| Bulky hydrophobic side chains in the beta1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids. | Bulky hydrophobic side chains in the β1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids.
Anaganti N, Valmiki S, Recacha R, Islam S, Farber S, Ruddock L, Hussain MM., Free PMC Article | 04/11/2024 |
| Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis. | Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis.
Prata TVG, Paula VG, Passos LO, Brogiato VLB, Ferreira GM, Manchiero C, Dantas BP, Battaglia DBR, Figueiredo GM, Tengan FM, Magri MC. | 03/11/2024 |
| Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. | Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion.
van Zwol W, Rimbert A, Wolters JC, Smit M, Bloks VW, Kloosterhuis NJ, Huijkman NCA, Koster MH, Tharehalli U, de Neck SM, Bournez C, Fuh MM, Kuipers J, Rajan S, de Bruin A, Ginsberg HN, van Westen GJP, Hussain MM, Scheja L, Heeren J, Zimmerman P, van de Sluis B, Kuivenhoven JA., Free PMC Article | 11/13/2023 |
| Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review and meta-analysis. | Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review and meta-analysis.
Wang X, Cao Y, Guo J, Li D, Zhang H, Song Q, Lu J., Free PMC Article | 09/22/2023 |
| Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity. | Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity.
Rajan S, Hofer P, Christiano A, Stevenson M, Ragolia L, Villa-Cuesta E, Fried SK, Lau R, Braithwaite C, Zechner R, Schwartz GJ, Hussain MM. | 12/3/2022 |
| Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis. | Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis.
Prata TVG, Manchiero C, Dantas BP, Nunes AKDS, Tengan FM, Magri MC., Free PMC Article | 09/3/2022 |
| An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein. | An improved assay to measure the phospholipid transfer activity of microsomal triglyceride transport protein.
Anaganti N, Rajan S, Hussain MM., Free PMC Article | 03/26/2022 |
| Normal plasma apoB48 despite the virtual absence of apoB100 in a compound heterozygote with novel mutations in the MTTP gene. | Normal plasma apoB48 despite the virtual absence of apoB100 in a compound heterozygote with novel mutations in the MTTP gene.
Takahashi M, Ozaki N, Nagashima S, Wakabayashi T, Iwamoto S, Ishibashi S. | 03/12/2022 |
| A novel p.Gly417Valfs*12 mutation in the MTTP gene causing abetalipoproteinemia: Presentation of the first patient in Mexico and analysis of the previously reported cases. | A novel p.Gly417Valfs*12 mutation in the MTTP gene causing abetalipoproteinemia: Presentation of the first patient in Mexico and analysis of the previously reported cases.
Rodríguez Gutiérrez PG, González García JR, Castillo De León YA, Zárate Guerrero JR, Magaña Torres MT., Free PMC Article | 11/6/2021 |
| 17beta-Estradiol-Induced Conformational Changes of Human Microsomal Triglyceride Transfer Protein: A Computational Molecular Modelling Study. | 17β-Estradiol-Induced Conformational Changes of Human Microsomal Triglyceride Transfer Protein: A Computational Molecular Modelling Study.
Yang YX, Li P, Wang P, Zhu BT., Free PMC Article | 10/30/2021 |
| Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4. | Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4.
Hemeda AA, Ahmad Mohamed A, Aziz RK, Abdel-Hakeem MS, Ali-Tammam M., Free PMC Article | 08/14/2021 |
| Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids. | Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids.
Iqbal J, Mascareno E, Chua S, Hussain MM., Free PMC Article | 12/12/2020 |
| A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein. | A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein.
Wilson MH, Rajan S, Danoff A, White RJ, Hensley MR, Quinlivan VH, Recacha R, Thierer JH, Tan FJ, Busch-Nentwich EM, Ruddock L, Hussain MM, Farber SA., Free PMC Article | 09/26/2020 |
| MTTP may play an important role for the heart function in conjunction to ischemic events. | Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.
Klevstig M, Arif M, Mannila M, Svedlund S, Mardani I, Ståhlman M, Andersson L, Lindbom M, Miljanovic A, Franco-Cereceda A, Eriksson P, Jeppsson A, Gan LM, Levin M, Mardinoglu A, Ehrenborg E, Borén J. | 07/11/2020 |
| common SNPs and a rare mutation in MTTP explain only part of LDL variability in an FH family | In search of a genetic explanation for LDLc variability in an FH family: common SNPs and a rare mutation in MTTP explain only part of LDL variability in an FH family.
