| Greatwall-Endos-PP2A/B55[Twins] network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition. | Greatwall-Endos-PP2A/B55(Twins) network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.
Rangone H, Bond L, Weil TT, Glover DM. | 07/9/2024 |
| Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila. | Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila.
Emond-Fraser V, Larouche M, Kubiniok P, Bonneil É, Li J, Bourouh M, Frizzi L, Thibault P, Archambault V., Free PMC Article | 07/24/2023 |
| This work establishes Drosophila as a powerful model to further dissect the molecular mechanisms of NER and suggests additional roles of PP2A-Tws in the completion of meiosis and mitosis. | PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila.
Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox PS, Swan A, Archambault V., Free PMC Article | 09/28/2019 |
| Mutations in tws cause high frequencies of chromosome aberrations. Tws is required for activation of the G2/M DNA damage checkpoint. | A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity.
Merigliano C, Marzio A, Renda F, Somma MP, Gatti M, Vernì F., Free PMC Article | 05/6/2017 |
| Our results indicate that the cyclic changes in Gwl localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A-Tws enzymes | Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle.
Wang P, Larouche M, Normandin K, Kachaner D, Mehsen H, Emery G, Archambault V., Free PMC Article | 12/17/2016 |
| This mechanism explains simultaneously how PP2A-B55 and Gwl together regulate phosphorylated Endos, and how phosphorylated Endos controls PP2A-B55. | Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.
Williams BC, Filter JJ, Blake-Hodek KA, Wadzinski BE, Fuda NJ, Shalloway D, Goldberg ML., Free PMC Article | 02/13/2016 |
| The PP2A complex plays a novel role in differentiating tissues to promote developmentally controlled quiescence through the regulation of Cyclin E/Cdk2 activity. | Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila.
Sun D, Buttitta L., Free PMC Article | 12/5/2015 |
| Drosophila protein PP2A is a liprin-alpha-interacting protein that mediates interaction between the two proteins. | Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.
Li L, Tian X, Zhu M, Bulgari D, Böhme MA, Goettfert F, Wichmann C, Sigrist SJ, Levitan ES, Wu C., Free PMC Article | 08/16/2014 |
| We conclude that the balanced antagonism between NAP1 and PP2A controls cohesin dissociation during mitosis | Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
Moshkin YM, Doyen CM, Kan TW, Chalkley GE, Sap K, Bezstarosti K, Demmers JA, Ozgur Z, van Ijcken WF, Verrijzer CP., Free PMC Article | 03/22/2014 |
| E4orf4 has a role in inducing PP2A- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster | E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.
Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T., Free PMC Article | 07/20/2013 |
| greatwall protein antagonizes protein phosphatase 2A function in both meiosis and mitosis | PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos.
Wang P, Pinson X, Archambault V., Free PMC Article | 12/24/2011 |
| Greatwall and Endos act to promote the inactivation of PP2A-Twins/B55 in Drosophila | Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis.
Rangone H, Wegel E, Gatt MK, Yeung E, Flowers A, Debski J, Dadlez M, Janssens V, Carpenter AT, Glover DM., Free PMC Article | 12/24/2011 |
| PP2A-B' knockout flies have elevated S6K phosphorylation and exhibit phenotypes typical of elevated insulin signaling such as reduced total body triglycerides and reduced longevity. | PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.
Hahn K, Miranda M, Francis VA, Vendrell J, Zorzano A, Teleman AA. | 08/9/2010 |
| Data demonstrate that PP2A is required for Wnt/beta-catenin signaling in Drosophila. | PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.
Zhang W, Yang J, Liu Y, Chen X, Yu T, Jia J, Liu C., Free PMC Article | 01/21/2010 |
| posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A (wdb and tws) | Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Sathyanarayanan S, Zheng X, Xiao R, Sehgal A. | 01/21/2010 |
| Tws is required for the stabilization of Armadillo/beta-catenin in response to Wg/Wnt signaling. | Drosophila Twins regulates Armadillo levels in response to Wg/Wnt signal.
Bajpai R, Makhijani K, Rao PR, Shashidhara LS. | 01/21/2010 |