| Apo-metallothionein-3 cooperatively forms tightly compact structures under physiological conditions. | Apo-metallothionein-3 cooperatively forms tightly compact structures under physiological conditions.
Yuan AT, Korkola NC, Stillman MJ., Free PMC Article | 04/5/2023 |
| Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells. | Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.
Kalyan G, Slusser-Nore A, Dunlevy JR, Bathula CS, Shabb JB, Muhonen W, Somji S, Sens DA, Garrett SH., Free PMC Article | 05/21/2022 |
| Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa. | Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa.
Suzuki M, Ramezanpour M, Cooksley C, Ogi K, Psaltis AJ, Nakamaru Y, Homma A, Wormald PJ, Vreugde S. | 12/25/2021 |
| Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma. | Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma.
Rodrigo MAM, Michalkova H, Strmiska V, Casar B, Crespo P, de Los Rios V, Ignacio Casal J, Haddad Y, Guran R, Eckschlager T, Pokorna P, Heger Z, Adam V., Free PMC Article | 12/11/2021 |
| miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3. | miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3.
Sun S, Liu F, Xian S, Cai D., Free PMC Article | 02/20/2021 |
| Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd3S9. | Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd(3)S(9).
Yuan G, Ma Q, Wu T, Wang M, Li X, Zuo J, Zheng P., Free PMC Article | 11/21/2020 |
| We have demonstrated the relationship between MT-3 and senescence-induced oncogene genes and some other genes relevant to cell fate (glutathione S-transferase M3, caspase 4 and DNAJB6) and a significant proportion of MT-3 on cisplatin resistance. High levels of MT-3 in high-risk neuroblastoma could be one of the causes of frequent relapses in this tumor. | [Identifying the Importance of MT-3 Expression for Neuroblastoma Cells].
Eckschlager T, Vícha A, Jenčová P, Merlos R, Dostálová S, Buchtelová H, Strmiska V, Michálek P, Heger Z, Adam V. | 09/7/2019 |
| MT3 is an arsenic- and hypoxia-upregulated oncogene that promotes cell growth and invasion of bladder carcinoma cells via downregulation of NDRG1, NDRG2, and MASPIN expressions. | Metallothionein 3 Is a Hypoxia-Upregulated Oncogene Enhancing Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells.
Tsui KH, Hou CP, Chang KS, Lin YH, Feng TH, Chen CC, Shin YS, Juang HH., Free PMC Article | 06/8/2019 |
| This study suggest that MT3 gene polymorphisms are not associated with autism. | Association Study Between Metallothionein-3 Protein Polymorphisms and Autism.
Yu M, Cao T, Yu D, Huang F. | 12/22/2018 |
| In recent years, the roles of zinc dynamics and MT3 function in neurodegeneration are slowly emerging. This short review focuses on the recent developments regarding the chemistry and biology of MT3. [review] | Mammalian Metallothionein-3: New Functional and Structural Insights.
Vašák M, Meloni G., Free PMC Article | 03/10/2018 |
| C-terminal domain of MT3 confers dome formation in MCF-7 cells and the presence of this domain induces expression of the GAGE family of genes. The differential effects of MT3 and metallothionein 1E on the expression of GAGE genes suggests unique roles of these genes in the development and progression of breast cancer. | The unique C- and N-terminal sequences of Metallothionein isoform 3 mediate growth inhibition and Vectorial active transport in MCF-7 cells.
Voels B, Wang L, Sens DA, Garrett SH, Zhang K, Somji S., Free PMC Article | 03/3/2018 |
| The expression of MT-3 mRNA in breast cancer cell lines was significantly lower than in the normal human breast epithelial cell line. The results suggest that MT-3 may play a role in the malignant transformation of breast epithelial cells and in tumor progression. | Expression of metallothionein 3 in ductal breast cancer.
Gomulkiewicz A, Jablonska K, Pula B, Grzegrzolka J, Borska S, Podhorska-Okolow M, Wojnar A, Rys J, Ambicka A, Ugorski M, Zabel M, Dziegiel P. | 04/22/2017 |
| The epidermis of human skin and resulting malignancies express high level of MT-3. | Metallothionein isoform 3 expression in human skin, related cancers and human skin derived cell cultures.
