| NASP gene contributes to autism by epigenetic dysregulation of neural and immune pathways. | NASP gene contributes to autism by epigenetic dysregulation of neural and immune pathways.
Zhang S, Yang J, Ji D, Meng X, Zhu C, Zheng G, Glessner J, Qu HQ, Cui Y, Liu Y, Wang W, Li X, Zhang H, Xiu Z, Sun Y, Sun L, Li J, Hakonarson H, Li J, Xia Q. | 07/2/2024 |
| Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis. | Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.
Qiu Y, Pei D, Wang M, Wang Q, Duan W, Wang L, Liu K, Guo Y, Luo L, Guo Z, Guan F, Wang Z, Xing A, Liu Z, Ma Z, Jiang G, Yan D, Liu X, Zhang Z, Wang W., Free PMC Article | 04/29/2024 |
| Home Dust Mites Promote MUC5AC Hyper-Expression by Modulating the sNASP/TRAF6 Axis in the Airway Epithelium. | Home Dust Mites Promote MUC5AC Hyper-Expression by Modulating the sNASP/TRAF6 Axis in the Airway Epithelium.
Chen MZ, Wang SA, Hsu SC, Silva KAS, Yang FM., Free PMC Article | 09/3/2022 |
| Knockdown of long noncoding RNA colorectal neoplasia differentially expressed inhibits hepatocellular carcinoma progression by mediating the expression of nuclear autoantigenic sperm protein. | Knockdown of long noncoding RNA colorectal neoplasia differentially expressed inhibits hepatocellular carcinoma progression by mediating the expression of nuclear autoantigenic sperm protein.
Zhu Y, Li B, Xu G, Han C, Xing G., Free PMC Article | 01/22/2022 |
| UBR7 acts as a histone chaperone for post-nucleosomal histone H3. | UBR7 acts as a histone chaperone for post-nucleosomal histone H3.
Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzińska E, Lee AS, Bailey AO, Gaynes MN, Huang J, Bodner J, Rosencrance CD, Wong KA, Morgan MA, Eagen KP, Shilatifard A, Foltz DR., Free PMC Article | 12/25/2021 |
| miR-381-3p targeted and suppressed NASP gene, reduced the viability, migration, invasion, EMT of HNSCC cells, demonstrating that miR-381-3p has the potential to be a therapeutic target in inhibiting the progression of HNSCC | MiR-381-3p suppresses biological characteristics of cancer in head-neck squamous cell carcinoma cells by targeting nuclear autoantigenic sperm protein (NASP).
Kong F, Li L, Wang C, Zhang Q, He S. | 04/4/2020 |
| Results found that NASP expression levels were upregulated in liver tumors. Its down-regulation inhibited liver cells from forming tumors. Also, NASP depletion led to a global decrease of histone H3K9me1 modification associated with newly H3 processing, which occurred directly at the promoters of up-regulated anti-tumor genes BACH2 and RunX1T1. | NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma.
Kang X, Feng Y, Gan Z, Zeng S, Guo X, Chen X, Zhang Y, Wang C, Liu K, Chen X, Jiang X, Song S, Li Y, Chen S, Sun F, Mao Z, Yang X, Chang J. | 05/25/2019 |
| NASP is targeted by miR-29c in gastric cancer cells. miR-29c can decrease NASP expression and the effects observed following miR-29c overexpression are partially due to NASP depletion. | microRNA-29c inhibits cell proliferation by targeting NASP in human gastric cancer.
Yu B, Chen X, Li J, Gu Q, Zhu Z, Li C, Su L, Liu B., Free PMC Article | 03/31/2018 |
| findings reveal a new mode of interaction between a TPR repeat domain of histone chaperone sNASP and an evolutionarily conserved peptide motif found in canonical H3 and in all histone H3 variants | The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats.
