| SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway. | SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway.
Qiu P, Li X, Gong M, Wen P, Wen J, Xu L, Wang G., Free PMC Article | 03/30/2023 |
| N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas. | N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas.
Zhang T, Goel A, Xu X, Wu Y, Tang E, Zhang F, Li Y, Li H, Cai Y, Weng W. | 08/20/2022 |
| N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression. | N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.
Sun Y, Guan Z, Sheng Q, Duan W, Zhao H, Zhou J, Deng Q, Pei X. | 02/26/2022 |
| mTOR, a downstream target of PKB/Akt, regulates NMT1 in ER positive breast cancer cells (MCF7 cells). NMT1 increased with rapamycin treatment over the period of time with a concomitant decrease in mTOR phosphorylation. | Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.
Jacquier M, Kuriakose S, Bhardwaj A, Zhang Y, Shrivastav A, Portet S, Varma Shrivastav S., Free PMC Article | 12/21/2019 |
| inhibition of NMT1 caused degraded proteins increase and ER stress, which cross-talked with mitochondria to produce more ROS. And both of oxidative stress and ER stress could activate JNK pathway, leading to autophagy which abrogated breast cancer progression especially triple-negative breast cancer (TNBC). | NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.
Deng L, Gao X, Liu B, He X, Xu J, Qiang J, Wu Q, Liu S., Free PMC Article | 12/14/2019 |
| Data showed that rheumatoid arthritis (RA) T cells had a defect in type I N-myristoyltransferase (NMT1) function, which prevented AMP-activated protein kinase (AMPK) activation. | N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation.
Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM., Free PMC Article | 05/4/2019 |
| Genetic and pharmacologic evidence that inhibiting the N-myristoyltransferase NMT1 suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells. | Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.
Kim S, Alsaidan OA, Goodwin O, Li Q, Sulejmani E, Han Z, Bai A, Albers T, Beharry Z, Zheng YG, Norris JS, Szulc ZM, Bielawska A, Lebedyeva I, Pegan SD, Cai H., Free PMC Article | 01/6/2018 |
| These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 at the ER membrane. | N-Myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum.
Dudek E, Millott R, Liu WX, Beauchamp E, Berthiaume LG, Michalak M. | 04/23/2016 |
| findings suggest that both NMT1 and hnRNP A2/B1 take part in the regulation of HIV-1 RNA expression through their mutual opposite effects on the viral RNA expression in HIV-1-producing cells | N-Myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level.
Ohta H, Takamune N, Kishimoto N, Shoji S, Misumi S. | 11/7/2015 |
| we propose a model of the Nef:NMT complex in which only the myristoyl moiety holds the two proteins together in complex and speculate that perhaps NMT chaperones Nef to the membrane and thereby protects the myristic acid group from the cytosol | Effects of HIV-1 Nef on human N-myristoyltransferase 1.
Morgan CR, Miglionico BV, Engen JR., Free PMC Article | 06/18/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These results strongly suggest that HIV-1 production is specifically associated with hNMT1, particularly hNMT1(L), but not with hNMT2 in vivo, contributing to the understanding of a step in HIV-1 replication. | HIV-1 production is specifically associated with human NMT1 long form in human NMT isozymes.
Takamune N, Gota K, Misumi S, Tanaka K, Okinaka S, Shoji S. | 01/21/2010 |
| N-myristoyltransferase may have a role in progression of colonic neoplasms | N-myristoyltransferase: a potential novel diagnostic marker for colon cancer.
Shrivastav A, Varma S, Saxena A, DeCoteau J, Sharma RK., Free PMC Article | 01/21/2010 |
| Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence. | N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef.
Seaton KE, Smith CD., Free PMC Article | 01/21/2010 |
| Elevated N-myristoyltransferase activity is associated with oral squamous cell carcinoma | Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma.
Shrivastav A, Sharma AR, Bajaj G, Charavaryamath C, Ezzat W, Spafford P, Gore-Hickman R, Singh B, Copete MA, Sharma RK. | 01/21/2010 |
| In this study, we found decreases in the mRNA levels of human NMT isoforms and the NMT activities in the course of HIV-1 infection in the human T-cell line | Novel strategy for anti-HIV-1 action: selective cytotoxic effect of N-myristoyltransferase inhibitor on HIV-1-infected cells.
Takamune N, Hamada H, Misumi S, Shoji S. | 01/21/2010 |
| role of HSC70 in the regulation of NMT | N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70.
Selvakumar P, Lakshmikuttyamma A, Pasha MK, King MJ, Olson DJ, Mori S, Ross AR, Hayashi K, Dimmock JR, Sharma RK. | 01/21/2010 |
| NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation | Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
Ducker CE, Upson JJ, French KJ, Smith CD., Free PMC Article | 01/21/2010 |