| Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice. | Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice.
Shi W, Chen QY, Ma Y, Wan J, Li XH, Zhuo M., Free PMC Article | 02/28/2024 |
| Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. | Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains.
Ren L, Thai PN, Gopireddy RR, Timofeyev V, Ledford HA, Woltz RL, Park S, Puglisi JL, Moreno CM, Santana LF, Conti AC, Kotlikoff MI, Xiang YK, Yarov-Yarovoy V, Zaccolo M, Zhang XD, Yamoah EN, Navedo MF, Chiamvimonvat N., Free PMC Article | 12/24/2022 |
| LncRNA H19 acts as miR-301a-3p sponge to alleviate lung injury in mice with sepsis by regulating Adcy1. | LncRNA H19 acts as miR-301a-3p sponge to alleviate lung injury in mice with sepsis by regulating Adcy1.
Hou J, He M, Chen Q, Liang S. | 08/6/2022 |
| Astrocytic cAMP modulates memory via synaptic plasticity. | Astrocytic cAMP modulates memory via synaptic plasticity.
Zhou Z, Okamoto K, Onodera J, Hiragi T, Andoh M, Ikawa M, Tanaka KF, Ikegaya Y, Koyama R., Free PMC Article | 05/15/2021 |
| results show that adenylyl cyclase 1 is a major isoform for apoA-1-activated cAMP signaling to promote cholesterol transport and exocytosis to the surface of THP-1 macrophage foam cells | Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway.
Tang W, Ma W, Ding H, Lin M, Xiang L, Lin G, Zhang Z., Free PMC Article | 07/6/2019 |
| Data show in fragile X mental retardation syndrome 1 protein (Fmr1) knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity to neuronal stimulation. | Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.
Sethna F, Feng W, Ding Q, Robison AJ, Feng Y, Wang H., Free PMC Article | 12/1/2018 |
| data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. | Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.
Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ., Free PMC Article | 11/25/2017 |
| Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety. | Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety.
Bernabucci M, Zhuo M., Free PMC Article | 11/11/2017 |
| Following ethanol administration, phosphorylation of TrkB is significantly increased in the striatum of Adcyl1 and Adcyl6 knock-out mice. | Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder.
Susick LL, Chrumka AC, Hool SM, Conti AC., Free PMC Article | 12/17/2016 |
| Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1, which defines a new signaling pathway employed by alpha7 nAChRs | Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.
Cheng Q, Yakel JL., Free PMC Article | 03/26/2016 |
| Results indicate that thalamic AC1 plays a major role in patterning and refinement of the mouse thalamocortical circuitry | Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.
Suzuki A, Lee LJ, Hayashi Y, Muglia L, Itohara S, Erzurumlu RS, Iwasato T., Free PMC Article | 12/19/2015 |
| Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice. | Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Uhl S, Mathar I, Vennekens R, Freichel M. | 04/4/2015 |
| Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing. | Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.
Santos-Cortez RL, Lee K, Giese AP, Ansar M, Amin-Ud-Din M, Rehn K, Wang X, Aziz A, Chiu I, Hussain Ali R, Smith JD, University of Washington Center for Mendelian Genomics, Shendure J, Bamshad M, Nickerson DA, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM., Free PMC Article | 01/17/2015 |
| Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor-adenylyl cyclase (AC) axis. | Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.
Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA., Free PMC Article | 06/7/2014 |
| Contrast sensitivity is similarly reduced in Adcy1-/- mice. | Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells.
Hwang CK, Chaurasia SS, Jackson CR, Chan GC, Storm DR, Iuvone PM., Free PMC Article | 11/30/2013 |
| These results suggest that AC1 in retinal ganglion cell axons mediates the development of retinotopy and eye-specific segregation in the superior colliculus and dorsal lateral geniculate nucleus. | Role of adenylate cyclase 1 in retinofugal map development.
Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, Xu HP, Jamrich M, Itohara S, Feller MB, Crair MC., Free PMC Article | 08/18/2012 |
| The lower cAMP and AC mRNA level in hippocampus might participate in the molecular pathogenesis of ischemia/ reperfusion. | [The changes of cAMP and adenylyl cyclase mRNA level in hippocampus of mice with ischemia/reperfusion].
Wang WB, Song CF, Lu PY, Yin Y, Liang CP. | 08/11/2012 |
| Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 from transcript to enzyme activity. | Dopamine D₄ receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina.
Jackson CR, Chaurasia SS, Hwang CK, Iuvone PM., Free PMC Article | 12/24/2011 |
| we have identified Adcy1 as a novel podocyte signaling protein that seems to have a role in compensatory physiological processes in the glomerulus. | Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria.
Xiao Z, He L, Takemoto M, Jalanko H, Chan GC, Storm DR, Betsholtz C, Tryggvason K, Patrakka J., Free PMC Article | 10/8/2011 |
| These results suggest a function of adenylate cyclase 1 in the formation of peripheral nerve trajectories such as branching and pruning | Adenylate Cyclase 1 modulates peripheral nerve branching patterns.
Haupt C, Langhoff J, Huber AB. | 02/12/2011 |
| The decrease in divalent calcium ion (Ca2+)-stimulated adenylyl cyclase activity during aging of wild-type mice may be an adaptive mechanism required to maintain spatial memory function. | Overexpression of type I adenylyl cyclase in the forebrain impairs spatial memory in aged but not young mice.
Garelick MG, Chan GC, DiRocco DP, Storm DR., Free PMC Article | 01/21/2010 |
| Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. | Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
Masada N, Ciruela A, Macdougall DA, Cooper DM., Free PMC Article | 01/21/2010 |
| data suggest that AC1/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome | Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brain.
Conti AC, Young C, Olney JW, Muglia LJ., Free PMC Article | 01/21/2010 |
| These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory. | Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory.
Shan Q, Chan GC, Storm DR., Free PMC Article | 01/21/2010 |
| The potential role of AC1 in mediating synaptic plasticity and regulating AMPAR trafficking during barrel map development is studied using barrelless mice, mutants without AC1 activity or cortical 'barrel' maps. | Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development.
Lu HC, She WC, Plas DT, Neumann PE, Janz R, Crair MC. | 01/21/2010 |