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    MIR346 microRNA 346 [ Homo sapiens (human) ]

    Gene ID: 442911, updated on 21-Jan-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1.

    CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1.
    Wang W, Liu J, Pan E.

    03/12/2022
    Tumor suppressor LHX6 upregulation contributes to the inhibitory effect of miR-346 knockdown on colorectal cancer cell growth.

    Tumor suppressor LHX6 upregulation contributes to the inhibitory effect of miR-346 knockdown on colorectal cancer cell growth.
    Li X, Zhou Y, Wen P, Yuan Y, Xiao Z, Shi H, Zhou H.

    02/5/2022
    Potential biomarker enhancing the activity of tuberculosis, hsa-miR-346.

    Potential biomarker enhancing the activity of tuberculosis, hsa-miR-346.
    Uno S, Nishimura T, Nishio K, Kohsaka A, Tamizu E, Nakano Y, Kagyo J, Nakajima Y, Arai R, Hasegawa H, Arakawa K, Kashimura S, Ishii R, Miyazaki N, Uwamino Y, Hasegawa N.

    01/8/2022
    Hsa_circ_0069244 acts as the sponge of miR-346 to inhibit non-small cell lung cancer progression by regulating XPC expression.

    Hsa_circ_0069244 acts as the sponge of miR-346 to inhibit non-small cell lung cancer progression by regulating XPC expression.
    Shi J, Wang H, Feng W, Huang S, An J, Wang L, Jiang J.

    01/1/2022
    CircTOP2A acts as a ceRNA for miR346 and contributes to glioma progression via the modulation of sushi domaincontaining 2.

    Circ‑TOP2A acts as a ceRNA for miR‑346 and contributes to glioma progression via the modulation of sushi domain‑containing 2.
    Sang J, Li X, Lv L, Zhang C, Zhang X, Li G., Free PMC Article

    05/8/2021
    The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression.

    The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression.
    Wróblewska JP, Lach MS, Ustaszewski A, Kulcenty K, Ibbs M, Jagiełło I, Suchorska WM, Marszałek A., Free PMC Article

    02/2/2021
    Oncomir MicroRNA-346 Is Upregulated in Colons of Patients With Primary Sclerosing Cholangitis.

    Oncomir MicroRNA-346 Is Upregulated in Colons of Patients With Primary Sclerosing Cholangitis.
    Kempinska-Podhorodecka A, Blatkiewicz M, Wunsch E, Krupa L, Gutkowski K, Milkiewicz P, Milkiewicz M., Free PMC Article

    11/21/2020
    High miR346 expression is associated with cell proliferation, migration, and invasion in renal carcinoma.

    LncRNA NBAT1 suppresses cell proliferation and migration via miR-346/GSK-3β axis in renal carcinoma.
    Xue S, Wang S, Li J, Guan H, Jiang S, Guo Y, Li Q.

    06/6/2020
    the hsa-miR-346 level was significantly higher in patients with sepsis than in the control group. Hsa-miR-346 inhibited the expression of SMAD3 by targeted its 3'UTR.

    Hsa-miR-346 plays a role in the development of sepsis by downregulating SMAD3 expression and is negatively regulated by lncRNA MALAT1.
    Yang Q, Cao K, Jin G, Zhang J.

    05/9/2020
    miR-346-5p promoted colorectal cancer cell growth in vitro and in vivo by targeting FBXL2 and activating the beta-catenin signaling. MiR-346-5p can be a promising target in colorectal cancer therapy.

    MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.
    Pan S, Wu W, Ren F, Li L, Li Y, Li W, Wang A, Liu D, Dong Y.

    02/15/2020
    miR-346 plays a role in upregulation of APP in the CNS and participates in maintaining APP regulation of Fe, which is disrupted in late stages of AD.

    Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease.
    Long JM, Maloney B, Rogers JT, Lahiri DK., Free PMC Article

    12/7/2019
    we proved that DGCR5 can rescue the inhibited levels of KLF14 repressed by miR-346 mimics in MHCC-97H and Hep3B cells. Taken together, it was indicated in our study that DGCR5 can restrain the progression of HCC through sponging miR-346 and modulating KLF14 in vitro.

    LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis.
    Wang YG, Liu J, Shi M, Chen FX.

