| ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides. | ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides.
Cerella C, Gajulapalli SR, Lorant A, Gerard D, Muller F, Lee Y, Kim KR, Han BW, Christov C, Récher C, Sarry JE, Dicato M, Diederich M., Free PMC Article | 01/12/2024 |
| ATP1A1-linked diseases require a malfunctioning protein product from one allele. | ATP1A1-linked diseases require a malfunctioning protein product from one allele.
Spontarelli K, Young VC, Sweazey R, Padro A, Lee J, Bueso T, Hernandez RM, Kim J, Katz A, Rossignol F, Turner C, Wilczewski CM, Maxwell GL, Holmgren M, Bailoo JD, Yano ST, Artigas P. | 12/15/2023 |
| Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma. | Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma.
Rajan PK, Udoh US, Nakafuku Y, Pierre SV, Sanabria J., Free PMC Article | 11/28/2023 |
| Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer. | Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer.
Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E. | 09/21/2023 |
| Silencing of ATP1A1 attenuates cell membrane disruption by nanosecond electric pulses. | Silencing of ATP1A1 attenuates cell membrane disruption by nanosecond electric pulses.
Silkuniene G, Mangalanathan UM, Pakhomov AG, Pakhomova ON. | 09/6/2023 |
| Meta-data analysis of kidney stone disease highlights ATP1A1 involvement in renal crystal formation. | Meta-data analysis of kidney stone disease highlights ATP1A1 involvement in renal crystal formation.
Li Y, Lu X, Yu Z, Wang H, Gao B., Free PMC Article | 03/20/2023 |
| Na, K-ATPase alpha1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape. | Na, K-ATPase α1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape.
Yang K, Li Z, Chen Y, Yin F, Ji X, Zhou J, Li X, Zeng T, Fei C, Ren C, Wang Y, Fang L, Chen L, Zhang P, Mu L, Qian Y, Chen Y, Yin W., Free PMC Article | 02/23/2023 |
| Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation. | Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.
Chen YI, Chang CC, Hsu MF, Jeng YM, Tien YW, Chang MC, Chang YT, Hu CM, Lee WH., Free PMC Article | 06/11/2022 |
| Insulin alleviates LPS-induced ARDS via inhibiting CUL4B-mediated proteasomal degradation and restoring expression level of Na,K-ATPase alpha1 subunit through elevating HCF-1. | Insulin alleviates LPS-induced ARDS via inhibiting CUL4B-mediated proteasomal degradation and restoring expression level of Na,K-ATPase α1 subunit through elevating HCF-1.
Huang XT, Zheng Y, Long G, Peng WT, Wan QQ. | 05/28/2022 |
| Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma. | Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma.
Nanao Y, Oki K, Kobuke K, Itcho K, Baba R, Kodama T, Otagaki Y, Okada A, Yoshii Y, Nagano G, Ohno H, Arihiro K, Gomez-Sanchez CE, Hattori N, Yoneda M., Free PMC Article | 05/7/2022 |
| De Novo ATP1A1 Variants in an Early-Onset Complex Neurodevelopmental Syndrome. | De Novo ATP1A1 Variants in an Early-Onset Complex Neurodevelopmental Syndrome.
Dohrn MF, Rebelo AP, Srivastava S, Cappuccio G, Smigiel R, Malhotra A, Basel D, van de Laar I, Neuteboom RF, Aarts-Tesselaar C, Mahida S, Brunetti-Pierri N, Taft RJ, Züchner S., Free PMC Article | 04/16/2022 |
| ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation. | ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation.
Kobuke K, Oki K, Gomez-Sanchez CE, Gomez-Sanchez EP, Itcho K, Ohno H, Nagano G, Yoshii Y, Baba R, Kodama T, Arihiro K, Hattori N, Yoneda M., Free PMC Article | 01/1/2022 |
| Diseases caused by mutations in the Na(+)/K(+) pump alpha1 gene ATP1A1. | Diseases caused by mutations in the Na(+)/K(+) pump α1 gene ATP1A1.
Biondo ED, Spontarelli K, Ababioh G, Méndez L, Artigas P., Free PMC Article | 11/22/2021 |
| The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2. | The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P(2) facilitating unconventional secretion of Fibroblast Growth Factor 2.
Legrand C, Saleppico R, Sticht J, Lolicato F, Müller HM, Wegehingel S, Dimou E, Steringer JP, Ewers H, Vattulainen I, Freund C, Nickel W., Free PMC Article | 06/19/2021 |
| DR-region of Na(+)/K(+)-ATPase is a target to ameliorate hepatic insulin resistance in obese diabetic mice. | DR-region of Na(+)/K(+)-ATPase is a target to ameliorate hepatic insulin resistance in obese diabetic mice.
Sun HJ, Cao L, Zhu MY, Wu ZY, Shen CY, Nie XW, Bian JS., Free PMC Article | 05/22/2021 |
| Hereditary spastic paraplegia is a novel phenotype for germline de novo ATP1A1 mutation. | Hereditary spastic paraplegia is a novel phenotype for germline de novo ATP1A1 mutation.