Slusser A, Zheng Y, Zhou XD, Somji S, Sens DA, Sens MA, Garrett SH. | 02/18/2017 |
| The present study was undertaken to explore further the interrelationship between p53 and metallothioneins. | Basal and copper-induced expression of metallothionein isoform 1,2 and 3 genes in epithelial cancer cells: The role of tumor suppressor p53.
Ostrakhovitch EA, Song YP, Cherian MG. | 12/24/2016 |
| The study implicates the unique C-terminal sequence of MT-3 in the conversion of HK-2 cells to display an enhanced epithelial phenotype. | Cadherin expression, vectorial active transport, and metallothionein isoform 3 mediated EMT/MET responses in cultured primary and immortalized human proximal tubule cells.
Slusser A, Bathula CS, Sens DA, Somji S, Sens MA, Zhou XD, Garrett SH., Free PMC Article | 02/27/2016 |
| MT3 may regulate breast cancer cell invasiveness by modulating the expression of MMP3. | Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
Kmiecik AM, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P., Free PMC Article | 01/30/2016 |
| The presence of MT-3 in the zona glomerulosa of pathological adrenal cortex may imply a role in the pathophysiology of aldosterone-producing tissues. | Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders.
Felizola SJ, Nakamura Y, Arata Y, Ise K, Satoh F, Rainey WE, Midorikawa S, Suzuki S, Sasano H. | 05/23/2015 |
| MT-capital I, Ukrainiancapital I, Ukrainiancapital I, Ukrainian increases the amount of active ADAM10 in association with furin, PC7 and PKCalpha. | Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing.
Park BH, Kim HG, Jin SW, Song SG, Jeong HG. | 08/16/2014 |
| Upregulation of MT-3 gene expression can inhibit esophageal cancer cell proliferation and induce apoptosis. | Effects of metallothionein-3 and metallothionein-1E gene transfection on proliferation, cell cycle, and apoptosis of esophageal cancer cells.
Tian ZQ, Xu YZ, Zhang YF, Ma GF, He M, Wang GY. | 07/5/2014 |
| The experiments indicate that MT3 is an androgen-upregulated gene, and promotes tumorigenesis of prostate carcinoma cells. | Metallothionein 3: an androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells.
Juang HH, Chung LC, Sung HC, Feng TH, Lee YH, Chang PL, Tsui KH. | 01/4/2014 |
| the molecular mechanism for protection against the neuronal cytotoxicity of Abeta(1-42) with copper ions | The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ(1-42) with Cu ions.
Luo Y, Xu Y, Bao Q, Ding Z, Zhu C, Huang ZX, Tan X. | 06/8/2013 |
| MT-III expression may have an impact on the pathogenesis of non-small cell lung cancer. | Expression of metallothionein-III in patients with non-small cell lung cancer.
Werynska B, Pula B, Muszczynska-Bernhard B, Gomulkiewicz A, Jethon A, Podhorska-Okolow M, Jankowska R, Dziegiel P. | 05/18/2013 |
| MT-3 modulates the catalytic redox properties of PrP-Cu(II) | The catalytic redox activity of prion protein-Cu(II) is controlled by metal exchange with the Zn(II) -thiolate clusters of Zn(7) metallothionein-3.
Meloni G, Crameri A, Fritz G, Davies P, Brown DR, Kroneck PM, Vašák M. | 10/13/2012 |
| Esophageal adenocarcinomas are characterized by frequent epigenetic silencing of MT3. | Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas.
Peng D, Hu TL, Jiang A, Washington MK, Moskaluk CA, Schneider-Stock R, El-Rifai W., Free PMC Article | 12/10/2011 |
| Metallothionein-III is a specific component of glial cytoplasmic inclusions and is upregulated in multiple system atrophy. | Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy.
Pountney DL, Dickson TC, Power JH, Vickers JC, West AJ, Gai WP. | 11/12/2011 |