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    MTHFR methylenetetrahydrofolate reductase [ Homo sapiens (human) ]

    Gene ID: 4524, updated on 9-Jul-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [Analysis of MTHFR gene variants in fifteen children with hyperhomocysteinemia].

    [Analysis of MTHFR gene variants in fifteen children with hyperhomocysteinemia].
    Liu F, Liang LL, Qiu WJ, Zhang HW, Zhan X, Xu F, Zhang Y, Zhang JM, Yang SH, Han LS.

    07/9/2024
    Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.

    Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.
    Huang Y, Su T, Duan Q, Wei X, Fan X, Wan J, Liu L, Dian Z, Zhang G, Sun Y, Zhou T, Xu Y., Free PMC Article

    06/28/2024
    MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico.

    MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico.
    Romero-Bolaño YM, Bobadilla-Morales L, Corona-Rivera A, Cuero-Quezada I, Santana-Hernández J, Peña-Padilla C, Brukman-Jiménez A, Orozco-Vela M, Navia-Espinoza N, Corona-Rivera JR.

    06/12/2024
    Retrospective cohort study of the MTHFR C677T/A1298C polymorphisms and human homocysteine levels in Helicobacter pylori infection.

    Retrospective cohort study of the MTHFR C677T/A1298C polymorphisms and human homocysteine levels in Helicobacter pylori infection.
    Oliveira APG, de Matos GCB, Vieira MCDS, Corvelo TCO.

    06/3/2024
    Effects of MTHFR C677T polymorphism on homocysteine and vitamin D in women with polycystic ovary syndrome.

    Effects of MTHFR C677T polymorphism on homocysteine and vitamin D in women with polycystic ovary syndrome.
    Zhao J, Li X, Chen Q.

    05/29/2024
    Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention.

    Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention.
    Shi Y, Zhang Z, Wang B, Wang Y, Kong X, Sun Y, Li A, Cui Y, Zhang Y, Li J, Huo Y, Huang H., Free PMC Article

    05/13/2024
    Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects.

    Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects.
    Nasri K, Ben Jamaa N, Gaigi SS, Feki M, Marrakchi R.

    05/9/2024
    Homozygous MTHFR C677T carriers develop idiopathic portal vein thrombosis 20 years earlier than wild type.

    Homozygous MTHFR C677T carriers develop idiopathic portal vein thrombosis 20 years earlier than wild type.
    Ames PR, D'Andrea G, Arcaro A, Marottoli V, Iannaccone L, Margaglione M, Gentile F.

    05/9/2024
    Skin disorders in women with poor obstetric history: MTHFR polymorphisms and importance of preconceptional counseling.

    Skin disorders in women with poor obstetric history: MTHFR polymorphisms and importance of preconceptional counseling.
    Cagan M, Donmez HG, Fadiloglu E, Beksac MS.

    05/9/2024
    Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy.

    Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy.
    Asadi S, Rahimi Z, Kohsari M, Babajani F, Amiri M, Jalilian N, Naseri R, Haghnazari L.

    05/3/2024
    MTHFR and MTRR gene polymorphisms in patients with chronic hepatitis B virus infections in Zigong, Sichuan Province.

    MTHFR and MTRR gene polymorphisms in patients with chronic hepatitis B virus infections in Zigong, Sichuan Province.
    Qiu S, Jin L, Yang D, Zhang D.

    05/2/2024
    [Analysis of 9 patients with adolescence-onset methylenetetrahydrofolate reductase deficiency].

    [Analysis of 9 patients with adolescence-onset methylenetetrahydrofolate reductase deficiency].
    Zhang HT, Ma X, Jin Y, Li MQ, Song JQ, Chen ZH, Liu Y, Lu XP, Zheng H, Yang YL.

    03/31/2024
    Interaction effects of MTHFR C677T and A1298C polymorphisms with maternal glycated haemoglobin levels on adverse birth outcomes.

    Interaction effects of MTHFR C677T and A1298C polymorphisms with maternal glycated haemoglobin levels on adverse birth outcomes.
    Wu W, Luo D, Ji C, Diao F, Wu L, Ruan X, Gu C, Luo M.

