| High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study. | High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study.
Cao XM, Kang WD, Xia TH, Yuan SB, Guo CA, Wang WJ, Liu HB., Free PMC Article | 07/10/2023 |
| Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma. | Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma.
Huang Y, Xiao L, Daba MY, Xu D, Wang Y, Li L, Li Q, Liu B, Qin W, Zhang H, Yuan X., Free PMC Article | 05/10/2023 |
| NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling. | NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
Ma S, Chen Y, Quan P, Zhang J, Han S, Wang G, Qi R, Zhang X, Wang F, Yuan J, Yang X, Jia W, Qin W., Free PMC Article | 04/1/2023 |
| Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis. | Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis.
Yao R, Zhou L, Guo Z, Zhang D, Zhang T., Free PMC Article | 03/19/2022 |
| Roles of NPAS2 in circadian rhythm and disease. | Roles of NPAS2 in circadian rhythm and disease.
Peng LU, Bai G, Pang Y. | 02/12/2022 |
| Genetic variants in NPAS2 gene and clinical outcomes of resectable non-small-cell lung cancer. | Genetic variants in NPAS2 gene and clinical outcomes of resectable non-small-cell lung cancer.
He Y, Wang G, Wang Q, Zhao Z, Gan L, Yang S, Wang Y, Guo S, An J, Zhang J, Zhang Z, Zhou F. | 10/2/2021 |
| Circadian genes polymorphisms, night work and prostate cancer risk: Findings from the EPICAP study. | Circadian genes polymorphisms, night work and prostate cancer risk: Findings from the EPICAP study.
Wendeu-Foyet MG, Cénée S, Koudou Y, Trétarre B, Rébillard X, Cancel-Tassin G, Cussenot O, Boland A, Olaso R, Deleuze JF, Blanché H, Lamy PJ, Mulot C, Laurent-Puig P, Truong T, Menegaux F. | 04/17/2021 |
| Our findings demonstrate that NPAS2 plays a critical role in glucose metabolism reprogramming, suggesting that NPAS2 may serve as a potential therapeutic target in HCC. | Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells.
Yuan P, Yang T, Mu J, Zhao J, Yang Y, Yan Z, Hou Y, Chen C, Xing J, Zhang H, Li J. | 06/20/2020 |
| Study reported an association between the risk of prostate cancer and the circadian pathway where significant associations were found for the genes NPAS2 and PER1. | Circadian genes and risk of prostate cancer: Findings from the EPICAP study.
Wendeu-Foyet MG, Koudou Y, Cénée S, Trétarre B, Rébillard X, Cancel-Tassin G, Cussenot O, Boland A, Bacq D, Deleuze JF, Lamy PJ, Mulot C, Laurent-Puig P, Truong T, Menegaux F. | 01/18/2020 |
| NPAS2 hypomethylation occurs at the early stage of PD and is a moderate biomarker for distinguishing PD patients from healthy subjects. | Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson's disease patients.
Mao W, Zhao C, Ding H, Liang K, Xue J, Chan P, Cai Y. | 11/10/2018 |
| NPAS2 has a critical role in HCC cell survival and tumor growth, which is mainly mediated by transcriptional upregulation of CDC25A. | NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A.
Yuan P, Li J, Zhou F, Huang Q, Zhang J, Guo X, Lyu Z, Zhang H, Xing J., Free PMC Article | 11/18/2017 |
| Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (ppathway < 0.00625). The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (pgene = 0.00078); the latter being significant after Bonferroni correction. | Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.
Gu F, Zhang H, Hyland PL, Berndt S, Gapstur SM, Wheeler W, Ellipse Consortium T, Amos CI, Bezieau S, Bickeböller H, Brenner H, Brennan P, Chang-Claude J, Conti DV, Doherty JA, Gruber SB, Harrison TA, Hayes RB, Hoffmeister M, Houlston RS, Hung RJ, Jenkins MA, Kraft P, Lawrenson K, McKay J, Markt S, Mucci L, Phelan CM, Qu C, Risch A, Rossing MA, Wichmann HE, Shi J, Schernhammer E, Yu K, Landi MT, Caporaso NE., Free PMC Article | 10/14/2017 |
| Significantly, this study is the first to show that a variant copy number GGC repeat sequence in the NPAS2 clock gene associates with melanoma risk and which may be useful in the assessment of melanoma predisposition. | A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma.
