| we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed. | Significance of the rapid increase in GSH levels in the protective response to cadmium exposure through phosphorylated Nrf2 signaling in Jurkat T-cells.
Ogasawara Y, Takeda Y, Takayama H, Nishimoto S, Ichikawa K, Ueki M, Suzuki T, Ishii K. | 11/22/2014 |
| Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma. | Immunohistochemical expression of metallothionein in pleomorphic adenoma of minor salivary glands: a role in the control of apoptosis?
Miranda Viana Ade C, Ribeiro DC, Florêncio TN, Santos VT, Sousa AA, Aguiar MC. | 10/19/2013 |
| Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression. | Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2.
Miao X, Wang Y, Sun J, Sun W, Tan Y, Cai L, Zheng Y, Su G, Liu Q, Wang Y., Free PMC Article | 10/19/2013 |
| findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy | Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients.
Werynska B, Pula B, Muszczynska-Bernhard B, Gomulkiewicz A, Piotrowska A, Prus R, Podhorska-Okolow M, Jankowska R, Dziegiel P. | 04/6/2013 |
| MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue | Downregulation of metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue.
Yan DW, Fan JW, Yu ZH, Li MX, Wen YG, Li DW, Zhou CZ, Wang XL, Wang Q, Tang HM, Peng ZH. | 09/29/2012 |
| This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression. | Metallothionein expression in colorectal cancer: relevance of different isoforms for tumor progression and patient survival.
Arriaga JM, Levy EM, Bravo AI, Bayo SM, Amat M, Aris M, Hannois A, Bruno L, Roberti MP, Loria FS, Pairola A, Huertas E, Mordoh J, Bianchini M. | 03/10/2012 |
| Studies provide the mechanistic properties of metal binding for metallothionein metallation. | The "magic numbers" of metallothionein.
Sutherland DE, Stillman MJ. | 10/8/2011 |
| MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma. | Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma.
Zavras AI, Yoon AJ, Chen MK, Lin CW, Yang SF. | 09/3/2011 |
| MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts. | Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
Toh PP, Li JJ, Yip GW, Lo SL, Guo CH, Phan TT, Bay BH. | 04/30/2011 |
| Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages. | Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages.
Huang YC, Li Z, Carter JD, Soukup JM, Schwartz DA, Yang IV., Free PMC Article | 01/21/2010 |
| In the liver cancer tissue, MT1F shows down-regulated expression that supports the inhibited function of MT1F in cancer growth | The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma.
Lu DD, Chen YC, Zhang XR, Cao XR, Jiang HY, Yao L., Free PMC Article | 01/21/2010 |