Bowman A, Lercher L, Singh HR, Zinne D, Timinszky G, Carlomagno T, Ladurner AG., Free PMC Article | 09/24/2016 |
| Our research demonstrates that knockdown of tNASP effectively inhibits the proliferation and causes G1 phase arrest through ERK/MAPK signal pathway. | Downregulation of tNASP inhibits proliferation through regulating cell cycle-related proteins and inactive ERK/MAPK signal pathway in renal cell carcinoma cells.
Fang J, Wang H, Xi W, Cheng G, Wang S, Su S, Zhang S, Deng Y, Song Z, Xu A, Liu B, Cao J, Wang Z. | 10/31/2015 |
| These results provide evidence that tNASP is ubiquitously produced in various types of human tissues and promotes in vitro nucleosome assembly with H3 variant specificity. | Human tNASP promotes in vitro nucleosome assembly with histone H3.3.
Kato D, Osakabe A, Tachiwana H, Tanaka H, Kurumizaka H. | 04/11/2015 |
| NASP family Proteins are highly conserved throughout the eukaryotes and posses four TPR motifs. It was likely present in the last common ancestor of eukaryotes possibly representing an important innovation regarding H3/H4 transport mechanism. Different TPR motifs in NASP have evolved at different rates with TPR1/4 evolving faster than TPR2/3. | Molecular evolution of NASP and conserved histone H3/H4 transport pathway.
Nabeel-Shah S, Ashraf K, Pearlman RE, Fillingham J., Free PMC Article | 07/7/2014 |
| Studies indicate that histone chalerones nucleoplasmin (NPM2/NPM3) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families. | Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.
Finn RM, Ellard K, Eirín-López JM, Ausió J. | 04/13/2013 |
| an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development. | MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
Ma W, Xie S, Ni M, Huang X, Hu S, Liu Q, Liu A, Zhang J, Zhang Y., Free PMC Article | 05/19/2012 |
| sNASP interacts with linker and core histones through distinct structural domains. | The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms.
Wang H, Ge Z, Walsh ST, Parthun MR., Free PMC Article | 03/17/2012 |
| The insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand. | A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.
Cook AJ, Gurard-Levin ZA, Vassias I, Almouzni G. | 02/25/2012 |
| tNASP is critical for the survival of prostate cancer cells; targeting tNASP expression can lead to a new approach for prostate cancer treatment. | Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells.
Alekseev OM, Richardson RT, Tsuruta JK, O'Rand MG., Free PMC Article | 10/15/2011 |
| NASP and RCAS1 proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 was less frequently expressed | Analysis of the expression of human tumor antigens in ovarian cancer tissues.
Ali-Fehmi R, Chatterjee M, Ionan A, Levin NK, Arabi H, Bandyopadhyay S, Shah JP, Bryant CS, Hewitt SM, O'Rand MG, Alekseev OM, Morris R, Munkarah A, Abrams J, Tainsky MA., Free PMC Article | 05/31/2010 |
| A deletion analysis of sNASP revealed that the central region, amino acid residues 26-325, of sNASP is responsible for nucleosome assembly in vitro. | Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP).
Osakabe A, Tachiwana H, Matsunaga T, Shiga T, Nozawa RS, Obuse C, Kurumizaka H., Free PMC Article | 05/10/2010 |
| NASP belongs to a network of genes and gene functions that are critical for cell survival | Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP.
Alekseev OM, Richardson RT, Alekseev O, O'Rand MG., Free PMC Article | 01/21/2010 |
| NASP forms distinct, high specificity complexes with histones H3 and H4. | Expanded binding specificity of the human histone chaperone NASP.
Wang H, Walsh ST, Parthun MR., Free PMC Article | 01/21/2010 |
| NASP and the linker histones are key players in the assembly of chromatin after DNA replication | Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation.
Richardson RT, Alekseev OM, Grossman G, Widgren EE, Thresher R, Wagner EJ, Sullivan KD, Marzluff WF, O'Rand MG. | 01/21/2010 |