Stregapede F, Travaglini L, Rebelo AP, Cintra VP, Bellacchio E, Bosco L, Alfieri P, Pro S, Zuchner S, Bertini E, Nicita F. | 02/6/2021 |
| Decreased Na(+)/K(+) ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients. | Decreased Na(+)/K(+) ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients.
Hosseinzadeh Z, Hauser S, Singh Y, Pelzl L, Schuster S, Sharma Y, Höflinger P, Zacharopoulou N, Stournaras C, Rathbun DL, Zrenner E, Schöls L, Lang F., Free PMC Article | 01/16/2021 |
| Helicobacter pylori decreases levels of Na-K-ATPase in gastric epithelial cells. The bacteria interfere with BiP-assisted folding of newly-made Na-K-ATPase subunits in the endoplasmic reticulum, accelerating their ubiquitylation and proteasomal degradation and decreasing efficiency of the assembly of native enzyme. | Helicobacter pylori infection impairs chaperone-assisted maturation of Na-K-ATPase in gastric epithelium.
Marcus EA, Tokhtaeva E, Jimenez JL, Wen Y, Naini BV, Heard AN, Kim S, Capri J, Cohn W, Whitelegge JP, Vagin O., Free PMC Article | 08/1/2020 |
| Model results demonstrate that a reduction in the local NCX1- and NaK-mediated regulation of dyadic [Ca(2+)] and [Na(+)] results in an increase in Ca(2+) spark activity during isoproterenol stimulation, which in turn stochastically activates NCX1 in the dyad. | Na(+) microdomains and sparks: Role in cardiac excitation-contraction coupling and arrhythmias in ankyrin-B deficiency.
Chu L, Greenstein JL, Winslow RL. | 06/20/2020 |
| Study identified two novel heterozygous mutations in ATP1A1, p.S207F and p.G877S, in the undefined Charcot-Marie-Tooth (CMT) cohort which were associated with classic intermediate CMT phenotypes. Functional analysis revealed that these mutations led to the loss function of the ATP1A1 protein by promoting its proteasome degradation. Taken together, ATP1A1 is confirmed as a novel causative gene for intermediate CMT. | ATP1A1 mutations cause intermediate Charcot-Marie-Tooth disease.
He J, Guo L, Lin S, Chen W, Xu G, Cai B, Xu L, Hong J, Qiu L, Wang N, Chen W. | 05/9/2020 |
| The observed functional consequences of each hyperaldosteronism mutant point to the loss of Na/K pump function as the common feature of all mutants, which is sufficient to induce hyperaldosteronism. | Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.
Meyer DJ, Gatto C, Artigas P., Free PMC Article | 01/18/2020 |
| the efficiency of alpha-subunit glutathionylation depends on enzyme conformation, which is altered by bound ligands and proteins. | Na,K-ATPase α-subunit conformation determines glutathionylation efficiency.
Poluektov YM, Dergousova EA, Lopina OD, Mitkevich VA, Makarov AA, Petrushanko IY. | 11/30/2019 |
| These findings provide a novel strategy to eradicate HIV-infected macrophages by selectively killing infected cells through the induction of Na(+)/K(+)-ATPase dependent autophagy. | Induction of a Na(+)/K(+)-ATPase-dependent form of autophagy triggers preferential cell death of human immunodeficiency virus type-1-infected macrophages.
Zhang G, Luk BT, Hamidy M, Zhang L, Spector SA., Free PMC Article | 10/12/2019 |
| Whole-exome sequencing and conventional Sanger sequencing identified heterozygous de novo mutations in the catalytic Na(+), K(+)-ATPase alpha1 subunit (ATP1A1). | Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.
Schlingmann KP, Bandulik S, Mammen C, Tarailo-Graovac M, Holm R, Baumann M, König J, Lee JJY, Drögemöller B, Imminger K, Beck BB, Altmüller J, Thiele H, Waldegger S, Van't Hoff W, Kleta R, Warth R, van Karnebeek CDM, Vilsen B, Bockenhauer D, Konrad M., Free PMC Article | 05/18/2019 |
| mutations in ATP1A1, which encodes the alpha1 subunit of the Na(+),K(+)-ATPase, are identified as a cause of autosomal-dominant CMT2. | Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2.
Lassuthova P, Rebelo AP, Ravenscroft G, Lamont PJ, Davis MR, Manganelli F, Feely SM, Bacon C, Brožková DŠ, Haberlova J, Mazanec R, Tao F, Saghira C, Abreu L, Courel S, Powell E, Buglo E, Bis DM, Baxter MF, Ong RW, Marns L, Lee YC, Bai Y, Isom DG, Barro-Soria R, Chung KW, Scherer SS, Larsson HP, Laing NG, Choi BO, Seeman P, Shy ME, Santoro L, Zuchner S., Free PMC Article | 12/22/2018 |