| NLRC5 exerts anti-endometriosis effects through inhibiting ERbeta-mediated inflammatory response. | NLRC5 exerts anti-endometriosis effects through inhibiting ERβ-mediated inflammatory response.
Guo B, Zhu H, Xiao C, Zhang J, Liu X, Fang Y, Wei B, Zhang J, Cao Y, Zhan L., Free PMC Article | 09/5/2024 |
| NLRC5 senses NAD[+] depletion, forming a PANoptosome and driving PANoptosis and inflammation. | NLRC5 senses NAD(+) depletion, forming a PANoptosome and driving PANoptosis and inflammation.
Sundaram B, Pandian N, Kim HJ, Abdelaal HM, Mall R, Indari O, Sarkar R, Tweedell RE, Alonzo EQ, Klein J, Pruett-Miller SM, Vogel P, Kanneganti TD., Free PMC Article | 07/31/2024 |
| NLRC5 Deficiency Reduces LPS-Induced Microglial Activation via Inhibition of NF-kappaB Signaling and Ameliorates Mice's Depressive-like Behavior. | NLRC5 Deficiency Reduces LPS-Induced Microglial Activation via Inhibition of NF-κB Signaling and Ameliorates Mice's Depressive-like Behavior.
Sun C, Shen Y, Liu P, Shen Y, Hu Y, Li P, Zhang Y, Miao F, Zhang J., Free PMC Article | 09/15/2023 |
| USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis. | USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
Fu Y, Qiu J, Wu J, Zhang L, Wei F, Lu L, Wang C, Zeng Z, Liang S, Zheng J. | 08/7/2023 |
| NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson's disease models. | NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson's disease models.
Liu Z, Shen C, Li H, Tong J, Wu Y, Ma Y, Wang J, Wang Z, Li Q, Zhang X, Dong H, Yang Y, Yu M, Wang J, Zhou R, Fei J, Huang F., Free PMC Article | 05/19/2023 |
| NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity. | NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
Santharam MA, Shukla A, Levesque D, Kufer TA, Boisvert FM, Ramanathan S, Ilangumaran S., Free PMC Article | 05/3/2023 |
| Expression pattern of NLRC5 in the postnatal mouse brain. | Expression pattern of NLRC5 in the postnatal mouse brain.
Hu Y, Shen Y, Wu X, Ba R, Xu H, Lu K, Shao Y, Sun C, Zhang Y, Miao F, Shen Y, Zhang J. | 10/15/2022 |
| NLRC5 modulates bone metabolism and plays a role in periodontitis. | NLRC5 modulates bone metabolism and plays a role in periodontitis.
Wang W, Liu W, Liu J, Lv P, Wang Y, Ouyang X. | 07/30/2022 |
| NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis. | NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis.
Quenum AJI, Shukla A, Rexhepi F, Cloutier M, Ghosh A, Kufer TA, Ramanathan S, Ilangumaran S., Free PMC Article | 01/22/2022 |
| Inhibition of NLRC5 regulates cytokine expression in CD4+ T helper lymphocytes and prolongs murine islet and skin allograft survival. | Inhibition of NLRC5 regulates cytokine expression in CD4+ T helper lymphocytes and prolongs murine islet and skin allograft survival.
Zhang X, Xue Z, Li Z, Ren A, Zhu X, Deng R, Ma Y. | 10/2/2021 |
| Arid2-IR promotes NF-kappaB-mediated renal inflammation by targeting NLRC5 transcription. | Arid2-IR promotes NF-κB-mediated renal inflammation by targeting NLRC5 transcription.
Zhang P, Yu C, Yu J, Li Z, Lan HY, Zhou Q., Free PMC Article | 04/3/2021 |
| Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue. | Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue.
Chonwerawong M, Ferrand J, Chaudhry HM, Higgins C, Tran LS, Lim SS, Walker MM, Bhathal PS, Dev A, Moore GT, Sievert W, Jenkins BJ, D'Elios MM, Philpott DJ, Kufer TA, Ferrero RL. | 04/3/2021 |
| NLRC5 deficiency ameliorates cardiac fibrosis in diabetic cardiomyopathy by regulating EndMT through Smad2/3 signaling pathway. | NLRC5 deficiency ameliorates cardiac fibrosis in diabetic cardiomyopathy by regulating EndMT through Smad2/3 signaling pathway.
