| NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy. | NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy.
Dardas Z, Fatih JM, Jolly A, Dawood M, Du H, Grochowski CM, Jones EG, Jhangiani SN, Wehrens XHT, Liu P, Bi W, Boerwinkle E, Posey JE, Muzny DM, Gibbs RA, Lupski JR, Coban-Akdemir Z, Morris SA., Free PMC Article | 04/8/2024 |
| A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses. | A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses.
Coda DM, Patel H, Gori I, Gaarenstroom TE, Song OR, Howell M, Hill CS., Free PMC Article | 04/30/2022 |
| A case for revisiting Nodal signaling in human pluripotent stem cells. | A case for revisiting Nodal signaling in human pluripotent stem cells.
Hayes K, Kim YK, Pera MF. | 03/12/2022 |
| PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs. | PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.
Roudaut M, Idriss S, Caillaud A, Girardeau A, Rimbert A, Champon B, David A, Lévêque A, Arnaud L, Pichelin M, Prieur X, Prat A, Seidah NG, Zibara K, Le May C, Cariou B, Si-Tayeb K., Free PMC Article | 03/5/2022 |
| Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids. | Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.
Liu L, Nemashkalo A, Rezende L, Jung JY, Chhabra S, Guerra MC, Heemskerk I, Warmflash A., Free PMC Article | 02/26/2022 |
| Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l. | Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.
Kim HS, Green YS, Xie Y, Christian JL., Free PMC Article | 01/8/2022 |
| Normal Skin Cells Increase Aggressiveness of Cutaneous Melanoma by Promoting Epithelial-to-Mesenchymal Transition via Nodal and Wnt Activity. | Normal Skin Cells Increase Aggressiveness of Cutaneous Melanoma by Promoting Epithelial-to-Mesenchymal Transition via Nodal and Wnt Activity.
Untiveros G, Dezi L, Gillette M, Sidor J, Strizzi L., Free PMC Article | 12/18/2021 |
| Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population. | Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population.
Yadav ML, Ranjan P, Das P, Jain D, Kumar A, Mohapatra B. | 12/11/2021 |
| Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes. | Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes.
Dieters-Castator D, Dantonio PM, Piaseczny M, Zhang G, Liu J, Kuljanin M, Sherman S, Jewer M, Quesnel K, Kang EY, Köbel M, Siegers GM, Leask A, Hess D, Lajoie G, Postovit LM., Free PMC Article | 11/22/2021 |
| Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids. | Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids.
Cave DD, Hernando-Momblona X, Sevillano M, Minchiotti G, Lonardo E., Free PMC Article | 07/31/2021 |
| Aberrantly Expressed Embryonic Protein NODAL Alters Breast Cancer Cell Susceptibility to gammadelta T Cell Cytotoxicity. | Aberrantly Expressed Embryonic Protein NODAL Alters Breast Cancer Cell Susceptibility to γδ T Cell Cytotoxicity.
Siegers GM, Dutta I, Kang EY, Huang J, Köbel M, Postovit LM., Free PMC Article | 04/13/2021 |
| E2A regulates neural ectoderm fate specification in human embryonic stem cells. | E2A regulates neural ectoderm fate specification in human embryonic stem cells.
Yi S, Huang X, Zhou S, Zhou Y, Anderson MK, Zúñiga-Pflücker JC, Luan Q, Li Y., Free PMC Article | 02/2/2021 |
| Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma. | Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.
Matsumoto T, Chino H, Akiya M, Hashimura M, Yokoi A, Tochimoto M, Nakagawa M, Jiang Z, Saegusa M. | 01/23/2021 |
| Nodal plays an important role in promoting growth, proliferation and invasion in retinoblastoma. | Downregulation of Nodal inhibits metastatic progression in retinoblastoma.
Asnaghi L, White DT, Yoon L, Price A, Lee GY, Sahoo A, Mumm JS, Eberhart CG., Free PMC Article | 08/1/2020 |
| The activation of Nodal pathway downstream of Akt1 suppression promotes prostate cancer cell epithelial-to-mesenchymal transition in vitro and metastasis in vivo and therefore targeting Nodal pathway using SB505124 could serve as a potential therapeutic strategy for the treatment of metastatic prostate cancer. | Nodal pathway activation due to Akt1 suppression is a molecular switch for prostate cancer cell epithelial-to-mesenchymal transition and metastasis.
