| Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma. | Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma.
Zhang Z, Tang Y, Li L, Yang W, Xu Y, Zhou J, Ma K, Zhang K, Zhuang H, Gong Y, Gong K., Free PMC Article | 11/5/2022 |
| FXYD2 is functionally upregulated in ovarian clear cell carcinoma and may serve as a promising prognostic biomarker and therapeutic target of cardiac glycosides in OCCC | Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma.
Hsu IL, Chou CY, Wu YY, Wu JE, Liang CH, Tsai YT, Ke JY, Chen YL, Hsu KF, Hong TM., Free PMC Article | 05/19/2018 |
| Recurrent FXYD2 p.Gly41Arg mutation is associated with isolated dominant hypomagnesaemia. | Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia.
de Baaij JH, Dorresteijn EM, Hennekam EA, Kamsteeg EJ, Meijer R, Dahan K, Muller M, van den Dorpel MA, Bindels RJ, Hoenderop JG, Devuyst O, Knoers NV. | 10/24/2015 |
| FXYD2b could regulate the Na,K-ATPase by modulating the effective membrane surface electrostatics near the ion binding sites of the pump. | Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.
Gong XM, Ding Y, Yu J, Yao Y, Marassi FM., Free PMC Article | 02/14/2015 |
| our findings suggested that FXYD2c played a role in regulation of NKA activity by enhancing the expression of NKA in HK-2 cells upon hypertonic challenge. | FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge.
Chang CY, Tang CH, Hsin YH, Lai HT, Lee TH. | 08/16/2014 |
| PCBD1 (dimerization cofactor of HNF-1alpha) is coactivator of the HNF1B-mediated transcription necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule. | Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting.
Ferrè S, de Baaij JH, Ferreira P, Germann R, de Klerk JB, Lavrijsen M, van Zeeland F, Venselaar H, Kluijtmans LA, Hoenderop JG, Bindels RJ., Free PMC Article | 05/10/2014 |
| This is the first report demonstrating the potential utility of FXYD2 immunohistochemistry in the diagnosis of chromophobe renal cell carcinoma | Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors.
Gaut JP, Crimmins DL, Lockwood CM, McQuillan JJ, Ladenson JH. | 12/14/2013 |
| findings confirm the presence of an FXYD2 peptide in the crab gill Na,K-ATPase and demonstrate that this peptide plays an important role in regulating enzyme activity | Identification of a crab gill FXYD2 protein and regulation of crab microsomal Na,K-ATPase activity by mammalian FXYD2 peptide.
Silva EC, Masui DC, Furriel RP, McNamara JC, Barrabin H, Scofano HM, Perales J, Teixeira-Ferreira A, Leone FA, Fontes CF. | 10/27/2012 |
| wild type HNF1B specifically induces FXYD2A transcription whereas all HNF1B mutants partially prevented it. | HNF-1B specifically regulates the transcription of the γa-subunit of the Na+/K+-ATPase.
Ferrè S, Veenstra GJ, Bouwmeester R, Hoenderop JG, Bindels RJ. | 02/26/2011 |
| Datab propose human FXYD2gammaa as a novel beta cell-specific biomarker. | A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker.
Flamez D, Roland I, Berton A, Kutlu B, Dufrane D, Beckers MC, De Waele E, Rooman I, Bouwens L, Clark A, Lonneux M, Jamar JF, Goldman S, Maréchal D, Goodman N, Gianello P, Van Huffel C, Salmon I, Eizirik DL. | 08/30/2010 |
| Study reveals, in various human tissues, the specific expression of FXYD2, which may associate with Na, K-ATPase in selected cell types and modulate its catalytic properties. | Differential cellular expression of FXYD1 (phospholemman) and FXYD2 (gamma subunit of Na, K-ATPase) in normal human tissues: a study using high density human tissue microarrays.
Floyd RV, Wray S, Martín-Vasallo P, Mobasheri A. | 05/3/2010 |
| Data conclude that human proximal tubular cells respond to a hyperosmotic challenge with an increase in FXYD2 and Na,K-ATPase protein expression, though to a smaller absolute extent in patient cells. | FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia?
Cairo ER, Swarts HG, Wilmer MJ, Willems PH, Levtchenko EN, De Pont JJ, Koenderink JB., Free PMC Article | 03/29/2010 |
| results suggest that FXYD2 can mediate basolateral extrusion of magnesium from cultured renal epithelial cells and provide new insights into the understanding of the possible physiological roles of FXYD2 wild-type and mutant proteins. | Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel.
Sha Q, Pearson W, Burcea LC, Wigfall DA, Schlesinger PH, Nichols CG, Mercer RW., Free PMC Article | 01/21/2010 |
| structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid | Structures of the FXYD regulatory proteins in lipid micelles and membranes.
Franzin CM, Gong XM, Teriete P, Marassi FM., Free PMC Article | 01/21/2010 |
| Activity of GLAST directs FXYD2 protein/gamma subunit to the cell surface, that leads to the activation of the astroglial sodium pump. | Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes.
Gegelashvili M, Rodriguez-Kern A, Sung L, Shimamoto K, Gegelashvili G. | 01/21/2010 |
| the TM domain of FYXD2 effects the shift in apparent Na+ affinity | Modulation of Na,K-ATPase by the gamma subunit: studies with transfected cells and transmembrane mimetic peptides.
Zouzoulas A, Therien AG, Scanzano R, Deber CM, Blostein R. | 01/21/2010 |
| Expression in transfectants reduces Na+ and K+ affinity of Na,K-ATPase. Endogenous expression in certain nephron segments correlates with low Na+ affinity in Na,K-ATPase. | The gamma subunit modulates Na(+) and K(+) affinity of the renal Na,K-ATPase.
Arystarkhova E, Wetzel RK, Asinovski NK, Sweadner KJ. | 10/30/2000 |