| MT1X is an oncogene and indicates prognosis in ccRCC. | MT1X is an oncogene and indicates prognosis in ccRCC.
Ding Y, Fang J, Chen M, Xu Y, Liu N, Fang S, Xiang W, Chen R, Wu C, Yu H., Free PMC Article | 10/29/2022 |
| Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival. | Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
Masiulionytė B, Valiulytė I, Tamašauskas A, Skiriutė D., Free PMC Article | 10/10/2020 |
| we featured the expression patterns of MT1s in tissue obtained from various points along the spectrum of hepatocarcinogenesis. Most MT1 members were down-regulated, and MT1X were associated with HCC prognosis. Additionally, MT1X was shown to play a suppressive role in HCC metastasis. | Metallothionein 1 family profiling identifies MT1X as a tumor suppressor involved in the progression and metastastatic capacity of hepatocellular carcinoma.
Liu Z, Ye Q, Wu L, Gao F, Xie H, Zhou L, Zheng S, Xu X. | 05/11/2019 |
| Data show that in the MCF-7 breast cancer cell line, only MT1X metallothioneins (MTs) positively correlated with vascular endothelial growth factor C (VEGFC). | Expression of Metallothionein and Vascular Endothelial Growth Factor Isoforms in Breast Cancer Cells.
Wierzowiecka B, Gomulkiewicz A, Cwynar-Zajac L, Olbromski M, Grzegrzolka J, Kobierzycki C, Podhorska-Okolow M, Dziegiel P. | 03/25/2017 |
| MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker showing Microsatellite Instability is associated with Persian Lynch Syndrome | Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients.
Farahani N, Nikpou P, Emami MH, Hashemzadeh M, Zeinalian M, Shariatpanahi SS, Salehi R. | 02/18/2017 |
| These findings suggest that functional interactions between FHL3 and MT-1X may provide some clues to the mechanisms of FHL3-regulated cell proliferation. | Identification and characterization of MT-1X as a novel FHL3-binding partner.
Cai X, Wang J, Huang X, Fu W, Xia W, Zou M, Wang Y, Wang J, Xu D., Free PMC Article | 06/20/2015 |
| Results show variation in MTX1 is implicated in disordered gambling | Genome-wide association study of a quantitative disordered gambling trait.
Lind PA, Zhu G, Montgomery GW, Madden PA, Heath AC, Martin NG, Slutske WS., Free PMC Article | 10/19/2013 |
| siRNA-mediated knockdown of TCRP1 and MT1X was found to sensitize cells to cisplatin, leading to increased apoptosis and inhibition of cell proliferation | Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
Peng B, Gu Y, Xiong Y, Zheng G, He Z., Free PMC Article | 06/15/2013 |
| Our results suggest that MT1XT20 represents a sensitive and specific marker for MSI testing and could be included in a complete set of MSI markers for the confident identification of familial or sporadic dMMR patients in colorectal cancers. | T([20]) repeat in the 3'-untranslated region of the MT1X gene: a marker with high sensitivity and specificity to detect microsatellite instability in colorectal cancer.
Morandi L, de Biase D, Visani M, Monzoni A, Tosi A, Brulatti M, Turchetti D, Baccarini P, Tallini G, Pession A. | 04/20/2013 |
| MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts. | Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
Toh PP, Li JJ, Yip GW, Lo SL, Guo CH, Phan TT, Bay BH. | 04/30/2011 |
| Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia. | Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
Raymond AD, Gekonge B, Giri MS, Hancock A, Papasavvas E, Chehimi J, Kossenkov AV, Nicols C, Yousef M, Mounzer K, Shull J, Kostman J, Showe L, Montaner LJ., Free PMC Article | 10/4/2010 |
| It plays a role in the detoxification of heavy metals and reactive oxygen species. (review) | [Cilostazol induces metallothionein expression in vascular cells].
Fujiwara Y, Kitagawa T, Shinkai Y, Kaji T, Satoh M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.
Segat L, Milanese M, Pirulli D, Trevisiol C, Lupo F, Salizzoni M, Amoroso A, Crovella S. | 12/2/2009 |