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    ATP1B3 ATPase Na+/K+ transporting subunit beta 3 [ Homo sapiens (human) ]

    Gene ID: 483, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [Screening and identification of key genes ATP1B3 and ENAH in the progression of hepatocellular carcinoma: based on data mining and clinical validation].

    [Screening and identification of key genes ATP1B3 and ENAH in the progression of hepatocellular carcinoma: based on data mining and clinical validation].
    Yang X, Li Y, Wu D, Ma Y, Zhou S., Free PMC Article

    07/16/2022
    Integrative Transcriptomic, Proteomic and Functional Analysis Reveals ATP1B3 as a Diagnostic and Potential Therapeutic Target in Hepatocellular Carcinoma.

    Integrative Transcriptomic, Proteomic and Functional Analysis Reveals ATP1B3 as a Diagnostic and Potential Therapeutic Target in Hepatocellular Carcinoma.
    Lu S, Cai S, Peng X, Cheng R, Zhang Y., Free PMC Article

    10/30/2021
    ATP1B3 Restricts Hepatitis B Virus Replication Via Reducing the Expression of the Envelope Proteins.

    ATP1B3 Restricts Hepatitis B Virus Replication Via Reducing the Expression of the Envelope Proteins.
    Zhang J, Zheng T, Zhou X, Wang H, Li Z, Huan C, Zheng B, Zhang W., Free PMC Article

    10/23/2021
    These results demonstrate that CASPR1 binds with ATP1B3 and thereby contributes to the regulation of Na(+)/K(+)-ATPase maturation and trafficking to the plasma membrane in brain microvascular endothelial cells.

    A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na(+)/K(+)-ATPase in brain microvascular endothelial cells.
    Zhang SH, Liu DX, Wang L, Li YH, Wang YH, Zhang H, Su ZK, Fang WG, Qin XX, Shang DS, Li B, Han XN, Zhao WD, Chen YH., Free PMC Article

    10/19/2019
    ligation of the Na, K ATPase beta3 subunit on monocytes by mAb P-3E10 arbitrated T cell hypofunction. This mAb might be a promising novel immunotherapeutic antibody for the treatment of hyperresponsive T cell associated diseases.

    Ligation of Na, K ATPase β3 subunit on monocytes by a specific monoclonal antibody mediates T cell hypofunction.
    Takheaw N, Laopajon W, Surinkaew S, Khummuang S, Pata S, Kasinrerk W., Free PMC Article

    12/22/2018
    Our study demonstrated that ATP1B3 inhibit EV71 replication by enhancing the production of type-I interferons, which could act as a potential therapeutic target in EV71 infection.

    ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons.
    Lu Y, Hou H, Wang F, Qiao L, Wang X, Yu J, Liu W, Sun Z., Free PMC Article

    05/7/2017
    Data suggest that ATP1B3 is binding partner of BST-2 and regulates stability of BST-2; ATP1B3 is co-factor that accelerates BST-2 degradation and reduces BST-2-mediated restriction of HIV-1 replication/tropism and NFkappaB activation.

    ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor κ Light Chain Enhancer of Activated B Cells (NF-κB) Activation by BST-2.
    Nishitsuji H, Sugiyama R, Abe M, Takaku H., Free PMC Article

    08/6/2016
    B7H3 and ATP1B3 are overexpressed in tumor endothelial cells, favoring an angiogenic phenotype.

    Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues.
    Mesri M, Birse C, Heidbrink J, McKinnon K, Brand E, Bermingham CL, Feild B, Fitzhugh W, He T, Ruben S, Moore PA., Free PMC Article

    09/6/2014
    Elevated Na+ -K+ -ATPase activity postexercise may contribute to reduced fatigue after training.

    Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.
    Aughey RJ, Murphy KT, Clark SA, Garnham AP, Snow RJ, Cameron-Smith D, Hawley JA, McKenna MJ.

    01/21/2010
    role in T and B lymphocyte activation

    Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation.
    Chiampanichayakul S, Szekeres A, Khunkaewla P, Moonsom S, Leksa V, Drbal K, Zlabinger GJ, Hofer-Warbinek R, Stockinger H, Kasinrerk W.

    01/21/2010
    These results evidenced that the beta3 subunit of Na, K ATPase is expressed on RBC membrane but the epitope recognized by mAb P-3E10 is hidden in normal RBCs. we showed the association of beta3 subunit and alpha subunit of Na, K ATPase.

    Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells.
    Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W.

    01/21/2010
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