| S-100 and MATH-1 Protein Expressions Can Be Useful for the Prediction of Clinical Outcome in Neuroblastoma Patients. | S-100 and MATH-1 Protein Expressions Can Be Useful for the Prediction of Clinical Outcome in Neuroblastoma Patients.
Sanlav G, Baran B, Kum Özşengezer S, Kizmazoğlu D, Altun Z, Aktaş S, Olgun N. | 01/9/2024 |
| Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells. | Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells.
Zhang YL, Kang M, Wu JC, Xie MY, Xue RY, Tang Q, Yang H, Li LC., Free PMC Article | 04/16/2022 |
| LGR5, HES1 and ATOH1 in Young Rectal Cancer Patients in Egyptian. | LGR5, HES1 and ATOH1 in Young Rectal Cancer Patients in Egyptian.
Morsy H, Gaballah A, Samir M, Nakundi V, Shamseya M, Mahrous H, Ghazal A, Hashish M, Arafat W., Free PMC Article | 12/25/2021 |
| Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1. | Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1.
Brownstein Z, Gulsuner S, Walsh T, Martins FTA, Taiber S, Isakov O, Lee MK, Bordeynik-Cohen M, Birkan M, Chang W, Casadei S, Danial-Farran N, Abu-Rayyan A, Carlson R, Kamal L, Arnthórsson AÖ, Sokolov M, Gilony D, Lipschitz N, Frydman M, Davidov B, Macarov M, Sagi M, Vinkler C, Poran H, Sharony R, Samra N, Zvi N, Baris-Feldman H, Singer A, Handzel O, Hertzano R, Ali-Naffaa D, Ruhrman-Shahar N, Madgar O, Sofrin-Drucker E, Peleg A, Khayat M, Shohat M, Basel-Salmon L, Pras E, Lev D, Wolf M, Steingrimsson E, Shomron N, Kelley MW, Kanaan MN, Allon-Shalev S, King MC, Avraham KB., Free PMC Article | 07/3/2021 |
| Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm. | Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm.
Katsukura N, Watanabe S, Shirasaki T, Hibiya S, Kano Y, Akahoshi K, Tanabe M, Kirimura S, Akashi T, Kitagawa M, Okamoto R, Watanabe M, Tsuchiya K., Free PMC Article | 03/6/2021 |
| this study shows that ATOH1 can be regarded as a lineage-dependent oncogene in Merkel cell carcinoma | MCPyV Large T Antigen-Induced Atonal Homolog 1 Is a Lineage-Dependency Oncogene in Merkel Cell Carcinoma.
Fan K, Gravemeyer J, Ritter C, Rasheed K, Gambichler T, Moens U, Shuda M, Schrama D, Becker JC. | 07/18/2020 |
| The increased expression of ATOH1 mRNA after LKB1 loss from human Ls174t cells did not involve Notch or Wnt signaling. Knockdown of PDK4 reduced the up-regulation of ATOH1 mRNA after LKB1 knockdown in Ls174t cells. Cells with LKB1 knockdown had a reduced rate of oxygen consumption, which was partially restored by PDK4 inhibition with dichloroacetate, suggesting that LKB1 represses transcription of ATOH1 via PDK4. | LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.
Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Päivinen P, Domènech-Moreno E, Andersson S, Wong IPL, Clevers H, Katajisto P, Mäkelä TP. | 07/11/2020 |
| Atoh1 promotes ciliogenesis by transcriptionally regulating Cep131, which facilitates centriolar satellite clustering to the basal body | Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O. | 08/3/2019 |
| ATOH1 role in colon cancer.Positive ATOH1 expression in colon cancer tissues was significantly associated with lower grade and better overall survival.ATOH1 was the target mRNA of miR-613. | MicroRNA-613 promotes colon cancer cell proliferation, invasion and migration by targeting ATOH1.
Yang X, Zhang L, Song X, He W, Zhang D, Lu Q, Wu J, Wu C, Jiang J. | 06/1/2019 |
| Data indicate that transcription factor atonal bHLH transcription factor 1 protein (Atoh1) is critical for hair cell development and regeneration [Review]. | Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay.
