| CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1. | CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1.
Zhang B, Zhao B, Han S, Chen S. | 09/23/2023 |
| Aberrant expression of MYD88 via RNA-controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer. | Aberrant expression of MYD88 via RNA-controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer.
Tsuda M, Noguchi M, Kurai T, Ichihashi Y, Ise K, Wang L, Ishida Y, Tanino M, Hirano S, Asaka M, Tanaka S., Free PMC Article | 12/11/2021 |
| CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer. | CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer.
Zhang B, Han S, Ma H, Chen S., Free PMC Article | 12/4/2021 |
| CNOT4 suppresses non-small cell lung cancer progression and is required for effector cytolytic T lymphocytes cell responses to lung cancer cells. | CNOT4 suppresses non-small cell lung cancer progression and is required for effector cytolytic T lymphocytes cell responses to lung cancer cells.
Zhang B, Chen S. | 04/24/2021 |
| The Interplay between HGF/c-met Axis and Nox4 in BRAF Mutated Melanoma. | The Interplay between HGF/c-met Axis and Nox4 in BRAF Mutated Melanoma.
Beretti F, Farnetani F, Reggiani Bonetti L, Fabbiani L, Zavatti M, Maiorana A, Pellacani G, Maraldi T., Free PMC Article | 04/13/2021 |
| conserved RNA recognition motif and C3H1 domain of the Not4 | The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.
Chen H, Sirupangi T, Wu ZH, Johnson DL, Laribee RN., Free PMC Article | 10/12/2019 |
| Damage-induced ubiquitination of ABCE1 protein by NOT4 generates poly-ubiquitin signals that attract autophagy receptors to mitochondrial outer membrane to initiate mitophagy. | Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.
Wu Z, Wang Y, Lim J, Liu B, Li Y, Vartak R, Stankiewicz T, Montgomery S, Lu B., Free PMC Article | 09/21/2019 |
| the C-terminal regions of human and D. melanogaster NOT4 contain a conserved sequence motif that directly binds the CAF40 subunit of the CCR4-NOT complex (CAF40-binding motif [CBM]). | A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.
Keskeny C, Raisch T, Sgromo A, Igreja C, Bhandari D, Weichenrieder O, Izaurralde E., Free PMC Article | 03/2/2019 |
| These results indicate that CNOT4 is a ubiquitin ligase of influenza A virus nucleoprotein, and ubiquitination of the nucleoprotein plays a positive role in viral RNA replication. | CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication.
Lin YC, Jeng KS, Lai MMC., Free PMC Article | 02/17/2018 |
| CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome. | Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome.
Sun HY, Kim N, Hwang CS, Yoo JY., Free PMC Article | 02/6/2016 |
| Single nucleotide polymorphism in CNOT4 gene is associated with osteosarcoma susceptibility. | Polymorphisms in miRNA processing genes and their role in osteosarcoma risk.
Bilbao-Aldaiturriaga N, Gutierrez-Camino A, Martin-Guerrero I, Pombar-Gomez M, Zalacain-Diez M, Patiño-Garcia A, Lopez-Lopez E, Garcia-Orad A. | 07/25/2015 |
| Data show that Not4/CNOT4 is a novel positive regulator of the JAK/STAT pathway in Drosophila and in humans. | Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells.
Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M. | 05/26/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT4 binds CNOT1 in yeast two-hybrid assays. | Human Ccr4-Not complexes contain variable deadenylase subunits.
Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT. | 01/21/2010 |
| Data show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective | An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.
Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT. | 01/21/2010 |