| Golgi-resident tail-anchored proteins such as the golgins golgin-84, CASP and giantin as well as the vesicle-associated membrane-protein-associated proteins VAPA and VAPB interact with TRC40. | A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B., Free PMC Article | 07/18/2020 |
| Mutation in ASNA1 cause severe pediatric cardiomyopathy and early death. | Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy.
Verhagen JMA, van den Born M, van der Linde HC, G J Nikkels P, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, Verheijen FW, Hassel D, Hofstra RMW, Hegde RS, van Hasselt PM, van Ham TJ, van de Laar IMBH., Free PMC Article | 07/18/2020 |
| The authors conclude that the TRC40 pathway is critical for hearing and propose that otoferlin is an essential substrate of this pathway in hair cells. | Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T., Free PMC Article | 07/8/2017 |
| Asna1/TRC40 is required at a late step of herpes simplex virus type 1 infection for efficient release of mature virions to the extracellular milieu. | Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions.
Ott M, Marques D, Funk C, Bailer SM., Free PMC Article | 05/20/2017 |
| reveal unanticipated complexity in the mutual regulation of the TRC40 receptor subunits and raise the question as to the role of the excess CAML in the endoplasmic reticulum | Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR.
Colombo SF, Cardani S, Maroli A, Vitiello A, Soffientini P, Crespi A, Bram RF, Benfante R, Borgese N., Free PMC Article | 04/15/2017 |
| Emerin interacts with TRC40 in situ. | Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.
Pfaff J, Rivera Monroy J, Jamieson C, Rajanala K, Vilardi F, Schwappach B, Kehlenbach RH. | 10/29/2016 |
| The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97/FAF1 and ASNA1/transmembrane-domain recognition complex. | VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.
Baron Y, Pedrioli PG, Tyagi K, Johnson C, Wood NT, Fountaine D, Wightman M, Alexandru G., Free PMC Article | 10/4/2014 |
| Proteins bind to TRC40 and can utilise this component for their delivery to the ER membrane. | TRC40 can deliver short secretory proteins to the Sec61 translocon.
Johnson N, Vilardi F, Lang S, Leznicki P, Zimmermann R, High S., Free PMC Article | 05/11/2013 |
| PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. | Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.
Yagita Y, Hiromasa T, Fujiki Y., Free PMC Article | 04/27/2013 |
| Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. | Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.
Yamamoto Y, Sakisaka T. | 02/9/2013 |
| Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. | Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone.
Hradsky J, Raghuram V, Reddy PP, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y, Kreutz MR, Mikhaylova M., Free PMC Article | 12/10/2011 |
| The coiled-coil domain of WRB is the binding site for TRC40/Asna1. | WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.
Vilardi F, Lorenz H, Dobberstein B., Free PMC Article | 09/3/2011 |
| Asna1 is required for efficient histocompatibility (HLA) class I downregulation mediated by viral protein BNLF2a. | EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP.
Horst D, Favaloro V, Vilardi F, van Leeuwen HC, Garstka MA, Hislop AD, Rabu C, Kremmer E, Rickinson AB, High S, Dobberstein B, Ressing ME, Wiertz EJ. | 05/28/2011 |
| Asna1 can mediate membrane insertion of RAMP4 and Sec61beta without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the endoplasmic reticulum membrane. | Asna1/TRC40-mediated membrane insertion of tail-anchored proteins.
Favaloro V, Vilardi F, Schlecht R, Mayer MP, Dobberstein B. | 07/19/2010 |
| ASNA1 is a target to overcome platinum resistance in ovarian cancer | Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1.
Hemmingsson O, Nöjd M, Kao G, Naredi P. | 01/21/2010 |
| the hydrophobicity of the TA region dictates whether a precursor is delivered to the ER via the Hsp40/Hsc70 or Asna-1/TRC40-dependent route. | A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum.
Rabu C, Wipf P, Brodsky JL, High S., Free PMC Article | 01/21/2010 |
| Human ASNA1 is highly expressed in pancreatic beta cells, but not in other pancreatic endocrine cell types, and regulates insulin secretion in cultured cells. | ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.
Kao G, Nordenson C, Still M, Rönnlund A, Tuck S, Naredi P. | 01/21/2010 |
| TRC40/Asna-1 interacts posttranslationally with tail-anchored proteins in a transmembrane domain-dependent manner for delivery to a proteinaceous receptor at the endoplasmic reticulum membrane. | Identification of a targeting factor for posttranslational membrane protein insertion into the ER.
Stefanovic S, Hegde RS. | 01/21/2010 |