| Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition. | Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition.
Zhu R, Shirley CM, Chu SH, Li L, Nguyen BH, Seo J, Wu M, Seale T, Duffield AS, Staudt LM, Levis M, Hu Y, Small D. | 07/23/2024 |
| NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis. | NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.
López-López S, Romero de Ávila MJ, González-Gómez MJ, Nueda ML, Baladrón V, Monsalve EM, García-Ramírez JJ, Díaz-Guerra MJM. | 10/11/2023 |
| Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort. | Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort.
Budhbhatti U, Chauhan A, Bhatt D, Parmar C, Damani V, Patel A, Joshi C. | 09/26/2023 |
| NOTCH4[DeltaL12_16] sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1. | NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1.
Zhang B, Dong S, Wang J, Huang T, Zhao P, Xu J, Liu D, Fu L, Wang L, Wang G, Zou C., Free PMC Article | 06/16/2023 |
| NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population. | NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population.
Zhong M, Zhang J, Li Z, Liu Z, Fan H, Su H, Meng H, Zhang X, Li X, Duan CZ, He X. | 03/7/2023 |
| Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis. | Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis.
Fang W, Liu H, Qin L, Wang J, Huang X, Pan S, Zheng R., Free PMC Article | 03/1/2023 |
| JAG1-NOTCH4 mechanosensing drives atherosclerosis. | JAG1-NOTCH4 mechanosensing drives atherosclerosis.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJ, Serbanovic-Canic J, Evans PC., Free PMC Article | 09/24/2022 |
| NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma. | NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma.
Li H, Zhang Q, Duan Q, Tan Y, Sun T, Qi C., Free PMC Article | 09/3/2022 |
| Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer. | Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.
Liu D, Hofman P. | 06/25/2022 |
| Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene. | Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.
Zhang Y, Li S, Li X, Yang Y, Li W, Xiao X, Li M, Lv L, Luo X. | 02/26/2022 |
| NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-gamma and TLR4 Signaling. | NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling.
López-López S, Romero de Ávila MJ, Hernández de León NC, Ruiz-Marcos F, Baladrón V, Nueda ML, Laborda J, García-Ramírez JJ, Monsalve EM, Díaz-Guerra MJM., Free PMC Article | 02/12/2022 |
| Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4. | Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche S, Marenholz I, Esparza-Gordillo J, Arnau-Soler A, Pairo-Castineira E, Rüschendorf F, Ahluwalia TS, Almqvist C, Arnold A, Australian Asthma Genetics Consortium (AAGC), Baurecht H, Bisgaard H, Bønnelykke K, Brown SJ, Bustamante M, Curtin JA, Custovic A, Dharmage SC, Esplugues A, Falchi M, Fernandez-Orth D, Ferreira MAR, Franke A, Gerdes S, Gieger C, Hakonarson H, Holt PG, Homuth G, Hubner N, Hysi PG, Jarvelin MR, Karlsson R, Koppelman GH, Lau S, Lutz M, Magnusson PKE, Marks GB, Müller-Nurasyid M, Nöthen MM, Paternoster L, Pennell CE, Peters A, Rawlik K, Robertson CF, Rodriguez E, Sebert S, Simpson A, Sleiman PMA, Standl M, Stölzl D, Strauch K, Szwajda A, Tenesa A, Thompson PJ, Ullemar V, Visconti A, Vonk JM, Wang CA, Weidinger S, Wielscher M, Worth CL, Xu CJ, Lee YA., Free PMC Article | 12/18/2021 |
| Unsuspected Associations of Variants within the Genes NOTCH4 and STEAP2-AS1 Uncovered by a GWAS in Endemic Pemphigus Foliaceus. | Unsuspected Associations of Variants within the Genes NOTCH4 and STEAP2-AS1 Uncovered by a GWAS in Endemic Pemphigus Foliaceus.