    03/26/2024
    Association between MTHFR C677T Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia.

    Association between MTHFR C677T Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia.
    Li ZC, Huang M, Yao QY, Lin CH, Hong BC, Wang JH, Zhang Z.

    03/1/2024
    Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation.

    Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation.
    Diaz-Garcia H, Vilchis-Gil J, Castro-Cerritos KV, Rivera-Susunaga LE, Klünder-Klünder M, Granados-Riveron JT, Gómez-López J, López-Torres A, Sánchez-Urbina R.

    02/12/2024
    Congenital septal defects in Karachi, Pakistan: an update of mutational screening by high-resolution melting (HRM) analysis of MTHFR C677T.

    Congenital septal defects in Karachi, Pakistan: an update of mutational screening by high-resolution melting (HRM) analysis of MTHFR C677T.
    Ali SI, Khan OY, Naveed N, Ahmad H, Patel N, Arif A., Free PMC Article

    02/8/2024
    Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension.

    Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension.
    Zhang C, Xin QP, Xie YB, Guo XY, Xing EH, Dou ZJ, Zhao C., Free PMC Article

    01/31/2024
    Association of methylenetetrahydrofolate reductase gene variant C677T and folate levels in non-syndromic cleft lip/palate among Sindhi, Pakistani population.

    Association of methylenetetrahydrofolate reductase gene variant C677T and folate levels in non-syndromic cleft lip/palate among Sindhi, Pakistani population.
    Effendi S, Memon S, Khidri FF, Waryah AM.

    01/17/2024
    A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression.

    A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression.
    Sudershan A, Pushap AC, Kumar H, Kumar P.

    01/5/2024
    Association study between genetic polymorphisms in MTHFR and stroke susceptibility in Egyptian population: a case-control study.

    Association study between genetic polymorphisms in MTHFR and stroke susceptibility in Egyptian population: a case-control study.
    El-Khawaga OY, Al-Azzawy MF, El-Dawa AN, ElSaid AM, Mustafa W, Saad M., Free PMC Article

    01/5/2024
    MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.

    MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
    Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, Turnbull I, Yang L, Lv J, Yu C, Davey Smith G, Wang Y, Wang Y, Peto R, Collins R, Walters RG, Li L, Chen Z, Clarke R, China Kadoorie Biobank (CKB) Study Collaborative Group., Free PMC Article

    12/27/2023
    Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: A meta-analysis of case-control studies.

    Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: A meta-analysis of case-control studies.
    Ginani CTA, da Luz JRD, de Medeiros KS, Sarmento ACA, Coppedè F, das Graças Almeida M.

    12/22/2023
    A study on the correlation between MTHFR and folic acid combined with trace elements for the prevention of fetal malformations in the first trimester of pregnancy.

    A study on the correlation between MTHFR and folic acid combined with trace elements for the prevention of fetal malformations in the first trimester of pregnancy.
    Zhang H, Pan J, Jiang H, Xiong X, Huang L, Liu X, Wangzi WX, Chen L., Free PMC Article

    11/28/2023
    Association between MTHFR gene C677T polymorphism and gestational diabetes mellitus in Chinese population: a meta-analysis.

    Association between MTHFR gene C677T polymorphism and gestational diabetes mellitus in Chinese population: a meta-analysis.
    Tan X, Chen H., Free PMC Article

    11/16/2023
    Association of MTHFR Polymorphisms With Leukoencephalopathy Risk in Patients With Primary CNS Lymphoma Treated With Methotrexate-Based Regimens.

    Association of MTHFR Polymorphisms With Leukoencephalopathy Risk in Patients With Primary CNS Lymphoma Treated With Methotrexate-Based Regimens.
    Karschnia P, Kurz SC, Brastianos PK, Winter SF, Gordon A, Jones S, Pisapia M, Nayyar N, Tonn JC, Batchelor TT, Plotkin SR, Dietrich J.,

    11/10/2023
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