Alwhaibi A, Verma A, Artham S, Adil MS, Somanath PR., Free PMC Article | 07/18/2020 |
| we identify ISM1 as an extracellular antagonist of NODAL and reveal a negative regulatory mechanism that provides greater plasticity for the fine-tuning of NODAL signaling. | ISM1 regulates NODAL signaling and asymmetric organ morphogenesis during development.
Osório L, Wu X, Wang L, Jiang Z, Neideck C, Sheng G, Zhou Z., Free PMC Article | 05/16/2020 |
| The authors show that BMP4 response is concentration dependent, but that expression of many Nodal targets depends on rate of concentration change. Moreover, in a self-organized stem cell model for human gastrulation, expression of these genes follows rapid changes in endogenous Nodal signaling. | Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells.
Heemskerk I, Burt K, Miller M, Chhabra S, Guerra MC, Liu L, Warmflash A., Free PMC Article | 04/4/2020 |
| Nodal expression determines peri-gastrulation-associated versus preneurulation-associated fate patterning of pluripotent stem cells. | High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation-associated versus preneurulation-associated fate patterning.
Tewary M, Dziedzicka D, Ostblom J, Prochazka L, Shakiba N, Heydari T, Aguilar-Hidalgo D, Woodford C, Piccinini E, Becerra-Alonso D, Vickers A, Louis B, Rahman N, Danovi D, Geens M, Watt FM, Zandstra PW., Free PMC Article | 02/29/2020 |
| The study showed that the dynamics of signaling events in the BMP4, WNT, and NODAL cascade in the absence of a stable signaling gradient control fate patterning of human gastruloids. | Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids.
Chhabra S, Liu L, Goh R, Kong X, Warmflash A., Free PMC Article | 02/29/2020 |
| found that Nodal can increase the proliferation and decrease chemosensitivity of NSCLC cells via regulation of NF-kappaB/IL-6 signals. It indicated that Nodal might be a potential therapeutic target for NSCLC treatment | Nodal promotes the malignancy of non-small cell lung cancer (NSCLC) cells via activation of NF-κB/IL-6 signals.
Xu X, Zhou X, Gao C, Cao L, Zhang Y, Hu X, Cui Y. | 02/22/2020 |
| Loss of MNK1 repressed NODAL expression, inhibited ductal carcinoma in situ to invasive ductal carcinoma conversion, and decreased tumor relapse and metastasis | MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ.
Guo Q, Li VZ, Nichol JN, Huang F, Yang W, Preston SEJ, Talat Z, Lefrère H, Yu H, Zhang G, Basik M, Gonçalves C, Zhan Y, Plourde D, Su J, Torres J, Marques M, Habyan SA, Bijian K, Amant F, Witcher M, Behbod F, McCaffrey L, Alaoui-Jamali M, Giannakopoulos NV, Brackstone M, Postovit LM, Del Rincón SV, Miller WH Jr., Free PMC Article | 01/4/2020 |
| NODAL polymorphisms were not associated with preterm birth. However, the rs2231947(C>T) variant allele was associated with increased risk for preterm birth among women with bacterial vaginosis. The effect of NODAL polymorphisms on preterm birth depends on maternal infection/inflammation status. | Evidence of a gene-environment interaction of NODAL variants and inflammation in preterm birth.
Starr LM, Ayash TA, Dufort D. | 10/5/2019 |
| Data found significant upregulation of Nodal expression in ovarian endometriosis-ovarian clear cell carcinoma (OCCCa) lesions, when compared with other ovarian epithelial carcinoma (OECa) histological subtypes. An association was found between TGF-beta/Smad signaling and the functional role of Nodal with regard to the rate of tumor cell apoptosis and proliferation in the OCCCa lesions. | Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions.
Miura R, Yokoi A, Matsumoto T, Oguri Y, Hashimura M, Tochimoto M, Kajita S, Saegusa M., Free PMC Article | 08/3/2019 |
| Extracellular Nodal is confined underneath the cells, resulting in a narrow distribution compared with Lefty. | Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty.
Sekine R, Shibata T, Ebisuya M., Free PMC Article | 02/23/2019 |
| NODAL signaling is regulated by MicroRNA-454 in the placental tissues from pre-eclampsia patients.MiR-454 regulates Nodal signaling in trophoblast cells via AKL7. | MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia.
Shi Z, She K, Li H, Yuan X, Han X, Wang Y. | 01/12/2019 |