Franzoni A, Markova-Car E, Dević-Pavlić S, Jurišić D, Puppin C, Mio C, De Luca M, Petruz G, Damante G, Pavelić SK., Free PMC Article | 10/7/2017 |
| CLOCK, ARNTL, and NPAS2 gene polymorphisms may have a role in seasonal variations in mood and behavior | Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior.
Kim HI, Lee HJ, Cho CH, Kang SG, Yoon HK, Park YM, Lee SH, Moon JH, Song HM, Lee E, Kim L. | 04/23/2016 |
| Genetic variations in NPAS2 might be a biomarker for a seasonal pattern in bipolar disorders. | Genetic association study of circadian genes with seasonal pattern in bipolar disorders.
Geoffroy PA, Lajnef M, Bellivier F, Jamain S, Gard S, Kahn JP, Henry C, Leboyer M, Etain B., Free PMC Article | 03/26/2016 |
| With whole-exome sequencing a novel mutation in NPAS2 was identified in a Turkish family with nonobstructive azoospermia. | Whole-exome sequencing identifies novel homozygous mutation in NPAS2 in family with nonobstructive azoospermia.
Ramasamy R, Bakırcıoğlu ME, Cengiz C, Karaca E, Scovell J, Jhangiani SN, Akdemir ZC, Bainbridge M, Yu Y, Huff C, Gibbs RA, Lupski JR, Lamb DJ., Free PMC Article | 01/2/2016 |
| NPAS2 rs2305160 polymorphism does not appear to have any association with risk of chronic lymphocytic leukemia in our Pakistani population. | Lack of association of the NPAS2 gene Ala394Thr polymorphism (rs2305160:G>A) with risk of chronic lymphocytic leukemia.
Rana S, Shahid A, Ullah H, Mahmood S. | 06/6/2015 |
| distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between schizophrenic patients with and without RLS | Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia.
Jung JS, Lee HJ, Cho CH, Kang SG, Yoon HK, Park YM, Moon JH, Yang HJ, Song HM, Kim L. | 03/7/2015 |
| Two single nucleotide polymorphisms in RORA were associated with breast cancer in the whole sample and among postmenopausal women, and we also reported an association with CLOCK, RORA, and NPAS2 in the analyses at the gene level | Breast cancer risk, nightwork, and circadian clock gene polymorphisms.
Truong T, Liquet B, Menegaux F, Plancoulaine S, Laurent-Puig P, Mulot C, Cordina-Duverger E, Sanchez M, Arveux P, Kerbrat P, Richardson S, Guénel P. | 02/14/2015 |
| Functional rs1053096 and rs2305160 polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients. | Functional polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients.
Yuan P, Wang S, Zhou F, Wan S, Yang Y, Huang X, Zhang Z, Zhu Y, Zhang H, Xing J., Free PMC Article | 10/25/2014 |
| NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer. | Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer.
Xue X, Liu F, Han Y, Li P, Yuan B, Wang X, Chen Y, Kuang Y, Zhi Q, Zhao H. | 09/27/2014 |
| Variants in NPAS2 have been associated with seasonality and seasonal affective disorder, phenotypes that could reflect circadian rhythm disruption. | Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly.
Evans DS, Parimi N, Nievergelt CM, Blackwell T, Redline S, Ancoli-Israel S, Orwoll ES, Cummings SR, Stone KL, Tranah GJ, Study of Osteoporotic Fractures (SOF), Osteoporotic Fractures in Men (MrOS) Study Group., Free PMC Article | 09/7/2013 |
| Genetic variants of NPAS2 associate with seasonal affective disorder or winter depression. | Clock gene variants in mood and anxiety disorders.
Partonen T. | 03/9/2013 |
| Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS. | Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.
Smith AK, Fang H, Whistler T, Unger ER, Rajeevan MS., Free PMC Article | 01/21/2012 |
| found a novel functional SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3'UTR of NPAS2 | A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk.
Wang F, Hu Z, Yang R, Tang J, Liu Y, Hemminki K, Sutter C, Wappenschmidt B, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B, Shen H. | 11/26/2011 |