| High expression of NFX1-123 in HPV positive head and neck squamous cell carcinomas. | High expression of NFX1-123 in HPV positive head and neck squamous cell carcinomas.
Chintala S, Quist KM, Gonzalez-DeWhitt PA, Katzenellenbogen RA., Free PMC Article | 01/29/2022 |
| we found that NFX1-123 was a bona fide substrate of the deubiquitinase USP9X and that it could be degraded by the ubiquitin-proteasome system. The present study provided new insight into understanding the biological function of USP9X by targeting its substrate NFX1-123. | Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.
Chen X, Lu D, Gao J, Zhu H, Zhou Y, Gao D, Zhou H. | 05/30/2020 |
| initial mRNP binding to the NPC did not require NXF1 in the NPC, whereas release into the cytoplasm did. NXF1 localization in the NPC did not require RNA or RNA binding. Superresolution microscopy showed that NXF1 consistently occupied positions on the cytoplasmic side of the NPC. | Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.
Ben-Yishay R, Mor A, Shraga A, Ashkenazy-Titelman A, Kinor N, Schwed-Gross A, Jacob A, Kozer N, Kumar P, Garini Y, Shav-Tal Y., Free PMC Article | 05/16/2020 |
| Results indicate that NFX1-123 is markedly increased in cervical cancer, its greater expression in 16E6 expressing cells is associated with improved growth and telomerase activity, and that this association is maintained in HPV 16 positive cervical cancer cell lines. | NFX1-123 is highly expressed in cervical cancer and increases growth and telomerase activity in HPV 16E6 expressing cells.
Vliet-Gregg PA, Robinson KL, Levan J, Matsumoto LR, Katzenellenbogen RA., Free PMC Article | 01/25/2020 |
| NFX1-123 in mediating epithelial differentiation through the JNK signaling pathway. | HPV type 16 E6 and NFX1-123 augment JNK signaling to mediate keratinocyte differentiation and L1 expression.
Levan J, Vliet-Gregg PA, Robinson KL, Matsumoto LR, Katzenellenbogen RA., Free PMC Article | 10/26/2019 |
| This study identifies NFX1-123 as a critical host protein partner through which 16E6 is able to subvert the immune response and in turn permit a long-lived high-risk Human papillomavirus infection. | Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes.
Levan J, Vliet-Gregg PA, Robinson KL, Katzenellenbogen RA., Free PMC Article | 12/2/2017 |
| The results showed that a repressor complex composed of NFX1-91, mSin3A and histone deacetylase 1 was involved in the PKC-delta-induced repression of the hTERT promoter, which resulted in the repression of hTERT transcription. | Involvement of the NFX1-repressor complex in PKC-δ-induced repression of hTERT transcription.
Yamashita S, Fujii K, Zhao C, Takagi H, Katakura Y., Free PMC Article | 02/4/2017 |
| Human papillomavirus 16 E6 (16E6) interacts with the cellular protein NFX1-123, and they collaboratively increase the growth and differentiation master regulator, Notch1. | Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.
Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA., Free PMC Article | 06/27/2015 |
| NFX1-123 and human papillomavirus 16E6 upregulated Notch 1 expression in keratinocytes. | NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA., Free PMC Article | 02/8/2014 |
| a mechanism for HPV16 E6 activation of the NFkappaB pathway through NFX1-91 | NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.
Xu M, Katzenellenbogen RA, Grandori C, Galloway DA., Free PMC Article | 11/6/2010 |
| NFX1-123 is a cytoplasmic protein that colocalizes with poly(A) binding proteins, and binds hTERT mRNA in HPV16 E6-expressing keratinocytes. | NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.
Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA., Free PMC Article | 01/21/2010 |
| These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription. | NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA., Free PMC Article | 01/21/2010 |
| Nrf1 is normally targeted to the endoplasmic reticulum membrane and endoplasmic reticulum stress may play a role in modulating Nrf1 function as a transcriptional activator | Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.
Wang W, Chan JY. | 01/21/2010 |
| the induction of hTERT telomerase by the HPV-16 E6/E6-AP complex involves targeting of NFX1-91, a newly identified repressor of telomerase, for ubiquitination and degradation. | Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.
Gewin L, Myers H, Kiyono T, Galloway DA., Free PMC Article | 01/21/2010 |
| HuD acts as a novel adaptor protein to recruit TAP for efficient export of ARE-containing mRNAs in neuronal cells | TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.
Saito K, Fujiwara T, Katahira J, Inoue K, Sakamoto H. | 01/21/2010 |
| data suggest that NFX1-123 is integral to hTERT regulation in HPV16 E6-expressing epithelial cells and that the interaction between NFX1-123 and poly(A) binding proteins is critical to hTERT activity | NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, Gewin LC, Gafken PR, Galloway DA., Free PMC Article | 01/21/2010 |