    10/5/2019
    Authors conclude that circFBLIM1 may function as a competing endogenous RNA (ceRNA) to regulate FBLIM1 expression through sponging miR-346 to exert regulatory functions in HCC.

    circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346.
    Bai N, Peng E, Qiu X, Lyu N, Zhang Z, Tao Y, Li X, Wang Z., Free PMC Article

    03/30/2019
    High miR346 expression is associated with Hepatocellular carcinoma.

    miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis Suppressor 1 Expression.
    Guo Z, Li J, Sun J, Sun L, Zhou Y, Yu Z., Free PMC Article

    11/10/2018
    Serum hsa-miR-346 is a potentially useful biomarker of MAC pulmonary disease activity.

    hsa-miR-346 is a potential serum biomarker of Mycobacterium avium complex pulmonary disease activity.
    Nishimura T, Tamizu E, Uno S, Uwamino Y, Fujiwara H, Nishio K, Nakano Y, Shiono H, Namkoong H, Hoshino Y, Iwata S, Hasegawa N.

    05/19/2018
    Results show that aberrant miR-346 and miR-582 expression profiles in maternal plasma, fetal cord plasma and placenta samples were shown to be associated with preeclampsia, preterm delivery, and small for gestational age.

    Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications.
    Tsai PY, Li SH, Chen WN, Tsai HL, Su MT., Free PMC Article

    04/28/2018
    During endoplasmic reticulum stress miR-346 activated autophagy by interrupting the association between BCL2 and BECN1 in a GSK3B-dependent manner.

    miR-346 functions as a pro-survival factor under ER stress by activating mitophagy.
    Guo J, Yang Z, Yang X, Li T, Liu M, Tang H.

    12/9/2017
    Overall, our results defined miR-346 as an oncogenic miRNA in non-small cell lung cancer, the levels of which contributed to tumor growth and invasive aggressiveness.

    MicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathway.
    Sun CC, Li SJ, Yuan ZP, Li DJ., Free PMC Article

    11/18/2017
    This misrepresentation of the effects of miR-346 in breast cancer could prove harmful by sidetracking future research. Further, clinical trials may be incorrectly directed towards lowering miR-346 without a complete and fair assessment of the internal contradictions in the data

    When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author.
    Lahiri DK, Maloney B, Sambamurti K.

    10/21/2017
    MiR-346 at diagnosis and cessation, and TRAb at cessation could serve as predictive factors for Graves' Disease relapse within 1 year after drug withdrawal

    MiR-346 and TRAb as Predicative Factors for Relapse in Graves' Disease Within One Year.
    Li J, Cai Y, Sun X, Yao D, Xia J.

    05/27/2017
    miR-346 and miR-582-3p regulate EG-VEGF-induced trophoblast invasion through repressing MMP 2 and MMP 9, and may become novel diagnostic biomarkers or therapeutic targets for EG-VEGF-related obstetric disorders. (c) 2016 BioFactors, 43(2):210-219, 2017.

    miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9.
    Su MT, Tsai PY, Tsai HL, Chen YC, Kuo PL.

    05/13/2017
    miR-346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1.

    miR-346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1.
    Yan HL, Li L, Li SJ, Zhang HS, Xu W.

    02/4/2017
    miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer

    MiR-346 promotes the biological function of breast cancer cells by targeting SRCIN1 and reduces chemosensitivity to docetaxel.
    Yang F, Luo LJ, Zhang L, Wang DD, Yang SJ, Ding L, Li J, Chen D, Ma R, Wu JZ, Tang JH.

    02/4/2017
    Ectopic expression of miR-346 promoted the A431 cell proliferation.

    MicroRNA-346 functions as an oncogene in cutaneous squamous cell carcinoma.
    Chen B, Pan W, Lin X, Hu Z, Jin Y, Chen H, Ma G, Qiu Y, Chang L, Hua C, Zou Y, Gao Y, Ying H, Lv D.

    02/4/2017
    MiR-346 depends on GRSF1 to upregulate another target gene.

    miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively.
    Song G, Wang R, Guo J, Liu X, Wang F, Qi Y, Wan H, Liu M, Li X, Tang H., Free PMC Article

    08/6/2016
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