| Helicobacter pylori vacA affects the expression of COX-2 in the duodenal mucosa of patients with duodenitis. | Helicobacter pylori vacA affects the expression of COX-2 in the duodenal mucosa of patients with duodenitis.
Chu Y, Chen F, Pan Q, Cheng N, Liu X, Feng J. | 02/27/2024 |
| 15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection. | 15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.
Kianfar S, Salimi V, Jahangirifard A, Mirtajani SB, Vaezi MA, Yavarian J, Mokhtari-Azad T, Tavakoli-Yaraki M. | 10/11/2023 |
| Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma. | Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma.
Uslukaya O, Yegin Z, Taskesen F, Yildirim IH. | 08/25/2023 |
| Interferon-gamma is quintessential for NOS2 and COX2 expression in ER[-] breast tumors that lead to poor outcome. | Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome.
Cheng RYS, Ridnour LA, Wink AL, Gonzalez AL, Femino EL, Rittscher H, Somasundaram V, Heinz WF, Coutinho L, Rangel MC, Edmondson EF, Butcher D, Kinders RJ, Li X, Wong STC, McVicar DW, Anderson SK, Pore M, Hewitt SM, Billiar TR, Glynn SA, Chang JC, Lockett SJ, Ambs S, Wink DA., Free PMC Article | 06/2/2023 |
| Immunohistochemical Study and Clinicopathologic Correlation of Cox-2 and Her-2 Expression in Colorectal Carcinoma: A 5-Year Retrospective Study. | Immunohistochemical Study and Clinicopathologic Correlation of Cox-2 and Her-2 Expression in Colorectal Carcinoma: A 5-Year Retrospective Study.
Odukoya LA, Badmos KB, Khramtsova G, Adebayo LA, Olopade OI, Abdulkareem FB. | 12/10/2022 |
| Mitochondrial gene COX2 methylation and downregulation is a biomarker of aging in heart mesenchymal stem cells. | Mitochondrial gene COX2 methylation and downregulation is a biomarker of aging in heart mesenchymal stem cells.
Sun X, Wang Z, Cong X, Lv Y, Li Z, Rong L, Yang T, Yu D., Free PMC Article | 07/17/2021 |
| Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain. | Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H. | 02/6/2021 |
| Novel Point Mutations in Mitochondrial MT-CO2 Gene May Be Risk Factors for Coronary Artery Disease. | Novel Point Mutations in Mitochondrial MT-CO2 Gene May Be Risk Factors for Coronary Artery Disease.
Heidari MM, Mirfakhradini FS, Tayefi F, Ghorbani S, Khatami M, Hadadzadeh M. | 02/2/2021 |
| COX-1, COX-2, and CD147 appear to be independently regulated in oral squamous cell carcinoma (OSCC), potentially representing 2 therapeutic targets for future investigation. COX-1 expression in OSCC deserves further study because it may be an important determinant of PGE2 secretion from OSCC cells | Cyclooxygenase and CD147 expression in oral squamous cell carcinoma patient samples and cell lines.
Nasry WHS, Wang H, Jones K, Tesch M, Rodriguez-Lecompte JC, Martin CK. | 02/1/2020 |
| MT-CO2 mutation m.8088delT resulting in a premature stop codon was identified in a patient with myopathy and perturbed acylcarnitine profile. | Mitochondrial complex IV deficiency caused by a novel frameshift variant in MT-CO2 associated with myopathy and perturbed acylcarnitine profile.
Roos S, Sofou K, Hedberg-Oldfors C, Kollberg G, Lindgren U, Thomsen C, Tulinius M, Oldfors A., Free PMC Article | 05/11/2019 |
| Studied Cyclooxygenase-2 (COX-2) gene polymorphisms in a Turkish population with thyroid cancer; found the COX-2-8473T>C gene polymorphism may cause genetic susceptibility to thyroid cancer as compared to the control group. | Cyclooxygenase-2 (COX-2) gene polymorphism in patients with differentiated thyroid carcinomas in the Turkish population.
Uçan B, Özbek M, Şahin M, Kızılgül M, Çakal E. | 01/5/2019 |
| Study shows that higher COX-2 and ALOX5 expression in colorectal cancer (CRC) tissues was correlated with poorer prognosis in patients with CRC. Also, MiR-216a-3p was shown to directly bind to there 3'-UTR and inversely regulates their protein levels modulating CRC cell proliferation. | MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Wang D, Li Y, Zhang C, Li X, Yu J. | 11/3/2018 |
| Data suggest that mutations in MT-CO2 and MT-ND5 can be involved in MIDD (maternally inherited diabetes and deafness); a Tunisian family (mother, daughter, son) with clinical features of MIDD associated with retinopathy exhibit mutations in MT-CO2 (m.8241T>G - p. F219C) and MT-ND5 (m.13276G>A - p. M314V); these two mutations could explain retinopathy in some family members. (MT-ND5 = NADH dehydrogenase subunit 5) | Whole mitochondrial genome screening of a family with maternally inherited diabetes and deafness (MIDD) associated with retinopathy: A putative haplotype associated to MIDD and a novel MT-CO2 m.8241T>G mutation.