Winther M, Shpitzen S, Yaacov O, Landau J, Oren L, Foroozan-Rosenberg L, Lev Cohain N, Schurr D, Meiner V, Szalat A, Carmi S, Hayden MR, Leitersdorf E, Durst R., Free PMC Article | 06/27/2020 |
| The anti-sense strand of the human MTTP gene transcribes two noncoding RNAs. The MTTP-AS1-Long noncoding RNA is in the cytosol. | Identification of antisense transcripts of the microsomal triglyceride transfer protein genes in humans and mice.
Zhang S, Hussain MM., Free PMC Article | 06/13/2020 |
| Twenty-three patients were genetically confirmed as affected by primary hypobetalipoproteinemia. In this group of patients, the most prevalent mutated genes were APOB (in 17 patients, with eight novel mutations identified), SAR1B (in 3 patients, with one novel mutation identified), ANGPTL3 (in 2 patients), and MTTP (in 1 patient). The other 21 patients could not be genetically diagnosed with hypobetalipoproteinemia despit | Molecular analysis of APOB, SAR1B, ANGPTL3, and MTTP in patients with primary hypocholesterolemia in a clinical laboratory setting: Evidence supporting polygenicity in mutation-negative patients.
Blanco-Vaca F, Martin-Campos JM, Beteta-Vicente Á, Canyelles M, Martínez S, Roig R, Farré N, Julve J, Tondo M. | 05/16/2020 |
| The study demonstrates for the first time that MTP gene -493G/T polymorphism has not a major effect on the risk of HCV genotype 1-related hepatic steatosis. | Association between hepatic steatosis and MTP gene -493G/T polymorphism in the patients with HCV genotype 1 infection.
Akgöllü E, Akkız H. | 05/9/2020 |
| this study suggests that a single copy of the MTTP gene may be sufficient for human normal lipid absorption | Postprandial lipid absorption in seven heterozygous carriers of deleterious variants of MTTP in two abetalipoproteinemic families.
Di Filippo M, Varret M, Boehm V, Rabès JP, Ferkdadji L, Abramowitz L, Dumont S, Lenaerts C, Boileau C, Joly F, Schmitz J, Samson-Bouma ME, Bonnefont-Rousselot D. | 05/9/2020 |
| The crystal structure of human microsomal triglyceride transfer protein. | The crystal structure of human microsomal triglyceride transfer protein.
Biterova EI, Isupov MN, Keegan RM, Lebedev AA, Sohail AA, Liaqat I, Alanen HI, Ruddock LW., Free PMC Article | 03/28/2020 |
| Intestinal expression of MTP is negatively associated with plasma insulin concentrations and positively associated with plasma glucose concentrations.Duodenal expression of MTP was upregulated in type 2 diabetic patients compared with nondiabetic patients. | Differential associations between plasma concentrations of insulin and glucose and intestinal expression of key genes involved in chylomicron metabolism.
Drouin-Chartier JP, Tremblay AJ, Lemelin V, Lamarche B, Couture P. | 07/6/2019 |
| MTP polymorphisms (493G/G, G/T, T/T) do not seem to influence PNPLA3 in the development of liver steatosis in an Italian cohort with chronic hepatitis C. | No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis.
Zampino R, Macera M, Cirillo G, Pafundi PC, Rinaldi L, Coppola N, Pisaturo M, Adinolfi LE, Miraglia Del Giudice E, Ingrosso D, Capasso R. | 02/23/2019 |
| Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease | Complex genetic architecture in severe hypobetalipoproteinemia.
Wang LR, McIntyre AD, Hegele RA., Free PMC Article | 09/22/2018 |
| Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease. | Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD.
Boonvisut S, Yoshida K, Nakayama K, Watanabe K, Miyashita H, Iwamoto S., Free PMC Article | 06/2/2018 |
| The authors conclude that alternate splicing plays a key role in regulating cellular MTP levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP activity. | Discovery of Novel Splice Variants and Regulatory Mechanisms for Microsomal Triglyceride Transfer Protein in Human Tissues.
Suzuki T, Swift LL., Free PMC Article | 04/14/2018 |