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    MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

    Gene ID: 4340, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder.

    Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder.
    Cho EB, Min JH, Waters P, Jeon M, Ju ES, Kim HJ, Kim SH, Shin HY, Kang SY, Lim YM, Oh SY, Lee HL, Sohn E, Lee SS, Oh J, Kim S, Huh SY, Cho JY, Seok JM, Kim BJ, Kim BJ., Free PMC Article

    04/12/2024
    Barriers to access and unmet needs to neuromyelitis optica spectrum disorders care in an Argentinean cohort.

    Barriers to access and unmet needs to neuromyelitis optica spectrum disorders care in an Argentinean cohort.
    Tkachuk V, Balbuena Aguirre ME, Alonso R, Barboza A, Liwacki SDV, Mainella C, Rojas JI, Silva BA, Tavolini D, Zanga G, López P, Delgado Garcia G, Carnero Contentti E.

    10/23/2023
    MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.

    MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.
    Wu Q, Thakolwiboon S, Ali AS, Wang Q, Dwyer D, Fox DA, Mao-Draayer Y., Free PMC Article

    10/4/2023
    White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder.

    White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder.
    Zai G, Zai CC, Arnold PD, Richter MA, Hanna GL, Rosenberg D, Kennedy JL., Free PMC Article

    07/23/2023
    Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.

    Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.
    Eliseeva DD, Zakharova MN.

    05/5/2023
    Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination.

    Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination.
    Jayananth P, Madhumitha R, Ramya L.

    09/3/2022
    Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases.

    Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases.
    Schanda K, Peschl P, Lerch M, Seebacher B, Mindorf S, Ritter N, Probst M, Hegen H, Di Pauli F, Wendel EM, Lechner C, Baumann M, Mariotto S, Ferrari S, Saiz A, Farrell M, Leite MIS, Irani SR, Palace J, Lutterotti A, Kümpfel T, Vukusic S, Marignier R, Waters P, Rostasy K, Berger T, Probst C, Höftberger R, Reindl M., Free PMC Article

    03/5/2022
    Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.

    Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.
    Chen X, Ren Y, Zhang Y, Lu W.

    02/26/2022
    Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica.

    Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica.
    Ambika S, Durgapriyadarshini S, Padmalakshmi K, Noronha V, Arjundas D., Free PMC Article

    01/8/2022
    Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica.

    Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica.
    Ciotti JR, Eby NS, Wu GF, Naismith RT, Chahin S, Cross AH.

    07/3/2021
    An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder.

    An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder.
    Zai G, Arnold PD, Richter MA, Hanna GL, Rosenberg D, Kennedy JL., Free PMC Article

    05/8/2021
    Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody.

    Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody.
    Akaishi T, Fujimori J, Takahashi T, Misu T, Takai Y, Nishiyama S, Kaneko K, Ogawa R, Abe M, Ishii T, Aoki M, Fujihara K, Nakashima I.

    12/19/2020
    Risk factors for academic difficulties in children with myelin oligodendrocyte glycoprotein antibody-associated acute demyelinating syndromes.

    Risk factors for academic difficulties in children with myelin oligodendrocyte glycoprotein antibody-associated acute demyelinating syndromes.
    Deiva K, Cobo-Calvo A, Maurey H, De Chalus A, Yazbeck E, Husson B, Vukusic S, Serguerra C, Horellou P, Marignier R, Kidbiosep Cohort.

    12/19/2020
    The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients.

    The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients.
    Marti Fernandez I, Macrini C, Krumbholz M, Hensbergen PJ, Hipgrave Ederveen AL, Winklmeier S, Vural A, Kurne A, Jenne D, Kamp F, Gerdes LA, Hohlfeld R, Wuhrer M, Kümpfel T, Meinl E., Free PMC Article

    10/31/2020
    Study defined the major MOG Ab response present in a large cohort and correlated antibody features with clinical phenotypes to improve diagnosis, relapse prediction, and ultimately patient treatment.

    Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination.
    Tea F, Lopez JA, Ramanathan S, Merheb V, Lee FXZ, Zou A, Pilli D, Patrick E, van der Walt A, Monif M, Tantsis EM, Yiu EM, Vucic S, Henderson APD, Fok A, Fraser CL, Lechner-Scott J, Reddel SW, Broadley S, Barnett MH, Brown DA, Lunemann JD, Dale RC, Brilot F, Australasian and New Zealand MOG Study Group., Free PMC Article

    06/27/2020
    Only anti-AQP4 antibodies, and not AQP1 or MOG, appears to be a clear biomarker for NMOsd.

    Predictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorders.
    García-Miranda P, Morón-Civanto FJ, Martínez-Olivo MDM, Suárez-Luna N, Ramírez-Lorca R, Lebrato-Hernández L, Lamas-Pérez R, Navarro G, Abril-Jaramillo J, García-Sánchez MI, Casado-Chocán JL, Uclés-Sánchez AJ, Romera M, Echevarría M, Díaz-Sánchez M., Free PMC Article

    04/11/2020
    This review presents the findings regarding MOG antibodies as potential biological markers in discriminating between these different demyelinating CNS diseases, and discusses recent developments, clinical implementations, and data on immunopathogenesis of MOG antibody-associated disorders.

    Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders: Toward a New Spectrum of Inflammatory Demyelinating CNS Disorders?
    Di Pauli F, Berger T., Free PMC Article

    10/5/2019
    Citrullination of myelin oligodendrocyte glycoprotein at positions 41, 46 and/or 52 promotes amyloid-like behavior that is toxic to both dendritic cells and Epstein-Barr virus-infected B-lymphocytes.

    Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity.
    Araman C, van Gent ME, Meeuwenoord NJ, Heijmans N, Marqvorsen MHS, Doelman W, Faber BW, 't Hart BA, Van Kasteren SI., Free PMC Article

    10/5/2019
    we observed two-way correlations between the MOG and MAG levels and the fractional anisotropy and mean diffusivity values in the white matter of the left middle frontal lobe, right inferior parietal lobe, and right supplementary motor area in major depressive disorder patients

    Association between abnormal serum myelin-specific protein levels and white matter integrity in first-episode and drug-naïve patients with major depressive disorder.
    Jiang L, Cheng Y, Jiang H, Xu J, Lu J, Shen Z, Lu Y, Liu F, Li L, Xu X.

    09/1/2018
    Anti-MOG positive patients may have manifestations that mimic neuromyelitis optica spectrum disorders but differ in their course and prognosis from anti-AQP4 positive NMOSD.

    The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients.
    Siritho S, Sato DK, Kaneko K, Fujihara K, Prayoonwiwat N.

    02/3/2018
    Molecular Dynamics (MD) simulations were used to explore the interactions of MOG35-55 at the receptor level.

    Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35-55 epitope implicated in multiple sclerosis.
    Yannakakis MP, Tzoupis H, Michailidou E, Mantzourani E, Simal C, Tselios T.

    02/3/2018
    Adoptive transfer of serum from anti-MOG Ab mice or of purified anti-MOG Ab 8.18C5 into naive 2D2 recipients triggered activation and expansion of T cells followed by severe and robust experimental autoimmune encephalomyelitis, suggesting that the mechanism of anti-MOG Ab-mediated opsonization of auto-antigen may indeed contribute to initiation and propagation of CNS demyelinating disease.

    Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen.
    Kinzel S, Lehmann-Horn K, Torke S, Häusler D, Winkler A, Stadelmann C, Payne N, Feldmann L, Saiz A, Reindl M, Lalive PH, Bernard CC, Brück W, Weber MS., Free PMC Article

    12/9/2017
    Retinal nerve fiber layer may be better preserved in MOG-IgG versus AQP4-IgG optic neuritis.

    Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study.
    Stiebel-Kalish H, Lotan I, Brody J, Chodick G, Bialer O, Marignier R, Bach M, Hellmann MA., Free PMC Article

    08/12/2017
    Data show that aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG) autoantibodies double positive neuromyelitis optica spectrum disorder (NMOSD) patients had a multiphase disease course with a high annual relapse rate.

    Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD.
    Yan Y, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD., Free PMC Article

    07/22/2017
    MOG antibody associated optic neuritis tends to involve the anterior optic pathway.

    Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis.
    Ramanathan S, Prelog K, Barnes EH, Tantsis EM, Reddel SW, Henderson AP, Vucic S, Gorman MP, Benson LA, Alper G, Riney CJ, Barnett M, Parratt JD, Hardy TA, Leventer RJ, Merheb V, Nosadini M, Fung VS, Brilot F, Dale RC.

    12/24/2016
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