| A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB. | A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.
Bayer A, Child SJ, Malik HS, Geballe AP., Free PMC Article | 02/7/2024 |
| Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients. | Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
He M, Liu M, Geng J, Liu L, Huang P, Yue M, Xia X, Zhang AM., Free PMC Article | 02/9/2023 |
| Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China. | Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
Zheng K, Shen Y, Xia X, Song Y, Zhang AM., Free PMC Article | 01/14/2023 |
| MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus. | MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.
Meng XW, Cheng ZL, Lu ZY, Tan YN, Jia XY, Zhang M., Free PMC Article | 09/17/2022 |
| The transcriptome profile of human trisomy 21 blood cells. | The transcriptome profile of human trisomy 21 blood cells.
Antonaros F, Zenatelli R, Guerri G, Bertelli M, Locatelli C, Vione B, Catapano F, Gori A, Vitale L, Pelleri MC, Ramacieri G, Cocchi G, Strippoli P, Caracausi M, Piovesan A., Free PMC Article | 02/5/2022 |
| High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells. | High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells.
Ren Y, Chen M, Wu G, Ji D, Zhou GG, Ren PG, Fu W., Free PMC Article | 01/29/2022 |
| Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication. | Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.
Wang YX, Niklasch M, Liu T, Wang Y, Shi B, Yuan W, Baumert TF, Yuan Z, Tong S, Nassal M, Wen YM. | 10/9/2021 |
| MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation. | MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.
Betancor G, Jimenez-Guardeño JM, Lynham S, Antrobus R, Khan H, Sobala A, Dicks MDJ, Malim MH., Free PMC Article | 09/18/2021 |
| MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy. | MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.
Juraleviciute M, Nsengimana J, Newton-Bishop J, Hendriks GJ, Slipicevic A., Free PMC Article | 07/24/2021 |
| MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6. | MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6.
Xie L, Chen L, Zhong C, Yu T, Ju Z, Wang M, Xiong H, Zeng Y, Wang J, Hu H, Hou W, Feng Y., Free PMC Article | 06/26/2021 |
| HIV-1 resists MxB inhibition of viral Rev protein. | HIV-1 resists MxB inhibition of viral Rev protein.
Wang Z, Chai K, Liu Q, Yi DR, Pan Q, Huang Y, Tan J, Qiao W, Guo F, Cen S, Liang C., Free PMC Article | 04/24/2021 |
| MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface. | MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface.
Miles RJ, Kerridge C, Hilditch L, Monit C, Jacques DA, Towers GJ., Free PMC Article | 02/20/2021 |
| MX 2 is a novel regulator of cell cycle in melanoma cells. | MX 2 is a novel regulator of cell cycle in melanoma cells.
Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Øy GF, Trøen G, Flørenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A., Free PMC Article | 02/6/2021 |
| Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid. | Pro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid.
Xu F, Zhao F, Zhao X, Zhang D, Liu X, Hu S, Mei S, Fan Z, Huang Y, Sun H, Wei L, Wu C, Li Q, Wang J, Cen S, Liang C, Guo F., Free PMC Article | 12/26/2020 |
| Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-kappaB pathway in glioblastoma cells. | Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF-κB pathway in glioblastoma cells.
Wang H, Guan Q, Nan Y, Ma Q, Zhong Y. | 10/3/2020 |
| The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction. | The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction.
Betancor G, Dicks MDJ, Jimenez-Guardeño JM, Ali NH, Apolonia L, Malim MH., Free PMC Article | 09/19/2020 |
| Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. | Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.
Choi J, Zhang T, Vu A, Ablain J, Makowski MM, Colli LM, Xu M, Hennessey RC, Yin J, Rothschild H, Gräwe C, Kovacs MA, Funderburk KM, Brossard M, Taylor J, Pasaniuc B, Chari R, Chanock SJ, Hoggart CJ, Demenais F, Barrett JH, Law MH, Iles MM, Yu K, Vermeulen M, Zon LI, Brown KM., Free PMC Article | 08/22/2020 |
| Study shows that MxB is targeting the HIV capsid by recognizing the region created at the intersection of three CA hexamers, and allos to map this interaction to a few CA residues, located in a negatively charged well at the interface between the three CA hexamers. | MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid.
Smaga SS, Xu C, Summers BJ, Digianantonio KM, Perilla JR, Xiong Y., Free PMC Article | 05/9/2020 |
| MxB is an inner mitochondrial membrane GTPase that plays an important role in the maintenance of mitochondrial cristae and DNA stability of this organelle. | The anti-viral dynamin family member MxB participates in mitochondrial integrity.
Cao H, Krueger EW, Chen J, Drizyte-Miller K, Schulz ME, McNiven MA., Free PMC Article | 05/2/2020 |
| SAMHD1 restriction of HIV-1 was found to be defective in non-dividing cells that did not express MxB. | The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB.
Buffone C, Kutzner J, Opp S, Martinez-Lopez A, Selyutina A, Coggings SA, Studdard LR, Ding L, Kim B, Spearman P, Schaller T, Diaz-Griffero F., Free PMC Article | 10/26/2019 |
| Authors propose a model whereby multiple components of the nuclear import machinery and nuclear pore complex help position MX2 at the nuclear envelope to promote MX2-mediated restriction of HIV-1. | Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction.
Dicks MDJ, Betancor G, Jimenez-Guardeño JM, Pessel-Vivares L, Apolonia L, Goujon C, Malim MH., Free PMC Article | 02/16/2019 |
| Here, the authors show that HIV-1 capsid can bind multiple nucleoporins that impacts HIV-1 infection in a manner that is strikingly dependent on cell-type, cell-cycle, and cyclophilin A (CypA). They also show that nucleoporins mediate the function of the antiviral protein MX2, and that MX2 can variably inhibit non-viral nuclear localization signal function. | Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD., Free PMC Article | 02/9/2019 |
| Study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. | MxB is an interferon-induced restriction factor of human herpesviruses.
Crameri M, Bauer M, Caduff N, Walker R, Steiner F, Franzoso FD, Gujer C, Boucke K, Kucera T, Zbinden A, Münz C, Fraefel C, Greber UF, Pavlovic J., Free PMC Article | 12/22/2018 |
| These data demonstrate that human MXB but not other human or murine MX proteins inhibit murine cytomegalovirus propagation. Evidently, the viral protein expression was delayed and the viral DNA amount in nucleus was diminished in MXB expressing cells indicating an obstruction of nuclear entry. | MXB inhibits murine cytomegalovirus.
Jaguva Vasudevan AA, Bähr A, Grothmann R, Singer A, Häussinger D, Zimmermann A, Münk C. | 09/1/2018 |
| Therefore, these results demonstrate the importance of MxB in alpha interferon-mediated inhibition of HIV-1 infection. | Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection.
Xu B, Pan Q, Liang C., Free PMC Article | 09/1/2018 |