Wang B, Wu Y, Ge Z, Zhang X, Yan Y, Xie Y. | 02/13/2021 |
| The USP14-NLRC5 pathway inhibits titanium particle-induced osteolysis in mice by suppressing NF-kappaB and PI3K/AKT activities. | The USP14-NLRC5 pathway inhibits titanium particle-induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities.
Fang G, Fu Y, Li S, Qiu J, Kuang M, Lin S, Li C, Ding Y., Free PMC Article | 12/26/2020 |
| Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity. | Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity.
Zebertavage LK, Alice A, Crittenden MR, Gough MJ., Free PMC Article | 12/5/2020 |
| NLRC5 is a key regulator of MHC I up-regulation in the developing hippocampus. | Neuronal NLRC5 regulates MHC class I expression in Neuro-2a cells and also during hippocampal development.
Li P, Shen Y, Cui P, Hu Y, Zhang Y, Miao F, Zhang A, Zhang J. | 06/27/2020 |
| NLRC5 negatively regulates lipoteichoic acid-induced inflammatory response via a TLR2/NF-kappaB pathway in macrophages and also participates in TLR2-mediated allergic airway inflammation. | NLRC5 negatively regulates LTA-induced inflammation via TLR2/NF-κB and participates in TLR2-mediated allergic airway inflammation.
Wang M, Wang L, Fang L, Li S, Liu R. | 06/6/2020 |
| Findings reveal the involvement of miRNA-34a-NLRC5-NFkappaB signaling axis in HIV-1 Tat-mediated microglial inflammation. | HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis.
Periyasamy P, Thangaraj A, Bendi VS, Buch S., Free PMC Article | 05/23/2020 |
| this study shows that NLRC5 deficiency has a moderate impact on immunodominant CD8(+) T-cell responses during rotavirus infection of adult mice | NLRC5 deficiency has a moderate impact on immunodominant CD8(+) T-cell responses during rotavirus infection of adult mice.
Sun T, Ferrero RL, Girardin SE, Gommerman JL, Philpott DJ. | 04/4/2020 |
| Compared with the normal mice, the expression level of Nlrc5 increased significantly in the fibrosis group but decreased significantly in the recovery group. Nlrc5 may play a key role in the development and reversal of hepatic fibrosis through the NF-kappaB signaling pathway. | Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway.
Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, Gao B., Free PMC Article | 01/4/2020 |
| Study using NLRC5 deficient mice found that NLRC5 exacerbated renal injury by the development of postischemic renal inflammation and the induction of tubular epithelial cell apoptosis that was associated with, at least in part, the negative regulation of CEACAM1. This suggests that NLRC5 signaling in renal parenchymal cells plays the dominant role in mediating renal damage. | NLRC5 deficiency protects against acute kidney injury in mice by mediating carcinoembryonic antigen-related cell adhesion molecule 1 signaling.
Li Q, Wang Z, Zhang Y, Zhu J, Li L, Wang X, Cui X, Sun Y, Tang W, Gao C, Ma C, Yi F. | 06/8/2019 |
| Taken together, NLRC5 promotes inflammation and fibrosis during diabetic nephropathy progression partly through the effects on NF-kappaB and TGF-beta/Smad pathways. | NLRC5 deficiency ameliorates diabetic nephropathy through alleviating inflammation.
Luan P, Zhuang J, Zou J, Li H, Shuai P, Xu X, Zhao Y, Kou W, Ji S, Peng A, Xu Y, Su Q, Jian W, Peng W. | 10/27/2018 |
| NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting alpha-SMA, Collagen I, Collagen III, TLR4/MyD88, phosphorylated IKKalpha, IkappaBalpha and NF-kappaB expression. | NLRC5 deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4/NF-κB.
Ma SR, Xie XW. | 03/24/2018 |
| NLRC5 knockout in mice exhibited greater hepatic injury after hepatic ischemia/reperfusion (I/R) injury. | Dexmedetomidine (DEX) protects against hepatic ischemia/reperfusion (I/R) injury by suppressing inflammation and oxidative stress in NLRC5 deficient mice.
Chen Z, Ding T, Ma CG. | 10/28/2017 |
| The observed increases in viral titers in NLRC5-deficient mice correlated with impaired effector CD8(+) T cell responses. Although NLRC5-deficient mice were defective at clearing the virus, they did not show an increase in morbidity or mortality following influenza virus infection because of other compensatory immune mechanisms. | Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8(+) T Cell Function and Impaired Viral Clearance.
Lupfer CR, Stokes KL, Kuriakose T, Kanneganti TD., Free PMC Article | 08/26/2017 |