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    MUC6 mucin 6, oligomeric mucus/gel-forming [ Homo sapiens (human) ]

    Gene ID: 4588, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors.

    Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors.
    Dwertmann Rico S, Schliesser SJA, Gorbokon N, Dum D, Menz A, Büscheck F, Hinsch A, Lennartz M, von Bargen C, Bawahab AA, Luebke AM, Hube-Magg C, Fraune C, Lebok P, Clauditz TS, Jacobsen F, Sauter G, Uhlig R, Steurer S, Minner S, Marx AH, Simon R, Burandt E, Hoeflmayer D, Krech T, Bernreuther C.

    07/26/2023
    Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).

    Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).
    Buyuk M, Ozluk Y, Bakkaloglu DV, Ozkan B, Firat P, Yilmazbayhan D., Free PMC Article

    01/21/2023
    MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung.

    MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung.
    Yamanoi K, Fujii C, Yuzuriha H, Kumazawa M, Shimoda M, Emoto K, Asamura H, Nakayama J.

    05/28/2022
    Glycosylation of MUC6 by alpha1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.

    Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.
    Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J., Free PMC Article

    02/12/2022
    Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound-guided aspiration/biopsy specimens.

    Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound-guided aspiration/biopsy specimens.
    Wong NACS, Beavers S, Gill P, Heryet A, Linares J.

    02/12/2022
    Diffuse expression of MUC6 defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma.

    Diffuse expression of MUC6 defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma.
    Kishikawa S, Hayashi T, Saito T, Takamochi K, Kohsaka S, Sano K, Sasahara N, Sasa K, Kurihara T, Hara K, Suehara Y, Takahashi F, Suzuki K, Yao T.

    11/22/2021
    Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer.

    Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer.
    Shi D, Xi XX., Free PMC Article

    10/30/2021
    Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.

    Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.
    Oral O, Unverdi H, Kumcu E, Turkbey D, Dogan S, Hucumenoglu S.

    07/24/2021
    Long noncoding RNA CASC2 suppresses pancreatic cancer cell growth and progression by regulating the miR24/MUC6 axis.

    Long non‑coding RNA CASC2 suppresses pancreatic cancer cell growth and progression by regulating the miR‑24/MUC6 axis.
    Xu DF, Wang LS, Zhou JH., Free PMC Article

    10/24/2020
    We found evidence of late-onset Alzheimer disease-associated genetic polymorphism within an exon of Mucin 6 (MUC6) and immediately downstream from another gene: AP2A2

    Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.
    Katsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang WX, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT., Free PMC Article

    07/25/2020
    sequences of these mucins will now allow such studies, which could be of importance for inflammatory bowel diseases for MUC2 and gastric ulcer diseases for MUC6 where deficient mucus protection is assumed to play an important role

    The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals.
    Svensson F, Lang T, Johansson MEV, Hansson GC., Free PMC Article

    12/14/2019
    The gastric phenotype of MUC5AC and MUC6 may be linked to the malignant potential of superficial non-ampullary duodenal epithelial tumors

    Clinicopathological features of superficial non-ampurally duodenal epithelial tumor; gastric phenotype of histology correlates to higher malignant potency.
    Toba T, Inoshita N, Kaise M, Nomura K, Kuribayashi Y, Tanaka M, Yamashita S, Furuhata T, Kikuchi D, Matsui A, Mitani T, Iizuka T, Hoteya S.

    01/19/2019
    The detection of MUC4 and/or MUC6 might be a powerful parameter in the clinical management of mucoepidermoid carcinoma in the early postsurgical phase.

    Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase.
    Honjo K, Hiraki T, Higashi M, Noguchi H, Nomoto M, Yoshimura T, Batra SK, Yonezawa S, Semba I, Nakamura N, Tanimoto A, Yamada S.

    08/18/2018
    The expression of MUC5AC, MUC2, and MUC6 mRNA in CagA-transfected AGS cells at an NH concentration of 15 mM was significantly higher than that at 0 mM, and decreased at higher concentrations. H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not E-cadherin.

    Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.
    Zhang X, Shi D, Liu YP, Chen WJ, Wu D., Free PMC Article

    06/16/2018
    decreased expression of alphaGlcNAc relative to MUC6 occurs early and marks the initiation of tumor progression to pancreatic cancer.

    Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer.
    Ohya A, Yamanoi K, Shimojo H, Fujii C, Nakayama J., Free PMC Article

    10/21/2017
    outcome, while the gain of aberrant expression of MUC5AC and particularly of MUC6 was associated with favorable outcome in colorectal cancer, notably in intermediate stages II and III

    MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.
    Betge J, Schneider NI, Harbaum L, Pollheimer MJ, Lindtner RA, Kornprat P, Ebert MP, Langner C., Free PMC Article

    02/25/2017
    In ovarian mucinous tumors, MUC6 expression changes with the progression of benign to borderline and malignant tumours

    Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours.
    Wang J, El-Bahrawy M.

    11/7/2015
    CDX2, MUC1, MUC5AC, and MUC6 expression patterns may provide better estimations of survival after surgical resection of small intestinal adenocarcinoma.

    Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma.
    Jun SY, Eom DW, Park H, Bae YK, Jang KT, Yu E, Hong SM.

    06/6/2015
    The expression of a subset of mucins (MUC2, MUC6, MUC5B) was also correlated with sialyl-Tn expression in LS174T cells.

    Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.
    Chik JH, Zhou J, Moh ES, Christopherson R, Clarke SJ, Molloy MP, Packer NH.

    04/4/2015
    There was no difference in the expression of deep MUC1, MUC2, MUC5AC, or MUC6 between the groups of gastric cancer and controls.

    Gastric mucin expression in first-degree relatives of gastric cancer patients.
    Boltin D, Gingold-Belfer R, Dickman R, Halpern M, Morgenstern S, Roth M, Layfer O, Vilkin A, Niv Y, Levi Z.

    01/24/2015
    Human TTF2 is a lectin that binds alpha-GlcNAc-capped mucin 6 g with antibiotic activity against Helicobacter pylori.

    Human trefoil factor 2 is a lectin that binds α-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.
    Hanisch FG, Bonar D, Schloerer N, Schroten H., Free PMC Article

    12/20/2014
    High MUC6 expression is associated with gastric carcinoma.

    Mucin phenotype expression of gastric neuroendocrine neoplasms: analysis of histopathology and carcinogenesis.
    Domori K, Nishikura K, Ajioka Y, Aoyagi Y.

    12/20/2014
    we report the expression pattern of MUC2, MUC5AC, MUC5B, and MUC6 in a large series of colorectal carcinomas

    Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.
    Walsh MD, Clendenning M, Williamson E, Pearson SA, Walters RJ, Nagler B, Packenas D, Win AK, Hopper JL, Jenkins MA, Haydon AM, Rosty C, English DR, Giles GG, McGuckin MA, Young JP, Buchanan DD.

    08/16/2014
    Data indicate that MUC1 and MUC4 were differentially glycosylated as the disease progressed, and the expression of MUC6 in acinar cells.

    Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.
    Remmers N, Anderson JM, Linde EM, DiMaio DJ, Lazenby AJ, Wandall HH, Mandel U, Clausen H, Yu F, Hollingsworth MA., Free PMC Article

    11/16/2013
    Secretory carcinomas of breast show a unique pattern of strong MUC2, MUC6, and MUC 4 expression.

    Secretory carcinoma of breast: pattern of MUC 2/MUC 4/MUC 6 expression.
    Shet T, Valsangar S, Dhende S.

    09/21/2013
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