| Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level. | Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level.
Liu P, Xing N, Xiahou Z, Yan J, Lin Z, Zhang J., Free PMC Article | 03/25/2024 |
| NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2. | NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.
Zhang Y, Huang H, Liu P, Xie Y. | 10/25/2023 |
| Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and Regulate Doxorubicin Resistance in Lymphoma Cells. | Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and Regulate Doxorubicin Resistance in Lymphoma Cells.
Feng L, Yan Q, Xu X. | 05/24/2023 |
| Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients. | Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients.
Lu T, Li C, Xiang C, Gong Y, Peng W, Hou F, Chen C., Free PMC Article | 10/29/2022 |
| NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma. | NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.
Feng L, Xu X, Zhao K. | 01/15/2022 |
| The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC. | NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling.
Fang Z, Gong C, Yu S, Zhou W, Hassan W, Li H, Wang X, Hu Y, Gu K, Chen X, Hong B, Bao Y, Chen X, Zhang X, Liu H. | 10/27/2018 |
| Data indicate that specific cancer-driving nodes are generally under NF-YA/B control. | NF-Y activates genes of metabolic pathways altered in cancer cells.
Benatti P, Chiaramonte ML, Lorenzo M, Hartley JA, Hochhauser D, Gnesutta N, Mantovani R, Imbriano C, Dolfini D., Free PMC Article | 12/17/2016 |
| Presence of NF-Y transcription factor plays a pivotal role in transcriptional regulation of ID genes in development. | Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.
Moeinvaziri F, Shahhoseini M. | 10/22/2016 |
| NF-YB transcription factor was identified as a novel direct E2F1 target. | E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.
Jiang X, Nevins JR, Shats I, Chi JT., Free PMC Article | 05/7/2016 |
| The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif. | NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.
Fleming JD, Pavesi G, Benatti P, Imbriano C, Mantovani R, Struhl K., Free PMC Article | 02/22/2014 |
| The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA both binds to NF-YB/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box. | Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.
Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R. | 03/23/2013 |
| Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia. | Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.
Nakamura S, Nagata Y, Tan L, Takemura T, Shibata K, Fujie M, Fujisawa S, Tanaka Y, Toda M, Makita R, Tsunekawa K, Yamada M, Yamaoka M, Yamashita J, Ohnishi K, Yamashita M., Free PMC Article | 04/7/2012 |
| NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L | NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters.
Fossati A, Dolfini D, Donati G, Mantovani R., Free PMC Article | 08/6/2011 |
| MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha. | Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness.
Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, Beck WT., Free PMC Article | 06/4/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
Campa D, Hüsing A, Chang-Claude J, Dostal L, Boeing H, Kröger J, Tjønneland A, Roswall N, Overvad K, Dahm CC, Rodríguez L, Sala N, Pérez MJ, Larrañaga N, Chirlaque MD, Ardanaz E, Khaw KT, Wareham N, Allen NE, Travis RC, Trichopoulou A, Naska A, Bamia C, Palli D, Sieri S, Tumino R, Sacerdote C, van Kranen HJ, Bas Bueno-de-Mesquita H, Stattin P, Johansson M, Chajes V, Rinaldi S, Romieu I, Siddiq A, Norat T, Riboli E, Kaaks R, Canzian F. | 12/5/2010 |
| CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization | In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences.
Raju CS, Göritz C, Nord Y, Hermanson O, López-Iglesias C, Visa N, Castelo-Branco G, Percipalle P., Free PMC Article | 01/21/2010 |
| trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation. | CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A.
Kang JH, Kim MJ, Chang SY, Sim SS, Kim MS, Jo YH. | 01/21/2010 |
| Observational study of genetic testing. (HuGE Navigator) | A flexible array format for large-scale, rapid blood group DNA typing.
Hashmi G, Shariff T, Seul M, Vissavajjhala P, Hue-Roye K, Charles-Pierre D, Lomas-Francis C, Chaudhuri A, Reid ME. | 03/13/2008 |
| Histone deacetylase inhibitors can induce Gadd45 through its promoter without the need for functional p53, and both Oct-1 and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 promoter. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.
Hirose T, Sowa Y, Takahashi S, Saito S, Yasuda C, Shindo N, Furuichi K, Sakai T. | 01/21/2010 |
| CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region | The transcription factor CCAAT-binding factor CBF/NF-Y regulates the proximal promoter activity in the human alpha 1(XI) collagen gene (COL11A1).
Matsuo N, Yu-Hua W, Sumiyoshi H, Sakata-Takatani K, Nagato H, Sakai K, Sakurai M, Yoshioka H. | 01/21/2010 |
| The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. | The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
Romier C, Cocchiarella F, Mantovani R, Moras D. | 01/21/2010 |
| p53 negatively regulates Chk2 gene transcription through modulation of NF-Y function and that this regulation may be important for reentry of cells into the cell cycle after DNA damage is repaired. | Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y.
Matsui T, Katsuno Y, Inoue T, Fujita F, Joh T, Niida H, Murakami H, Itoh M, Nakanishi M. | 01/21/2010 |
| p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function | Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.
Salsi V, Caretti G, Wasner M, Reinhard W, Haugwitz U, Engeland K, Mantovani R. | 01/21/2010 |
| Co-operative functional interactions between Sp1 & NF-Y are required to direct the activity of the ATP1A3 promoter predominantly in neuronal cells. | The expression of the human neuronal alpha3 Na+,K+-ATPase subunit gene is regulated by the activity of the Sp1 and NF-Y transcription factors.
Benfante R, Antonini RA, Vaccari M, Flora A, Chen F, Clementi F, Fornasari D., Free PMC Article | 01/21/2010 |