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    PRL prolactin [ Ovis aries (sheep) ]

    Gene ID: 443317, updated on 19-Aug-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A novel 23 bp indel mutation in PRL gene is associated with growth traits in Luxi Blackhead sheep.

    A novel 23 bp indel mutation in PRL gene is associated with growth traits in Luxi Blackhead sheep.
    Mao C, Akhatayeva Z, Cheng H, Zhang G, Jiang F, Meng X, Yao Y, Elnour IE, Lan X, Song E.

    01/1/2022
    ncc2b expression is dependent on prolactin's downstream activation of Stat5 and its subsequent nuclear translocation within branchial ionocytes.

    Prolactin controls Na(+),Cl(-) cotransporter via Stat5 pathway in the teleost gill.
    Bollinger RJ, Ellis LV, Bossus MC, Tipsmark CK.

    05/11/2019
    These results indicate that PRL, EGF and glucocorticoids have distinct roles in the establishment of beta-casein secretion pathway.

    Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in β-casein secretion pathway in lactating mammary epithelial cells.
    Kobayashi K, Oyama S, Kuki C, Tsugami Y, Matsunaga K, Suzuki T, Nishimura T.

    11/18/2017
    Prolactin induces apoptosis of lactotropes

    Prolactin induces apoptosis of lactotropes in female rodents.
    Ferraris J, Zárate S, Jaita G, Boutillon F, Bernadet M, Auffret J, Seilicovich A, Binart N, Goffin V, Pisera D., Free PMC Article

    02/28/2015
    Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.

    Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.
    Pauloin A, Chanat E.

    11/17/2012
    Differences in accessibility of the rat arcuate nucleus to sheep prolactin, together with intrinsic differences in neuroendocrine dopaminergic neurons, facilitate homeostatic feedback regulation of sheep prolactin release in the rat hypothalamus

    Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action.
    Sapsford TJ, Kokay IC, Ostberg L, Bridges RS, Grattan DR., Free PMC Article

    09/29/2012
    conclude that PRL is an important part of the regulation of the pituitary-gonadal system in moderately seasonal DLS rams; it seems to impair release of LH from gonadotrophs, help maintain functional integrity of Leydig cells, & promote testicular growth

    Prolactin regulation of testosterone secretion and testes growth in DLS rams at the onset of seasonal testicular recrudescence.
    Sanford LM, Baker SJ.

    03/15/2010
    circulating prolactin decreased (P<0.001) in response to leptin during long days.

    Seasonal effects of central leptin infusion on secretion of melatonin and prolactin and on SOCS-3 gene expression in ewes.
    Zieba DA, Szczesna M, Klocek-Gorka B, Molik E, Misztal T, Williams GL, Romanowicz K, Stepien E, Keisler DH, Murawski M.

    01/21/2010
    DNA polymorphism of 5' flanking region of prolactin gene and its association with litter size in sheep.

    DNA polymorphism of 5' flanking region of prolactin gene and its association with litter size in sheep.
    Chu MX, Wang XC, Jin M, Di R, Chen HQ, Zhu GQ, Fang L, Ma YH, Li K.

    01/21/2010
    PRL exerts protective effects on adult neurogenesis in the dentate gyrus under chronic stress conditions in mice.

    Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate.
    Torner L, Karg S, Blume A, Kandasamy M, Kuhn HG, Winkler J, Aigner L, Neumann ID., Free PMC Article

    01/21/2010
    These results demonstrate that TGF-beta abrogates prolactin-stimulated beta-casein gene expression in mammary epithelial cells through, at least in part, a Smad3-dependent mechanism.

    TGF-beta inhibits prolactin-induced expression of beta-casein by a Smad3-dependent mechanism.
    Wu WJ, Lee CF, Hsin CH, Du JY, Hsu TC, Lin TH, Yao TY, Huang CH, Lee YJ.

    01/21/2010
    Prolactin expressed in adult and fetal sheep brain could be involved in neurodevelopment and/or modulation of the neuroendocrine stress axis.

    Prolactin expression in the sheep brain.
    Roselli CE, Bocklandt S, Stadelman HL, Wadsworth T, Vilain E, Stormshak F.

    01/21/2010
    findings provide strong evidence that the circannual regulation of prolactin secretion, and its associated biology, derive from a pituitary-based timing mechanism

    Characterizing a mammalian circannual pacemaker.
    Lincoln GA, Clarke IJ, Hut RA, Hazlerigg DG.

    01/21/2010
    increased PRL concentration within the central nervous system (CNS) for a few days before oncoming ovulation has no inhibitory effect on tonic LH secretion

    The effects of prolonged, intracerebroventricular prolactin treatment on luteinizing hormone secretion, catecholaminergic activity and estrous behavior in ewes.
    Misztal T, Romanowicz K, Tomaszewska-Zaremba D, Wójcik-Gładysz A, Barcikowski B.

    01/21/2010
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