Tabebi M, Charfi N, Kallabi F, Alila-Fersi O, Ben Mahmoud A, Tlili A, Keskes-Ammar L, Kamoun H, Abid M, Mnif M, Fakhfakh F. | 03/3/2018 |
| Results demonstrates that the presence of high levels of COX-2 is associated with poor prognosis for breast cancer patients and predicts bigger tumor size and lymph node metastasis. [metastasis] | Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis.
Xu F, Li M, Zhang C, Cui J, Liu J, Li J, Jiang H., Free PMC Article | 02/24/2018 |
| results demonstrated that XRCC5 promoted colon cancer growth by cooperating with p300 to regulate COX-2 expression, and suggested that the XRCC5/p300/COX-2 signaling pathway was a potential target in the treatment of colon cancers | XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.
Zhang Z, Zheng F, Yu Z, Hao J, Chen M, Yu W, Guo W, Chen Y, Huang W, Duan Z, Deng W., Free PMC Article | 11/26/2017 |
| inhibitory effects of 17-AAG on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 and 15-PGDH expression. | HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
Mohammadi A, Yaghoobi MM, Gholamhoseinian Najar A, Kalantari-Khandani B, Sharifi H, Saravani M. | 03/11/2017 |
| The sequencing analysis revealed the presence of 17 variants, mostly causing non-synonymous changes in conserved amino acid residues, typically distributed in the MT-CO2 gene of MUTYH-associated polyposis patients (P < 0.0001), who frequently carried the hot spot m.7763G>A variant. | Mitochondrial variants in MT-CO2 and D-loop instability are involved in MUTYH-associated polyposis.
Errichiello E, Balsamo A, Cerni M, Venesio T. | 08/27/2016 |
| Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2. | COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.
Stroud DA, Maher MJ, Lindau C, Vögtle FN, Frazier AE, Surgenor E, Mountford H, Singh AP, Bonas M, Oeljeklaus S, Warscheid B, Meisinger C, Thorburn DR, Ryan MT. | 07/16/2016 |
| Mutational analysis show a novel MTCO2 mutation 8249G>A pathogenic variation in Tunisian patients with mitochondrial myopathy. | A novel MT-CO2 m.8249G>A pathogenic variation and the MT-TW m.5521G>A mutation in patients with mitochondrial myopathy.
Mkaouar-Rebai E, Ben Mahmoud A, Chamkha I, Chabchoub I, Kammoun T, Hachicha M, Fakhfakh F. | 10/24/2015 |
| We also detected in 4 asthenospermic patients a double novels mutations, the first was found in COXII gene (m.8021 G/A) that was absent in normospermic infertile men. | Two novel mutations in COII and tRNA(His) mitochondrial genes in asthenozoospermic infertiles men.
Siwar BG, Myriam G, Afif BM, Emna MR, Nozha C, Afifa S, Faiza F, Leila AK. | 09/27/2014 |
| The presence of a non-synonymous variation in the COII strongly correlated with poor survival in patients with cytogenetically normal acute myeloid leukemia. | Mitochondrial cytochrome c oxidase subunit II variations predict adverse prognosis in cytogenetically normal acute myeloid leukaemia.
Silkjaer T, Nyvold CG, Juhl-Christensen C, Hokland P, Nørgaard JM. | 04/26/2014 |
| Protein modeling revealed loss of function mutations of ND6 and COX-II proteins in malignant vs benign tumors | Mitochondria and tumors: a new perspective.
Chintha R, Kaipa PR, Sekhar N, Hasan Q. | 03/22/2014 |
| COX-2 expression played an essential role in the proliferation and metastasis of tongue cancer. | COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway.
Wang YH, Wu MW, Yang AK, Zhang WD, Sun J, Liu TR, Chen YF. | 08/25/2012 |
| Novel COII mutations responsible for maternally inherited nonsyndromic hearing loss | Novel mitochondrial DNA mutations responsible for maternally inherited nonsyndromic hearing loss.
Gutiérrez Cortés N, Pertuiset C, Dumon E, Börlin M, Hebert-Chatelain E, Pierron D, Feldmann D, Jonard L, Marlin S, Letellier T, Rocher C. | 07/14/2012 |
| The apoptotic index of pulmonary vascular endothelial cells was negatively correlated with COXII expression in patients with chronic obstructive pulmonary disease. | [Cytochrome C oxidase expression and endothelial cell apoptosis in lungs of patients with chronic obstructive pulmonary disease].
Yang M, Chen P, Peng H, Shen Q, Chen Y. | 12/17/2011 |