Augusto DG, de Almeida RC, Farias TDJ, Magalhães WCS, Malheiros D, Lima-Costa MF, Barreto ML, Horta BL, Kumar V, Wittig M, Franke A, Busch H, Schmidt E, Roselino AM, Tarazona-Santos E, Boldt ABW, Petzl-Erler ML. | 12/11/2021 |
| Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy. | Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy.
Long J, Wang D, Yang X, Wang A, Lin Y, Zheng M, Zhang H, Sang X, Wang H, Hu K, Zhao H., Free PMC Article | 10/23/2021 |
| Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma. | Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma.
Fukusumi T, Guo TW, Ren S, Haft S, Liu C, Sakai A, Ando M, Saito Y, Sadat S, Califano JA., Free PMC Article | 10/16/2021 |
| NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis. | NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis.
Jin K, Wen Z, Wu B, Zhang H, Qiu J, Wang Y, Warrington KJ, Berry GJ, Goronzy JJ, Weyand CM., Free PMC Article | 09/11/2021 |
| Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. | Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA., Free PMC Article | 06/26/2021 |
| Methylation status of CpG sites in the NOTCH4 promoter region regulates NOTCH4 expression in patients with tetralogy of Fallot. | Methylation status of CpG sites in the NOTCH4 promoter region regulates NOTCH4 expression in patients with tetralogy of Fallot.
Zhu Y, Ye M, Xu H, Gu R, Ma X, Chen M, Li X, Sheng W, Huang G., Free PMC Article | 05/1/2021 |
| A Notch4 missense mutation is associated with susceptibility to tuberculosis in Chinese population. | A Notch4 missense mutation is associated with susceptibility to tuberculosis in Chinese population.
Zhang J, Jiao L, Bai H, Wu Q, Wu T, Liu T, Hu X, Song J, Ying B. | 02/20/2021 |
| A common variant of the NOTCH4 gene modulates functional connectivity of the occipital cortex and its relationship with schizotypal traits. | A common variant of the NOTCH4 gene modulates functional connectivity of the occipital cortex and its relationship with schizotypal traits.
Xie X, Zu M, Zhang L, Bai T, Wei L, Huang W, Ji GJ, Qiu B, Hu P, Tian Y, Wang K., Free PMC Article | 02/13/2021 |
| Association of GWAS-supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population. | Association of GWAS-supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population.
Liang SQ, Deng JM, Wei X, Chen ZR, Yang ML, Qin HJ, Zhang JQ, He ZY., Free PMC Article | 12/19/2020 |
| that NOTCH4 expression was decreased in colorectal cancer | NOTCH4 regulates colorectal cancer proliferation, invasiveness, and determines clinical outcome of patients.
Zhang Z, Bu X, Yang J, Zhu S, He S, Zheng J, Wang W, Chu D. | 10/5/2019 |
| Results suggest NOTCH4 SNPs as possible genetic risk factors for the development and clinical presentation of brain arteriovenous malformation and a role of NOTCH4 in the pathogenesis of this disease. | NOTCH4 gene polymorphisms as potential risk factors for brain arteriovenous malformation development and hemorrhagic presentation.
Delev D, Pavlova A, Grote A, Boström A, Höllig A, Schramm J, Fimmers R, Oldenburg J, Simon M. | 09/7/2019 |
| In HNSCC, the NOTCH4-HEY1 pathway is specifically upregulated, induces proliferation and cisplatin resistance, and promotes EMT. | The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano JA., Free PMC Article | 07/27/2019 |
| NOTCH4 expression was negatively controlled by RUNX1 via a novel regulatory DNA element within the locus, and this work examined its involvement in megakaryocyte generation. Specific inactivation of NOTCH4 by an improved CRISPR-Cas9 system in human induced pluripotent stem cells enhanced megakaryopoiesis. | Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.
Li Y, Jin C, Bai H, Gao Y, Sun S, Chen L, Qin L, Liu PP, Cheng L, Wang QF., Free PMC Article | 05/11/2019 |