| Understanding the impact of structural modifications at the NNAT gene's post-translational acetylation site: in silico approach for predicting its drug-interaction role in anorexia nervosa. | Understanding the impact of structural modifications at the NNAT gene's post-translational acetylation site: in silico approach for predicting its drug-interaction role in anorexia nervosa.
Azmi MB, Jawed A, Ahmed SDH, Naeem U, Feroz N, Saleem A, Sardar K, Qureshi SA, Azim MK., Free PMC Article | 11/22/2023 |
| NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer. | NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer.
Plasterer C, Semenikhina M, Tsaih SW, Flister MJ, Palygin O., Free PMC Article | 07/10/2023 |
| DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway. | DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
Deng Y, Lu L, Liang X, Li J, Zhu D, Huang H, Zhang Y, Zhang X, Chen Y, Liu X, Fu Y. | 12/31/2022 |
| In silico identification of the rare-coding pathogenic mutations and structural modeling of human NNAT gene associated with anorexia nervosa. | In silico identification of the rare-coding pathogenic mutations and structural modeling of human NNAT gene associated with anorexia nervosa.
Azmi MB, Naeem U, Saleem A, Jawed A, Usman H, Qureshi SA, Azim MK. | 10/22/2022 |
| The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer. | The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer.
Pieper W, Ignatov A, Kalinski T, Haybaeck J, Czapiewski P, Nass N. | 02/5/2022 |
| NNAT variants and NNAT expression changes may be associated with susceptibility to eating disorders such as anorexia nervosa. | Anorexia nervosa is associated with Neuronatin variants.
Lombardi L, Blanchet C, Poirier K, Lebrun N, Ramoz N, Rose Moro M, Gorwood P, Bienvenu T. | 02/8/2020 |
| The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer. | Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations.
Oczko-Wojciechowska M, Swierniak M, Krajewska J, Kowalska M, Kowal M, Stokowy T, Wojtas B, Rusinek D, Pawlaczek A, Czarniecka A, Szpak-Ulczok S, Gawlik T, Chmielik E, Tyszkiewicz T, Nikiel B, Lange D, Jarzab M, Wiench M, Jarzab B., Free PMC Article | 10/27/2018 |
| Data suggest NNAT as a potential tumor suppressor in myxoid liposarcomas. | Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.
Renner M, Wolf T, Meyer H, Hartmann W, Penzel R, Ulrich A, Lehner B, Hovestadt V, Czwan E, Egerer G, Schmitt T, Alldinger I, Renker EK, Ehemann V, Eils R, Wardelmann E, Büttner R, Lichter P, Brors B, Schirmacher P, Mechtersheimer G., Free PMC Article | 04/25/2015 |
| Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss. | Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
Joseph RM. | 12/20/2014 |
| indicate that Nnat is related to keratinocyte differentiation by up-regulating involucrin expression | Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
Dugu L, Nakahara T, Wu Z, Uchi H, Liu M, Hirano K, Yokomizo T, Furue M. | 10/18/2014 |
| methylation status of a not-yet-described regulatory element within the NNAT locus that contains four potential CTCF binding sites determines the expression level of NNAT | Selective methylation of CpGs at regulatory binding sites controls NNAT expression in Wilms tumors.
Hubertus J, Zitzmann F, Trippel F, Müller-Höcker J, Stehr M, von Schweinitz D, Kappler R., Free PMC Article | 02/8/2014 |
| Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease | Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease.
Sharma J, Mukherjee D, Rao SN, Iyengar S, Shankar SK, Satishchandra P, Jana NR., Free PMC Article | 06/1/2013 |
| Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival. | Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival.
Xu DS, Yang C, Proescholdt M, Bründl E, Brawanski A, Fang X, Lee CS, Weil RJ, Zhuang Z, Lonser RR., Free PMC Article | 09/22/2012 |
| A stringent analysis identified NNAT as a key imprinted gene that was dysregulated in induced pluripotent stem cells. | Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells.
Teichroeb JH, Betts DH, Vaziri H., Free PMC Article | 02/18/2012 |
| malin negatively regulates neuronatin and its loss of function in Lafora disease results in increased accumulation of neuronatin | Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis.
Sharma J, Rao SN, Shankar SK, Satishchandra P, Jana NR. | 12/3/2011 |
| A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity | The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.
Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Sjöström L, Carlsson LM, Liu Y, Liu X, Deng HW, Larsen PJ., Free PMC Article | 10/4/2010 |
| Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma. | Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma.
Revill K, Dudley KJ, Clayton RN, McNicol AM, Farrell WE. | 01/21/2010 |
| frequently observed overexpression of both neuronatin splice forms in medulloblastomaenhances growth in this cancer | Coexpression of neuronatin splice forms promotes medulloblastoma growth.
Siu IM, Bai R, Gallia GL, Edwards JB, Tyler BM, Eberhart CG, Riggins GJ., Free PMC Article | 01/21/2010 |
| Neuronatin expression is associated with poor prognosis in patients with adenocarcinoma, and may be useful as a prognostic marker for lung adenocarcinoma. | Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma.
Uchihara T, Okubo C, Tanaka R, Minami Y, Inadome Y, Iijima T, Morishita Y, Fujita J, Noguchi M. | 01/21/2010 |
| Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia | Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia.
Kuerbitz SJ, Pahys J, Wilson A, Compitello N, Gray TA. | 01/21/2010 |