16%) in Chinese people. | Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population.
Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T, Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T., Free PMC Articles: PMC2927376, PMC2927376 | 11/13/2010 |
| present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. | Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population.
Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S, Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S. | 10/23/2010 |
| Expression of human NTF4 was unchanged during gestation in the developping ovary. | Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development.
Childs AJ, Bayne RA, Murray AA, Martins Da Silva SJ, Collins CS, Spears N, Anderson RA., Free PMC Article | 08/23/2010 |
| No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. | No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.
Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA, Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA., Free PMC Articles: PMC2833375, PMC2833375 | 04/19/2010 |
| NTF4 mutations impair neurotrophin-4 signaling in patients with primary open-angle glaucoma and lead to decreased activation of TrkB | Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma.
Pasutto F, Matsumoto T, Mardin CY, Sticht H, Brandstätter JH, Michels-Rautenstrauss K, Weisschuh N, Gramer E, Ramdas WD, van Koolwijk LM, Klaver CC, Vingerling JR, Weber BH, Kruse FE, Rautenstrauss B, Barde YA, Reis A., Free PMC Article | 01/21/2010 |
| Data show that the levels of NT-4/5 levels are significantly higher in bipolar disorder patients than in controlsNT-4/5. immunocontent alterations in bipolar disorder. | Increased serum neurotrophin-4/5 levels in bipolar disorder.
Walz JC, Magalhães PV, Giglio LM, Cunha AB, Stertz L, Fries GR, Andreazza AC, Kapczinski F. | 01/21/2010 |
| Neurotrophin 4/5 plays a role in the proliferation and differentiation of periodontal ligament cells. | Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells.
Mizuno N, Shiba H, Inui T, Takeda K, Kajiya M, Hasegawa N, Kawaguchi H, Kurihara H. | 01/21/2010 |
| NT-3, NT-4, and nerve growth factor (NGF) induce cell migration in melanoma, with a stronger effect on metastatic cell lines. | Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.
Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (8) articlesIdentification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population.
Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T, Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T. Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population.
Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S, Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.
Gratacòs M, Escaramís G, Bustamante M, Saus E, Agüera Z, Bayés M, Cellini E, de Cid R, Fernández-Aranda F, Forcano L, González JR, Gorwood P, Hebebrand J, Hinney A, Mercader JM, Nacmias B, Ramoz N, Ribasés M, Ricca V, Romo L, Sorbi S, Versini A, Estivill X. No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.
Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA, Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.
Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, Banerjee-Basu S, Baron-Cohen S. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders.
Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, Cellini E, de Cid R, Dierssen M, Escaramís G, Fernández-Aranda F, Forcano L, Gallego X, González JR, Gorwood P, Hebebrand J, Hinney A, Nacmias B, Puig A, Ribasés M, Ricca V, Romo L, Sorbi S, Versini A, Gratacòs M, Estivill X. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder.
Ribasés M, Hervás A, Ramos-Quiroga JA, Bosch R, Bielsa A, Gastaminza X, Fernández-Anguiano M, Nogueira M, Gómez-Barros N, Valero S, Gratacòs M, Estivill X, Casas M, Cormand B, Bayés M. | 03/13/2008 |
| Re-expression of the p75NTR appears to partially reverse de-differentiation of prostate cancer cells by up-regulating the expression of CRABPI for localized sequestration of retinoids. | A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression.
Nalbandian A, Pang AL, Rennert OM, Chan WY, Ravindranath N, Djakiew D. | 01/21/2010 |