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    NPM1 nucleophosmin 1 [ Homo sapiens (human) ]

    Gene ID: 4869, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation.

    Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation.
    Lakshmi Ch NP, Sivagnanam A, Raja S, Mahalingam S., Free PMC Article

    08/26/2024
    Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations.

    Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations.
    Selheim F, Aasebø E, Reikvam H, Bruserud Ø, Hernandez-Valladares M., Free PMC Article

    08/9/2024
    Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.

    Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.
    Zhang S, Zhang Y, Duan X, Wang B, Zhan Z., Free PMC Article

    07/2/2024
    MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion.

    MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion.
    Fang Y, Zhang J, Zhu D, Mei Q, Liao T, Cheng H, He Y, Cao Y, Wei Z., Free PMC Article

    06/26/2024
    Phosphorylation Code of Human Nucleophosmin Includes Four Cryptic Sites for Hierarchical Binding of 14-3-3 Proteins.

    Phosphorylation Code of Human Nucleophosmin Includes Four Cryptic Sites for Hierarchical Binding of 14-3-3 Proteins.
    Kapitonova AA, Perfilova KV, Cooley RB, Sluchanko NN.

    06/20/2024
    Comprehensive Molecular Profiling of NPM1-Mutated Acute Myeloid Leukemia Using RNAseq Approach.

    Comprehensive Molecular Profiling of NPM1-Mutated Acute Myeloid Leukemia Using RNAseq Approach.
    Petiti J, Pignochino Y, Schiavon A, Giugliano E, Berrino E, Giordano G, Itri F, Dragani M, Cilloni D, Lo Iacono M., Free PMC Article

    04/17/2024
    ZNF692 regulates nucleolar morphology by interacting with NPM1 and modifying its self-assembly properties.

    ZNF692 regulates nucleolar morphology by interacting with NPM1 and modifying its self-assembly properties.
    Brown IN, Levario A, Jiang C, Stachera W, Rodriguez E, Hao YH, Woodruff JB, Lafita-Navarro MC, Conacci-Sorrell M., Free PMC Article

    04/4/2024
    Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML.

    Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML.
    Chan O, Al Ali N, Tashkandi H, Ellis A, Ball S, Grenet J, Hana C, Deutsch Y, Zhang L, Hussaini M, Song J, Yun S, Talati C, Kuykendall A, Padron E, Walker A, Roboz G, Desai P, Sallman D, Sweet K, Komrokji R, Lancet J., Free PMC Article

    02/29/2024
    NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions.

    NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions.
    Patel SS., Free PMC Article

    02/21/2024
    AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.

    AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.
    Chen H, Hu J, Xiong X, Chen H, Lin B, Chen Y, Li Y, Cheng D, Li Z., Free PMC Article

    02/7/2024
    The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.

    The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
    Korai A, Lin X, Tago K, Funakoshi-Tago M.

    01/16/2024
    Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.

    Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.
    Wang H, Zhou Z, Zhang J, Hao T, Wang P, Wu P, Su R, Yang H, Deng G, Chen S, Gu L, He Y, Zeng L, Zhang C, Yin S.

    12/21/2023
    Clinical features and prognostic significance of DNMT3A, FLT3, and NPM1 mutations in de novo acute myeloid leukemia patients.

    Clinical features and prognostic significance of DNMT3A, FLT3, and NPM1 mutations in de novo acute myeloid leukemia patients.
    Chen M, Zeng Z, Li X, Qin W, Cai X, Chen S, Lu X.

    11/20/2023
    The acidic stretch and the C-terminal nuclear export signal motif of NPM1 mutant: are they druggable in AML?

    The acidic stretch and the C-terminal nuclear export signal motif of NPM1 mutant: are they druggable in AML?
    Falini B, Gjertsen BT, Andresen V.

    11/8/2023
    The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.

    The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.
    Hassan M M, ElTahlawi S, Shaker OG, Magdy M.

    11/8/2023
    Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

    Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
    Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T., Free PMC Article

    10/8/2023
    DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations.

    DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations.
    Zhang H, Chen Q, Zhang Q, Gan H, Li H, Chen S, Shan H, Pang P, He H., Free PMC Article

    09/19/2023
    FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.

    FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.
    Han D, Guan L, Zhang Y, Yang H, Si L, Jia T, Wu Y, Lv K, Song T, Yang G.

    09/18/2023
    Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma.

    Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma.
    Fu D, Yan J, Zhang Z, Liu Y, Ma X, Ding J, Yang S, Zhao R, Chang A, Gao C, Liu J, Zhao T, Wang X, Huang C, Gao S, Ma Y, Tang B, Feng Y, Wang H, Hao J., Free PMC Article

    09/8/2023
    KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1.

    KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1.
    Cheng X, Shen C, Liao Z.

    08/30/2023
    Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis.

    Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis.
    Liang F, Luo Q, Han H, Zhang J, Yang Y, Chen J., Free PMC Article

    05/13/2023
    Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML.

    Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML.
    Issa GC, Bidikian A, Venugopal S, Konopleva M, DiNardo CD, Kadia TM, Borthakur G, Jabbour E, Pemmaraju N, Yilmaz M, Short NJ, Maiti A, Sasaki K, Masarova L, Pierce S, Takahashi K, Tang G, Loghavi S, Patel K, Andreeff M, Bhalla K, Garcia-Manero G, Ravandi F, Kantarjian H, Daver N., Free PMC Article

    03/24/2023
    Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs.

    Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs.
    Donato E, Correia N, Andresen C, Karpova D, Würth R, Klein C, Sohn M, Przybylla A, Zeisberger P, Rothfelder K, Salih H, Bonig H, Stasik S, Röllig C, Dolnik A, Bullinger L, Buchholz F, Thiede C, Hübschmann D, Trumpp A., Free PMC Article

    03/24/2023
    Mutant NPM1: Nuclear export and the mechanism of leukemogenesis.

    Mutant NPM1: Nuclear export and the mechanism of leukemogenesis.
    Falini B, Martelli MP, Brunetti L.

    03/21/2023
    DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant.

    DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant.
    Dillon LW, Gui G, Page KM, Ravindra N, Wong ZC, Andrew G, Mukherjee D, Zeger SL, El Chaer F, Spellman S, Howard A, Chen K, Auletta J, Devine SM, Jimenez Jimenez AM, De Lima MJG, Litzow MR, Kebriaei P, Saber W, Weisdorf DJ, Hourigan CS., Free PMC Article

    03/11/2023
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