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    MMP12 matrix metallopeptidase 12 [ Homo sapiens (human) ]

    Gene ID: 4321, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD.

    SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD.
    Ganbold C, Jamiyansuren J, Munkhzorig E, Dashtseren I, Jav S., Free PMC Article

    06/5/2024
    Integrated Exploration of Epigenetic Dysregulation Reveals a Stemness/EMT Subtype and MMP12 Linked to the Progression and Prognosis in Hepatocellular Carcinoma.

    Integrated Exploration of Epigenetic Dysregulation Reveals a Stemness/EMT Subtype and MMP12 Linked to the Progression and Prognosis in Hepatocellular Carcinoma.
    Zuo A, Li J, Weng S, Xu H, Zhang Y, Wang L, Xing Z, Luo P, Cheng Q, Li J, Han X, Liu Z.

    05/23/2024
    HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.

    HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.
    Sun C, Deng H, Li Q, Wang P, Chen Y, Sun Y, Han C.

    05/1/2024
    MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease.

    MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease.
    Dong L, Wang Y, Chen H, Li Z, Xu X, Zhou J, Shen H, Chen Z., Free PMC Article

    03/1/2024
    Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis.

    Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis.
    Teng Y, Fu X, Zhang Q, Wang F, Liu Y, Zou Z.

    12/5/2023
    Matrix metalloproteinase -12: A marker of preeclampsia?

    Matrix metalloproteinase -12: A marker of preeclampsia?
    Yakovleva N, Saprykina D, Vasiljeva E, Bettikher O, Godzoeva A, Kazantseva T, Zazerskaya I.

    11/26/2022
    DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis.

    DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis.
    Huang TL, Chang CR, Chien CY, Huang GK, Chen YF, Su LJ, Tsai HT, Lin YS, Fang FM, Chen CH., Free PMC Article

    07/9/2022
    Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis.

    Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis.
    Zhou Y, Xu M, Gong W, Kang X, Guo R, Wen J, Zhou D, Wang M, Shi D, Jing Q., Free PMC Article

    07/2/2022
    Analytical Study Of Salivary Mmp-12 Expression In Oral Submucous Fibrosis.

    Analytical Study Of Salivary Mmp-12 Expression In Oral Submucous Fibrosis.
    Saleem Z, Shaikh AH, Majeed MM, Ahmed S, Zaman U, Siddiqui Z, Kazmi A.

    05/28/2022
    Matrix metalloproteinase 12 (MMP12) as an adverse prognostic biomarker of vascular invasion in hepatic cell carcinoma.

    Matrix metalloproteinase 12 (MMP12) as an adverse prognostic biomarker of vascular invasion in hepatic cell carcinoma.
    Guo ZY, Jiang LP.

    04/30/2022
    Matrix metalloproteinase 12 is an independent prognostic factor predicting postoperative relapse of conventional renal cell carcinoma - a short report.

    Matrix metalloproteinase 12 is an independent prognostic factor predicting postoperative relapse of conventional renal cell carcinoma - a short report.
    Beres B, Yusenko M, Peterfi L, Kovacs G, Banyai D., Free PMC Article

    03/19/2022
    Evaluation of MMP-12 expression in chronic rhinosinusitis with nasal polyposis.

    Evaluation of MMP-12 expression in chronic rhinosinusitis with nasal polyposis.
    Lygeros S, Danielides G, Kyriakopoulos GC, Grafanaki K, Tsapardoni F, Stathopoulos C, Danielides V.

    02/26/2022
    Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-beta/Akt pathway.

    Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway.
    Hung WY, Lee WJ, Cheng GZ, Tsai CH, Yang YC, Lai TC, Chen JQ, Chung CL, Chang JH, Chien MH.

    02/12/2022
    Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.

    Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.
    Cárcel-Márquez J, Cullell N, Muiño E, Gallego-Fabrega C, Lledós M, Ibañez L, Krupinski J, Montaner J, Cruchaga C, Lee JM, Gill D, Paré G, Mola-Caminal M, Roquer J, Jimenez-Conde J, Martí-Fàbregas J, Fernandez-Cadenas I.

    01/8/2022
    MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis.

    MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis.
    Lin CL, Ying TH, Yang SF, Chiou HL, Chen YS, Kao SH, Hsieh YH., Free PMC Article

    10/16/2021
    Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.

    Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.
    Piga M, Congia M, Balestrieri A, Angioni MM, Cangemi I, Cau R, Chessa E, Floris A, Figus F, Iagnocco A, Cauli A, Saba L.

    10/9/2021
    Increased MMP12 mRNA expression in induced sputum was correlated with airway eosinophilic inflammation in asthma patients: Evidence from bioinformatic analysis and experiment verification.

    Increased MMP12 mRNA expression in induced sputum was correlated with airway eosinophilic inflammation in asthma patients: Evidence from bioinformatic analysis and experiment verification.
    Du L, Chen F, Xu C, Tan W, Shi J, Tang L, Xiao L, Xie C, Zeng Z, Liang Y, Guo Y.

    09/25/2021
    Role of Matrix Metallopeptidase 12 in the Development of Hepatocellular Carcinoma.

    Role of Matrix Metallopeptidase 12 in the Development of Hepatocellular Carcinoma.
    Gao H, Zhou X, Li H, Liu F, Zhu H, Song X, Niu Z, Ni Q, Yang C, Lu J.

    09/18/2021
    THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.

    THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.
    Strelkova MI, Senatorova GS, Polyakov VV.

    09/11/2021
    The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease.

    The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease.
    Feldreich T, Nowak C, Carlsson AC, Östgren CJ, Nyström FH, Sundström J, Carrero-Roig JJ, Leppert J, Hedberg P, Giedraitis V, Lind L, Cordeiro A, Ärnlöv J.

    06/26/2021
    Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma.

    Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma.
    Saleem Z, Shaikh AH, Zaman U, Ahmed S, Majeed MM, Kazmi A, Farooqui WA., Free PMC Article

    05/1/2021
    Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.

    Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.
    Lulińska E, Gibbon A, Kaczmarczyk M, Maciejewska-Skrendo A, Ficek K, Leońska-Duniec A, Wilk M, Leźnicka K, Michałowska-Sawczyn M, Humińska-Lisowska K, Buryta R, Cięszczyk P, Maculewicz E, Czarny W, September AV, Sawczuk M., Free PMC Article

    03/20/2021
    MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.

    MMP-12 as a potential biomarker to forecast ischemic stroke in obese patients.
    Wang CY, Zhang CP, Li BJ, Jiang SS, He WH, Long SY, Tian Y.

    01/30/2021
    Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases.

    Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases.
    Abd-Elaziz K, Jesenak M, Vasakova M, Diamant Z.

    12/19/2020
    Results detected that MMP12 expression is increased in castration-resistant prostate cancer (CRPC) patients tissues, and its knockdown attenuates CRPC cell line invasion. Also, endogenous estrogen produced by aromatase upregulates MMP12 expression via ERalpha. These data suggest that upregulating MMP12 expression may be a crucial mechanism by which aromatase promotes CRPC metastasis.

    Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-α/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer.
    Liang Z, Cao J, Tian L, Shen Y, Yang X, Lin Q, Zhang R, Liu H, Du X, Shi J, Zhang J.

    05/23/2020
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