| Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC. | Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC.
Li C, Guan R, Li W, Wei D, Cao S, Chang F, Wei Q, Wei R, Chen L, Xu C, Wu K, Lei D., Free PMC Article | 09/13/2023 |
| MYBPC2 and MYL1 as Significant Gene Markers for Rhabdomyosarcoma. | MYBPC2 and MYL1 as Significant Gene Markers for Rhabdomyosarcoma.
Chen Z, Li XY, Guo P, Wang DL., Free PMC Article | 11/22/2021 |
| MYL2 as a potential predictive biomarker for rhabdomyosarcoma. | MYL2 as a potential predictive biomarker for rhabdomyosarcoma.
Wang J, Gao S, Dong K, Guo P, Shan MJ., Free PMC Article | 10/30/2021 |
| Our data implicate MYL1 as a crucial protein for adequate skeletal muscle function and that MYL1 deficiency is associated with severe congenital myopathy. | Bi-allelic mutations in MYL1 cause a severe congenital myopathy.
Ravenscroft G, Zaharieva IT, Bortolotti CA, Lambrughi M, Pignataro M, Borsari M, Sewry CA, Phadke R, Haliloglu G, Ong R, Goullée H, Whyte T, Consortium UK, Manzur A, Talim B, Kaya U, Osborn DPS, Forrest ARR, Laing NG, Muntoni F., Free PMC Article | 05/11/2019 |
| MLCK and phosphorylated MLC are potential prognostic indicators of leiomyosarcoma. | Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
Li HS, Lin Q, Wu J, Jiang ZH, Zhao JB, Pan J, He WQ, Zha JM. | 04/7/2018 |
| these results provide new insights into the sequences and modifications of myosin light chain isoforms in the human and swine hearts, which will pave the way for a better understanding of their functional roles in cardiac physiology and pathophysiology. | Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.
Gregorich ZR, Cai W, Lin Z, Chen AJ, Peng Y, Kohmoto T, Ge Y., Free PMC Article | 03/10/2018 |
| These results support the concept of the ATP-induced transient interaction of the essential light chain-1 N-terminus with the motor domain of the myosin head. | Transient interaction between the N-terminal extension of the essential light chain-1 and motor domain of the myosin head during the ATPase cycle.
Logvinova DS, Matyushenko AM, Nikolaeva OP, Levitsky DI. | 01/6/2018 |
| polymorphism of intron MYL1 was associated with endurance performance, specifically in endurance trainability, but not genetic predisposition, in human adults. | Intron polymorphism in MYL1 gene is associated with individual cardiac trainability to endurance training in human myocardium.
Lin X, Wang D, Wen L, Zhou S, Hu Y, Zhang Y. | 04/15/2017 |
| This study provides an additional mechanistic link between Angiotensin II and vasoconstriction via SFK-enhanced MLC phosphorylation in smooth muscle cells. | Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension.
Qin B, Zhou J., Free PMC Article | 04/23/2016 |
| MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 | The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.
Korkina O, Dong Z, Marullo A, Warshaw G, Symons M, Ruggieri R., Free PMC Article | 04/27/2013 |
| Disturbed myosin binding of mutated hVLC-1 may provide a pathomechanism for the development of hypertrohic cardiomyopathy. | Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.
Lossie J, Ushakov DS, Ferenczi MA, Werner S, Keller S, Haase H, Morano I. | 06/16/2012 |
| In vitro degradation of human recombinant MLC1 by MMP-2 increased after ONOO(-) exposure of MLC1 in a concentration-dependent manner | Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.
Polewicz D, Cadete VJ, Doroszko A, Hunter BE, Sawicka J, Szczesna-Cordary D, Light PE, Sawicki G., Free PMC Article | 12/10/2011 |
| Influenza infection activates a series of signaling pathways that converge to induce myosin light chain (MLC) phosphorylation and remodeling of the actin cytoskeleton. | Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents.
Haidari M, Zhang W, Ganjehei L, Ali M, Chen Z., Free PMC Article | 11/5/2011 |