| Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future. | Polymorphisms and Pharmacogenomics of NQO2: The Past and the Future.
Janda E, Boutin JA, De Lorenzo C, Arbitrio M., Free PMC Article | 01/31/2024 |
| An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma. | An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma.
Nakashima C, Fujiwara-Tani R, Mori S, Kishi S, Ohmori H, Fujii K, Mori T, Miyagawa Y, Yamamoto K, Kirita T, Luo Y, Kuniyasu H., Free PMC Article | 10/15/2022 |
| Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity. | Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity.
Megarity CF, Timson DJ., Free PMC Article | 09/19/2020 |
| these data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to reactive oxygen species-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals | Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2.
Cassagnes LE, Chhour M, Pério P, Sudor J, Gayon R, Ferry G, Boutin JA, Nepveu F, Reybier K. | 06/29/2019 |
| The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2). | The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2).
Riches Z, Liu Y, Berman JM, Walia G, Collier AC. | 12/23/2017 |
| In patients with Alzheimer's disease, QR2 is overexpressed in the insular cotex. | Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.
Rappaport AN, Jacob E, Sharma V, Inberg S, Elkobi A, Ounallah-Saad H, Pasmanik-Chor M, Edry E, Rosenblum K., Free PMC Article | 03/19/2016 |
| NQO2-L47 is less stable towards proteolytic digestion and thermal denaturation than NQO2-F47. | The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.
Megarity CF, Gill JR, Caraher MC, Stratford IJ, Nolan KA, Timson DJ., Free PMC Article | 06/28/2014 |
| NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population. | Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.
Umar M, Upadhyay R, Kumar S, Ghoshal UC, Mittal B. | 06/29/2013 |
| This first structure of a reduced quinone reductase shows that reduction of the FAD cofactor and binding of a specific inhibitor lead to global changes in NQO2 structure and is consistent with a functional role for NQO2 as a flavin redox switch. | Chloroquine binding reveals flavin redox switch function of quinone reductase 2.
Leung KK, Shilton BH., Free PMC Article | 06/15/2013 |
| Diplotypes of NQO1 (exon 4 and 6), C-T (OR = 1.56, Pc = 0.007) and T-T (OR = 0.011, Pc = 3.86) was associated with an increased risk for prostate cancer (PCa). NQO2 and MTHFR did not show any risk with PCa. | Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.
Mandal RK, Nissar K, Mittal RD. | 04/6/2013 |
| both NQO1 and NQO2 modulate the efficacy of AC therapy and that NQO2 is associated with tamoxifen toxicity. | Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy.
Jamieson D, Cresti N, Bray J, Sludden J, Griffin MJ, Hawsawi NM, Famie E, Mould EV, Verrill MW, May FE, Boddy AV. | 06/16/2012 |
| results indicate a role of NQO2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol | Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells.
Hsieh TC, Yang CJ, Lin CY, Lee YS, Wu JM., Free PMC Article | 05/12/2012 |
| Results suggest that NQO2, SOD2 and SOD3 may significantly modify prognosis of breast cancer patients. | Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas.
Hubackova M, Vaclavikova R, Ehrlichova M, Mrhalova M, Kodet R, Kubackova K, Vrána D, Gut I, Soucek P. | 03/17/2012 |
| results suggest that the increase in hippocampal QR2 might be a cause of AD or might promote the progression of AD by causing an increase in the toxic quinone levels and consequent loss of cognitive function. | Increased hippocampal quinone reductase 2 in Alzheimer's disease.
Hashimoto T, Nakai M. | 01/7/2012 |
| Selective inhibition of NQO2 over NQO1 can be attributed to the bulky aminoalkylamino substituent at the 5-position, which blocks entrance of the indolequinones into the NQO1 active site. | Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.
Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D., Free PMC Article | 11/26/2011 |
| NQO2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| The NQO1 609C>T TT genotype and T allele were significantly associated with increased risk for gastric cancer (GC), whereas NQO2 -3423G>A polymorphism did not show any association with GC. | Role of NQO1 609C>T and NQO2-3423G>A polymorphisms in susceptibility to gastric cancer in Kashmir valley.
Malik MA, Zargar SA, Mittal B. | 07/16/2011 |
| The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. | Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.
Mohelnikova-Duchonova B, Marsakova L, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, Slamova A, Schejbalova M, Soucek P, Mohelnikova-Duchonova B, Marsakova L, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, Slamova A, Schejbalova M, Soucek P. | 04/23/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations.
Ji LD, Xu J, Wu DD, Xie SD, Tang NL, Zhang YP. | 04/7/2010 |
| We observed a nominal significant association between the rs1143684 NQO2 polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities. | Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline.
Payton A, Miyajima F, Ollier W, Rabbitt P, Pickles A, Weiss V, Pendleton N, Horan M. | 03/22/2010 |
| Our findings challenge the previous assumption that the NQo2 I-16 allele is stable only when paired with another I-16 allele | Caution regarding genotyping methodology for a tri-allelic polymorphism in the novel breast cancer susceptibility gene NQO2.
Yu KD, Di GH, Fan L, Hu Z, Chen AX, Shao ZM. | 01/25/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial.
Choi JY, Barlow WE, Albain KS, Hong CC, Blanco JG, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Osborne CK, Abeloff MD, Hayes DF, Ambrosone CB., Free PMC Article | 09/16/2009 |
| NQO2 is a susceptibility gene for breast carcinogenesis. | Functional polymorphisms, altered gene expression and genetic association link NRH:quinone oxidoreductase 2 to breast cancer with wild-type p53.
Yu KD, Di GH, Yuan WT, Fan L, Wu J, Hu Z, Shen ZZ, Zheng Y, Huang W, Shao ZM. | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesSuperoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.
Mohelnikova-Duchonova B, Marsakova L, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, Slamova A, Schejbalova M, Soucek P, Mohelnikova-Duchonova B, Marsakova L, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, Slamova A, Schejbalova M, Soucek P. Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai.
Wen H, Ding Q, Fang ZJ, Xia GW, Fang J. | 04/22/2009 |