Zhong C, Fu Y, Pan W, Yu J, Wang J. | 04/20/2019 |
| Our results suggest that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and expression of Hes1 and Hath1. | Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Park JH, Lee JM, Lee EJ, Kim DJ, Hwang WB. | 08/25/2018 |
| The authors discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human Sonic Hedgehog-type medulloblastoma. | Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
Klisch TJ, Vainshtein A, Patel AJ, Zoghbi HY., Free PMC Article | 07/14/2018 |
| ATOH1 expression was detected consistently in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis. | ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas.
Grausam KB, Dooyema SDR, Bihannic L, Premathilake H, Morrissy AS, Forget A, Schaefer AM, Gundelach JH, Macura S, Maher DM, Wang X, Heglin AH, Ge X, Zeng E, Puget S, Chandrasekar I, Surendran K, Bram RJ, Schüller U, Talyor MD, Ayrault O, Zhao H., Free PMC Article | 09/30/2017 |
| These data indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is necessary for hair cell fate determination and survival. | Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.
Cheng YF, Tong M, Edge AS., Free PMC Article | 05/20/2017 |
| ATOH1 is increased in advanced Merkel cell carcinoma (MCC) indicating that ATOH1 is involved in MCC progression. | Prognostic relevance of high atonal homolog-1 expression in Merkel cell carcinoma.
Gambichler T, Mohtezebsade S, Wieland U, Silling S, Höh AK, Dreißigacker M, Schaller J, Schulze HJ, Oellig F, Kreuter A, Stockfleth E, Stücker M, Bechara FG, Becker JC. | 02/18/2017 |
| Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1. | Sox2 in the differentiation of cochlear progenitor cells.
Kempfle JS, Turban JL, Edge AS., Free PMC Article | 01/28/2017 |
| mutation not found in group of children with sensorineural hearing loss | The role of transcription factors of neurosensory cells in non-syndromic sensorineural hearing loss with or without inner ear malformation.
Zhou Y, Qing J, Dong Y, Nie J, Li J, Wang C, Liu Y, Peng T, Duan M, Liu X, Xie D. | 12/17/2016 |
| Downregulation of Hath1 expression promoted the proliferation and reduced the apoptosis of KUMA5 squamous cell carcinoma cells. | Effect of Hath1 on the proliferation and apoptosis of cutaneous squamous cell carcinoma in vitro.
Ying Z, Li X, Dang H, Wang F, Xu X., Free PMC Article | 09/10/2016 |
| ATOH1 can induce the differentiation of gastric cancer stem cells. | ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells.
Han ME, Baek SJ, Kim SY, Kang CD, Oh SO., Free PMC Article | 05/7/2016 |
| ATOH1 acts in concert with other transcription factors to directly regulate the cochlear hair cell phenotype. | Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells.
Ikeda R, Pak K, Chavez E, Ryan AF., Free PMC Article | 03/19/2016 |
| Testosterone-bovine serum albumin and Math1 treatment could promote an increase in hair-cell like cells in the lesser epithelial ridge through proliferation and transdifferentiation. | Role of the planar cell polarity pathway in regulating ectopic hair cell-like cells induced by Math1 and testosterone treatment.
Yang XY, Jin K, Ma R, Yang JM, Luo WW, Han Z, Cong N, Ren DD, Chi FL. | 03/5/2016 |
| Atoh1 epigenetic regulation guides hair cell development in the mammalian cochlea | Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea.
Stojanova ZP, Kwan T, Segil N., Free PMC Article | 02/20/2016 |
| Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer | Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
Fukushima K, Tsuchiya K, Kano Y, Horita N, Hibiya S, Hayashi R, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Oshima S, Nagaishi T, Okamoto R, Nakamura T, Watanabe M., Free PMC Article | 10/31/2015 |
| Chicken Atoh1 might have intrinsic functional differences to mammalian Atoh1. | Molecular cloning and functional characterisation of chicken Atonal homologue 1: a comparison with human Atoh1.
Mulvaney JF, Amemiya Y, Freeman SD, Ladher RK, Dabdoub A. | 10/3/2015 |
| In this review, expression of the Atoh1 gene in supporting cells, results in their transformation into immature hair cells. | Atoh1 gene therapy in the cochlea for hair cell regeneration.
Richardson RT, Atkinson PJ. | 08/22/2015 |