| MTF1 genetic variants are associated with lung cancer risk in the Chinese Han population. | MTF1 genetic variants are associated with lung cancer risk in the Chinese Han population.
Cheng Y, Zhang C, Li Q, Yang X, Chen W, He K, Chen M., Free PMC Article | 09/8/2024 |
| Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis. | Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis.
Huang F, Su Z, Yang J, Zhao X, Xu Y. | 07/19/2024 |
| Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells. | Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells.
Wright GM, Black JC., Free PMC Article | 04/14/2023 |
| MTF1 heads a hierarchy of zinc sensors, and through controlling the expression of a raft of metallothioneins and other key proteins involved in controlling intracellular zinc levels (e.g. ZnT1) alters zinc buffering capacity and total cellular zinc content. | Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc.
Hardyman JE, Tyson J, Jackson KA, Aldridge C, Cockell SJ, Wakeling LA, Valentine RA, Ford D. | 12/17/2016 |
| MTF-1 has a role in regulating zinc dependent cellular processes at the molecular level [review] | Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level.
Grzywacz A, Gdula-Argasińska J, Muszyńska B, Tyszka-Czochara M, Librowski T, Opoka W. | 07/30/2016 |
| Forty-one single nucleotide polymorphisms (SNPs) within the MTF1 gene region. | Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc.
Adams SV, Barrick B, Christopher EP, Shafer MM, Makar KW, Song X, Lampe JW, Vilchis H, Ulery A, Newcomb PA., Free PMC Article | 03/12/2016 |
| Human ZnT2 expression is regulated by MTF-1. | Coordinative modulation of human zinc transporter 2 gene expression through active and suppressive regulators.
Lu YJ, Liu YC, Lin MC, Chen YT, Lin LY. | 02/13/2016 |
| Zn-responsive proteome profiling and time-dependent expression of proteins are regulated by MTF-1 in human alveolar epithelial cells. | Zn-responsive proteome profiling and time-dependent expression of proteins regulated by MTF-1 in A549 cells.
Zhao WJ, Song Q, Wang YH, Li KJ, Mao L, Hu X, Lian HZ, Zheng WJ, Hua ZC., Free PMC Article | 05/30/2015 |
| The zinc-sensing cytoplasmic transcription factor MTF-1 plays a key role in cellular zinc homoeostasis. | Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter.
Kukic I, Lee JK, Coblentz J, Kelleher SL, Kiselyov K., Free PMC Article | 06/1/2013 |
| Results identify a cysteine cluster that mediates homodimerization of human MTF-1, and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity. | A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1).
Günther V, Davis AM, Georgiev O, Schaffner W. | 05/12/2012 |
| Variations in the ability of LAT1/DMT1/MTF1/MT1a to process and transport Hg may not play a significant role in the etiology of autism. | Lack of association between autism and four heavy metal regulatory genes.
Owens SE, Summar ML, Ryckman KK, Haines JL, Reiss S, Summar SR, Aschner M., Free PMC Article | 05/5/2012 |
| It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm | The role of small ubiquitin-like modifier-interacting motif in the assembly and regulation of metal-responsive transcription factor 1.
Liu YC, Lin MC, Chen HC, Tam MF, Lin LY., Free PMC Article | 03/31/2012 |
| Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1. | Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.
McHugh PC, Wright JA, Brown DR., Free PMC Article | 09/3/2011 |
| Zinc and cadmium can activate FPN1 transcription through the MTF-1. | Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.
Troadec MB, Ward DM, Lo E, Kaplan J, De Domenico I., Free PMC Article | 01/15/2011 |
| Data show that hepcidin transcription involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. | Divalent metal-dependent regulation of hepcidin expression by MTF-1.
Balesaria S, Ramesh B, McArdle H, Bayele HK, Srai SK. | 05/10/2010 |
| Genetic regulation via sequences downstream of promoters highlights a new direction for identifying previously unrecognized target genes for MTF-1. | Metal transcription factor-1 regulation via MREs in the transcribed regions of selenoprotein H and other metal-responsive genes.
Stoytcheva ZR, Vladimirov V, Douet V, Stoychev I, Berry MJ., Free PMC Article | 05/10/2010 |
| Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in intrahepatic cholangiocarcinoma | Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor.
Takamura M, Yamagiwa S, Wakai T, Tamura Y, Kamimura H, Kato T, Tsuchiya A, Matsuda Y, Shirai Y, Ichida T, Ajioka Y, Aoyagi Y. | 03/1/2010 |
| show that the acidic activation domain of hMTF-1 can work as a zinc-inducible activation domain independent of the full-length protein context. | Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain.
Lindert U, Cramer M, Meuli M, Georgiev O, Schaffner W., Free PMC Article | 01/21/2010 |
| Findings suggest that MTF-1 is involved in hypoxia-dependent regulation of PlGF in trophoblast-derived cells. | Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells.
Nishimoto F, Sakata M, Minekawa R, Okamoto Y, Miyake A, Isobe A, Yamamoto T, Takeda T, Ishida E, Sawada K, Morishige K, Kimura T. | 01/21/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma.
Akulevich NM, Saenko VA, Rogounovitch TI, Drozd VM, Lushnikov EF, Ivanov VK, Mitsutake N, Kominami R, Yamashita S. | 03/25/2009 |
| SP1 and MTF-1 represent new targets in the development of key therapeutics toward modulating the expression of the cellular prion protein and ultimately the prevention of prion disease | Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.
Bellingham SA, Coleman LA, Masters CL, Camakaris J, Hill AF. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM. Genetic susceptibility to environmental toxicants in ALS.
Morahan JM, Yu B, Trent RJ, Pamphlett R. | 03/13/2008 |
| MTF1 transactivation potential is affected by chromium levels | Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.
Majumder S, Ghoshal K, Summers D, Bai S, Datta J, Jacob ST., Free PMC Article | 01/21/2010 |
| The MTF-1 serves targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration and under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene PIGF. | Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.
Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W. | 01/21/2010 |
| role in regulating metallothionein transcription | Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.
Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH. | 01/21/2010 |