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    NAP1L1 nucleosome assembly protein 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 4673, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility.

    Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility.
    Gul G, Aydin MA, Algul S, Kiziltan R, Kemik O.

    02/23/2024
    Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One and Two Histone H2A-H2B Heterodimers Obtained by Integrative Methods.

    Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One and Two Histone H2A-H2B Heterodimers Obtained by Integrative Methods.
    Ohtomo H, Yamane T, Oda T, Kodera N, Kurita JI, Tsunaka Y, Amyot R, Ikeguchi M, Nishimura Y.

    07/21/2023
    A New Role of NAP1L1 in Megakaryocytes and Human Platelets.

    A New Role of NAP1L1 in Megakaryocytes and Human Platelets.
    Freitag M, Schwertz H., Free PMC Article

    12/31/2022
    NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.

    NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.
    Xiaohua Zhu, Xie Y, Huang W, Chen Z, Guo S., Free PMC Article

    04/9/2022
    NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma.

    NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma.
    Liu Y, Li X, Zhang Y, Tang Y, Fang W, Liu X, Liu Z.

    01/29/2022
    Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma.

    Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma.
    Nagashio R, Kuchitsu Y, Igawa S, Kusuhara S, Naoki K, Satoh Y, Ichinoe M, Murakumo Y, Saegusa M, Sato Y.

    05/15/2021
    The NAP1L1 regulates cell fate by controlling the expression of p53-responsive proarrest and proapoptotic genes through selective modulation of p53 acetylation at specific sites during normal homeostasis and in stress-induced responses.

    Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate.
    Tanaka T, Hozumi Y, Martelli AM, Iino M, Goto K.

    03/21/2020
    Through regulating NAP1L1, PRDM8 inhibits PI3K/AKT/mTOR signaling in hepatocellular carcinoma.

    PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1.
    Chen Z, Gao W, Pu L, Zhang L, Han G, Zuo X, Zhang Y, Li X, Shen H, Wu J, Wang X.

    12/28/2019
    Long non-coding RNAs (lncRNAs) CDKN2B-AS1 promoted nucleosome assembly protein 1 like 1 (NAP1L1) expression by sponging let-7c-5p in hepatocellular carcinoma (HCC) cells.

    LncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis.
    Huang Y, Xiang B, Liu Y, Wang Y, Kan H.

    09/28/2019
    Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

    Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.
    Machida S, Takaku M, Ikura M, Sun J, Suzuki H, Kobayashi W, Kinomura A, Osakabe A, Tachiwana H, Horikoshi Y, Fukuto A, Matsuda R, Ura K, Tashiro S, Ikura T, Kurumizaka H., Free PMC Article

    04/22/2019
    evaluated the currently known TBK1-mediated phosphorylation sites in the SKICH domains of NDP52 and TAX1BP1 on the basis of their interactions with NAP1

    Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
    Fu T, Liu J, Wang Y, Xie X, Hu S, Pan L., Free PMC Article

    02/9/2019
    In summary, the authors identified NAP1L1 as a novel binding partner of hepatitis c virus NS3 and found that the protease domain of NS3 is responsible for interactions with NAP1L1. They demonstrated the functional role of NAP1L1 in hepatitis c virus entry through regulating the protein expression of SR-B1.

    NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3.
    Yin P, Li Y, Zhou L, Zhang L., Free PMC Article

    10/6/2018
    knockdown of NAP1L1 suppresses IkappaBalpha degradation and nuclear transport of p65 subunit after treatment with TNF-a stimulation, leading to attenuation of the NF-kappaB transcriptional activity, whereas NAP1L4 knockdown remains silent.results of this study suggest that NAP1L1 downregulation renders the cell vulnerable to apoptotic cell death through attenuation of NF-kappaB transcriptional activity on the anti-apop...

    NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression.
    Tanaka T, Hozumi Y, Iino M, Goto K.

    12/9/2017
    NAP1L1 increases CSB processivity by decreasing the pausing probability during translocation. Our study, therefore, uncovers the different steps of CSB-mediated chromatin remodeling that can be regulated by NAP1L1.

    NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB.
    Lee JY, Lake RJ, Kirk J, Bohr VA, Fan HY, Hohng S., Free PMC Article

    09/16/2017
    Here the authors confirmed the hepatitis C virus NS5A-NAP1L1 interaction and mapped it to the C terminus of NS5A of both hepatitis C virus genotype 1 and 2.

    Hepatitis C Virus NS5A Targets Nucleosome Assembly Protein NAP1L1 To Control the Innate Cellular Response.
    Çevik RE, Cesarec M, Da Silva Filipe A, Licastro D, McLauchlan J, Marcello A., Free PMC Article

    09/2/2017
    TAF-Ibeta promotes BZLF1 expression and subsequent lytic infection by affecting chromatin at the BZLF1 promoter

    A role for the nucleosome assembly proteins TAF-Iβ and NAP1 in the activation of BZLF1 expression and Epstein-Barr virus reactivation.
    Mansouri S, Wang S, Frappier L., Free PMC Article

    01/4/2014
    NAP1L1 was down-expressed following antiproliferative agent treatment in AuL12-treated cells in comparison with control and with Au(2)Phen-treated ovarian cancer cells.

    2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compounds.
    Guidi F, Puglia M, Gabbiani C, Landini I, Gamberi T, Fregona D, Cinellu MA, Nobili S, Mini E, Bini L, Modesti PA, Modesti A, Messori L.

    06/30/2012
    Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.

    Interaction between nucleosome assembly protein 1-like family members.
    Attia M, Förster A, Rachez C, Freemont P, Avner P, Rogner UC.

    06/4/2011
    The biochemical properties of two human NAP1-like proteins, hNAP1L1 and hNAP1L4, were characterized.

    Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones.
    Okuwaki M, Kato K, Nagata K.

    05/31/2010
    These results suggest that the binding of sequence-specific DNA binding proteins to human nucleosome assembly protein 1 may be an important step contributing to the activation of transcription.

    Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription.
    Rehtanz M, Schmidt HM, Warthorst U, Steger G., Free PMC Article

    01/21/2010
    Data show that Alien binds in vivo and in vitro to NAP1 and modulates its activity by enhancing NAP1-mediated nucleosome assembly on DNA.

    The nucleosome assembly activity of NAP1 is enhanced by Alien.
    Eckey M, Hong W, Papaioannou M, Baniahmad A., Free PMC Article

    01/21/2010
    both the acidic nature of nucleosome assembly protein I and its other functional structure(s) may be essential to mediate the assembly and disassembly of the dimers in nucleosome core particles

    Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.
    Okuwaki M, Kato K, Shimahara H, Tate S, Nagata K., Free PMC Article

    01/21/2010
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