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    ATP2B1 ATPase plasma membrane Ca2+ transporting 1 [ Homo sapiens (human) ]

    Gene ID: 490, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.

    ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.
    Kobayashi Y, Yatsu K, Haruna A, Kawano R, Ozawa M, Haze T, Komiya S, Suzuki S, Ohki Y, Fujiwara A, Saka S, Hirawa N, Toya Y, Tamura K., Free PMC Article

    04/24/2024
    Association between polymorphism and haplotype of ATP2B1 gene and skeletal fluorosis in Han population.

    Association between polymorphism and haplotype of ATP2B1 gene and skeletal fluorosis in Han population.
    Gao Y, Liu Y, Jiang Y, Qin M, Guan Z, Gao Y, Yang Y.

    03/1/2024
    The Plasma Membrane Ca[2+]-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.

    The Plasma Membrane Ca(2+)-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.
    Berrocal M, Mata AM.

    05/4/2023
    ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.

    ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
    Yang X, Lu L, Wu C, Zhang F.

    03/19/2023
    Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.

    Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.
    Khoshbakht S, Mokhtari M, Moravveji SS, Azimzadeh Jamalkandi S, Masoudi-Nejad A., Free PMC Article

    05/14/2022
    De novo variants in ATP2B1 lead to neurodevelopmental delay.

    De novo variants in ATP2B1 lead to neurodevelopmental delay.
    Rahimi MJ, Urban N, Wegler M, Sticht H, Schaefer M, Popp B, Gaunitz F, Morleo M, Nigro V, Maitz S, Mancini GMS, Ruivenkamp C, Suk EK, Bartolomaeus T, Merkenschlager A, Koboldt D, Bartholomew D, Stegmann APA, Sinnema M, Duynisveld I, Salvarinova R, Race S, de Vries BBA, Trimouille A, Naudion S, Marom D, Hamiel U, Henig N, Demurger F, Rahner N, Bartels E, Hamm JA, Putnam AM, Person R, Abou Jamra R, Oppermann H., Free PMC Article

    05/14/2022
    ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia.

    ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia.
    Zhou ZY, Wang XJ, Chen GZ.

    04/30/2022
    ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population.

    ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population.
    Althwab SA, Ahmed AA, Rasheed Z, Alkhowailed M, Hershan A, Alsagaby S, Alblihed MA, Alaqeel A, Alrehaili J, Alhumaydhi FA, Alkhamiss A, Abdulmonem WA.

    03/19/2022
    Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.

    Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.
    Njegic A, Swiderska A, Marris C, Armesilla AL, Cartwright EJ., Free PMC Article

    01/15/2022
    Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.

    Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
    Berrocal M, Saez L, Mata AM., Free PMC Article

    07/17/2021
    Serum from patients with hypertension promotes endothelial dysfunction to induce trophoblast invasion through the miR27b3p/ATPase plasma membrane Ca(2+) transporting 1 axis.

    Serum from patients with hypertension promotes endothelial dysfunction to induce trophoblast invasion through the miR‑27b‑3p/ATPase plasma membrane Ca(2+) transporting 1 axis.
    Zhu L, Liu Z., Free PMC Article

    05/15/2021
    Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases.

    Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases.
    Boczek T, Sobolczyk M, Mackiewicz J, Lisek M, Ferenc B, Guo F, Zylinska L., Free PMC Article

    05/8/2021
    Association of ATP2B1 gene polymorphism with incidence of eclampsia.

    Association of ATP2B1 gene polymorphism with incidence of eclampsia.
    Sun XM, Yang M, Jiang CX.

    02/13/2021
    ATP2B1 rs17249754 is positively associated with the risk of developing essential hypertension in patients from Burkina Faso, West Africa.

    Positive association between ATP2B1 rs17249754 and essential hypertension: a case-control study in Burkina Faso, West Africa.
    Sombié HK, Kologo JK, Tchelougou D, Ouédraogo SY, Ouattara AK, Compaoré TR, Nagalo BM, Sorgho AP, Nagabila I, Soubeïga ST, Djigma FW, Yonli AT, Zabsonré P, Millogo H, Simporé J., Free PMC Article

    03/21/2020
    No significant association was found between ATP2B1 gene polymorphism and the odds of high blood pressure.

