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    MX1 MX dynamin like GTPase 1 [ Homo sapiens (human) ]

    Gene ID: 4599, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.

    Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
    Sehgal PB, Yuan H, Centone A, DiSenso-Browne SV., Free PMC Article

    04/23/2024
    Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.

    Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
    Xing C, Trivedi J, Bitencourt N, Burns DK, Reisch JS, Cai C.

    04/11/2024
    Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.

    Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
    Zhang F, Zhou P, Wang L, Liao X, Liu X, Ke C, Wen S, Shu Y., Free PMC Article

    03/14/2024
    Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.

    Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
    Honda H, Yagita K, Arahata H, Hamasaki H, Noguchi H, Koyama S, Sasagasako N., Free PMC Article

    03/4/2024
    Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.

    Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
    Chang M, Min Y-Q, Xu Z, Deng F, Wang H, Ning Y-J., Free PMC Article

    01/30/2024
    Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.

    Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
    Allen PC, Roberts K, Rubio JE, Tiwari HK, Absher DM, Cooper SJ, Myers RM, Brown EE., Free PMC Article

    09/8/2023
    Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.

    Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
    Alalem M, Dabous E, Awad AM, Alalem N, Guirgis AA, El-Masry S, Khalil H., Free PMC Article

    08/28/2023
    An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.

    An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
    McKellar J, Arnaud-Arnould M, Chaloin L, Tauziet M, Arpin-André C, Pourcelot O, Blaise M, Moncorgé O, Goujon C., Free PMC Article

    03/10/2023
    Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.

    Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
    He M, Liu M, Geng J, Liu L, Huang P, Yue M, Xia X, Zhang AM., Free PMC Article

    02/9/2023
    Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.

    Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
    Zheng K, Shen Y, Xia X, Song Y, Zhang AM., Free PMC Article

    01/14/2023
    Evaluation of MX1 Gene Promoter Methylation in Different Severities of COVID-19 Considering Patient Gender.

    Evaluation of MX1 Gene Promoter Methylation in Different Severities of COVID-19 Considering Patient Gender.
    Ghoreshi ZA, Abbasi-Jorjandi M, Asadikaram G, Sharifzak M, Rezazadeh-Jabalbarzi M, Rashidinejad H.

    10/22/2022
    Myxovirus Resistance Protein A as a Marker of Viral Cause of Illness in Children Hospitalized with an Acute Infection.

    Myxovirus Resistance Protein A as a Marker of Viral Cause of Illness in Children Hospitalized with an Acute Infection.
    Piri R, Yahya M, Ivaska L, Toivonen L, Lempainen J, Nuolivirta K, Tripathi L, Waris M, Peltola V., Free PMC Article

    05/21/2022
    The transcriptome profile of human trisomy 21 blood cells.

    The transcriptome profile of human trisomy 21 blood cells.
    Antonaros F, Zenatelli R, Guerri G, Bertelli M, Locatelli C, Vione B, Catapano F, Gori A, Vitale L, Pelleri MC, Ramacieri G, Cocchi G, Strippoli P, Caracausi M, Piovesan A., Free PMC Article

    02/5/2022
    Myxovirus resistance protein 1-expressing fatal myocarditis in a patient with anti-MDA5 antibody-positive dermatomyositis.

    Myxovirus resistance protein 1-expressing fatal myocarditis in a patient with anti-MDA5 antibody-positive dermatomyositis.
    Sakamoto R, Kotobuki Y, Iga S, Nojima S, Deno R, Hanaoka Y, Tonomura K, Kiyohara E, Nakagawa Y, Ueda-Hayakawa I, Arase N, Fujimoto M.

    01/8/2022
    TLR Stimulation Produces IFN-beta as the Primary Driver of IFN Signaling in Nonlymphoid Primary Human Cells.

    TLR Stimulation Produces IFN-β as the Primary Driver of IFN Signaling in Nonlymphoid Primary Human Cells.
    Nistler R, Sharma A, Meeth K, Huard C, Loreth C, Kalbasi A, Tyminski E, Bellmore R, Coyle AJ, Gullà SV, Berasi SP, Greenberg SA, Buhlmann JE.

    10/16/2021
    Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus.

    Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus.
    Chen Y, Graf L, Chen T, Liao Q, Bai T, Petric PP, Zhu W, Yang L, Dong J, Lu J, Chen Y, Shen J, Haller O, Staeheli P, Kochs G, Wang D, Schwemmle M, Shu Y.

    08/28/2021
    Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.

    Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
    López EL, Ferolla FM, Toledano A, Yfran EW, Giordano AC, Carrizo B, Feldman F, Talarico LB, Caratozzolo A, Contrini MM, Acosta PL, GUTI Respiratory Infections Network.

    06/19/2021
    Myxovirus Resistance Protein 1 (MX1), a Novel HO-1 Interactor, Tilts the Balance of Endoplasmic Reticulum Stress towards Pro-Death Events in Prostate Cancer.

    Myxovirus Resistance Protein 1 (MX1), a Novel HO-1 Interactor, Tilts the Balance of Endoplasmic Reticulum Stress towards Pro-Death Events in Prostate Cancer.
    Ortiz E, Sanchis P, Bizzotto J, Lage-Vickers S, Labanca E, Navone N, Cotignola J, Vazquez E, Gueron G., Free PMC Article

    04/24/2021
    Intrahepatic immune changes after hepatitis c virus eradication by direct-acting antiviral therapy.

    Intrahepatic immune changes after hepatitis c virus eradication by direct-acting antiviral therapy.
    Amaddeo G, Nguyen CT, Maillé P, Mulé S, Luciani A, Machou C, Rodrigues A, Regnault H, Mallat A, Laurent A, Lafdil F, Hézode C, Pawlotsky JM, Calderaro J.

    03/27/2021
    A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.

    A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
    Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B., Free PMC Article

    03/13/2021
    Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer.

    Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer.
    Aljohani AI, Joseph C, Kurozumi S, Mohammed OJ, Miligy IM, Green AR, Rakha EA., Free PMC Article

    01/23/2021
    Subcellular Localization of MxB Determines Its Antiviral Potential against Influenza A Virus.

    Subcellular Localization of MxB Determines Its Antiviral Potential against Influenza A Virus.
    Steiner F, Pavlovic J., Free PMC Article

    01/9/2021
    Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.

    Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.
    Soponkanaporn S, Deakin CT, Schutz PW, Marshall LR, Yasin SA, Johnson CM, Sag E, Tansley SL, McHugh NJ, Wedderburn LR, Jacques TS., Free PMC Article

    08/22/2020
    New data correct a long-standing misinterpretation in the MxA literature and provide evidence for membraneless MxA biomolecular condensates in the uninfected cell cytoplasm.

    Human Antiviral Protein MxA Forms Novel Metastable Membraneless Cytoplasmic Condensates Exhibiting Rapid Reversible Tonicity-Driven Phase Transitions.
    Davis D, Yuan H, Liang FX, Yang YM, Westley J, Petzold C, Dancel-Manning K, Deng Y, Sall J, Sehgal PB., Free PMC Article

    07/25/2020
    Rapidly evolving MxA residues yield super-restrictor antiviral proteins.

    Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.
    Colón-Thillet R, Hsieh E, Graf L, McLaughlin RN Jr, Young JM, Kochs G, Emerman M, Malik HS., Free PMC Article

    02/29/2020
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