    Association between ATP2B1 and CACNB2 polymorphisms and high blood pressure in a population of Lithuanian children and adolescents: a cross-sectional study.
    Simonyte S, Kuciene R, Dulskiene V, Lesauskaite V., Free PMC Article

    10/26/2019
    enhanced eNOS activity induced by ATP2B1 gene silencing may be mediated via higher levels of intracellular Ca(2+), and the effect was confirmed to be dependent on the eNOS-calmodulin interaction

    ATP2B1 Gene Silencing Increases NO Production Under Basal Conditions Through the Ca(2+)/calmodulin/eNOS Signaling Pathway in Endothelial Cells.
    Long Y, Chen SW, Gao CL, He XM, Liang GN, Wu J, Jiang CX, Liu X, Wang F, Chen F.

    06/8/2019
    rs17249754-A (OR = 0.43, p = 0.0002) and rs1401982-G (OR = 0.47, p = 0.0007) were associated with decreased susceptibility of concurrent extra and intracranial stenosis even after Bonferroni correction. These two minor alleles were also significantly associated with less stenotic arteries and moderate-to-severe stenosis.

    Association of ATP2B1 common variants with asymptomatic intracranial and extracranial large artery stenosis in hypertension patients.
    An D, Zhang J, Tang X, Gao P, Li Y, Wang Y, Zhu D.

    05/25/2019
    Cryoelectron microscopy reveals the PMCA1 structure in complex with neuroplastin.

    Structure of the human plasma membrane Ca(2+)-ATPase 1 in complex with its obligatory subunit neuroplastin.
    Gong D, Chi X, Ren K, Huang G, Zhou G, Yan N, Lei J, Zhou Q., Free PMC Article

    12/29/2018
    people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K

    People with the major alleles of ATP2B1 rs17249754 increases the risk of hypertension in high ratio of sodium and potassium, and low calcium intakes.
    Daily JW, Kim BC, Liu M, Park S.

    07/14/2018
    Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect

    Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population.
    Xu J, Qian HX, Hu SP, Liu LY, Zhou M, Feng M, Su J, Ji LD., Free PMC Article

    12/17/2016
    Excessive sodium intake significantly modified the risk of developing Hypertension associated with ATP2B1 rs17249754 genetic trait. Homozygote carriers may be at higher risk of hypertension, when they consume excessive sodium intake.

    Interaction according to urinary sodium excretion level on the association between ATP2B1 rs17249754 and incident hypertension: the Korean genome epidemiology study.
    Lee S, Kim SH, Shin C.

    12/17/2016
    Data show that plasma membrane Ca(2+)-ATPase (PMCA) was associated with tubulin in normotensive and hypertensive erythrocytes.

    PMCA activity and membrane tubulin affect deformability of erythrocytes from normal and hypertensive human subjects.
    Monesterolo NE, Nigra AD, Campetelli AN, Santander VS, Rivelli JF, Arce CA, Casale CH.

    05/21/2016
    rs11105378 near ATP2B1 was associated with increased systolic and diastolic blood pressure in a Chinese population.

    Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index.
    Li J, Shi J, Huang W, Sun J, Wu Y, Duan Q, Luo J, Lange LA, Gordon-Larsen P, Zheng SL, Yuan W, Wang Y, Popkin BM, Mo Z, Xu J, Du S, Mohlke KL, Lange EM., Free PMC Article

    04/9/2016
    ATP2B1 rs12817819 A allele is associated with increased risk for drug resistant hypertension.

    Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension.
    Fontana V, McDonough CW, Gong Y, El Rouby NM, Sá AC, Taylor KD, Chen YD, Gums JG, Chapman AB, Turner ST, Pepine CJ, Johnson JA, Cooper-DeHoff RM., Free PMC Article

    10/17/2015
    While PMCA1b has a housekeeping function in colon cancer cells, PMCA4b participates in the reorganization of the calcium signaling machinery during cell differentiation.

    Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells.
    Ribiczey P, Papp B, Homolya L, Enyedi Á, Kovács T.

    10/3/2015
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