| MLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells. | MLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells.
Yang Z, Zhang G, Zhao R, Tian T, Zhi J, Wei G, Roeder RG, Jing L, Yu M., Free PMC Article | 10/23/2024 |
| Impact of MLL::AF9 Gene Rearrangement on Survival of Acute Myeloid Leukaemia Patients: An Insight into Pakistani Population. | Impact of MLL::AF9 Gene Rearrangement on Survival of Acute Myeloid Leukaemia Patients: An Insight into Pakistani Population.
Tariq M, Shahab S, Saeed JR, Hussain Z, Zaidi U, Farzana T, Ahmad S. | 04/12/2024 |
| AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription. | AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.
He X, Zhong X, Fang Y, Hu Z, Chen Z, Wang Y, Huang H, Zhao S, Li D, Wei P., Free PMC Article | 08/16/2023 |
| Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain. | Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain.
Bilgin N, Moesgaard L, Rahman MM, Türkmen VA, Kongsted J, Mecinović J., Free PMC Article | 05/5/2023 |
| The adverse impact of ecotropic viral integration site-1 (EVI1) overexpression on the prognosis of acute myeloid leukemia with KMT2A gene rearrangement in different risk stratification subtypes. | The adverse impact of ecotropic viral integration site-1 (EVI1) overexpression on the prognosis of acute myeloid leukemia with KMT2A gene rearrangement in different risk stratification subtypes.
Liu XX, Pan XA, Gao MG, Kong J, Jiang H, Chang YJ, Zhang XH, Wang Y, Liu KY, Chen Z, Zhao XS, Huang XJ. | 03/24/2023 |
| BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity. | BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.
Schmidt CR, Achille NJ, Kuntimaddi A, Boulton AM, Leach BI, Zhang S, Zeleznik-Le NJ, Bushweller JH., Free PMC Article | 03/26/2022 |
| The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer. | The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.
Kabra A, Bushweller J., Free PMC Article | 01/29/2022 |
| The Transcriptional Coactivator, ALL1-Fused Gene From Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages in Liver Cancer. | The Transcriptional Coactivator, ALL1-Fused Gene From Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages in Liver Cancer.
Yu H, He J, Liu W, Feng S, Gao L, Xu Y, Zhang Y, Hou X, Zhou Y, Yang L, Wang X. | 01/15/2022 |
| The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer. | The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer.
Tian X, Yu H, Li D, Jin G, Dai S, Gong P, Kong C, Wang X., Free PMC Article | 11/22/2021 |
| Relationships between AML1-ETO and MLL-AF9 fusion gene expressions and hematological parameters in acute myeloid leukemia. | Relationships between AML1-ETO and MLL-AF9 fusion gene expressions and hematological parameters in acute myeloid leukemia.
Muddathir ARM, Hamid TAM, Mohamed Elamin E, Khabour OF. | 08/21/2021 |
| Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness. | Characterization of Copy Number Variations in Oral Cavity Squamous Cell Carcinoma Reveals a Novel Role for MLLT3 in Cell Invasiveness.
Wang CI, Kao HK, Chen TW, Huang Y, Cheng HW, Yi JS, Hung SY, Wu CS, Lee YS, Chang KP., Free PMC Article | 09/5/2020 |
| MLLT3 thus acts as haematopoietic stem cells (HSCs) maintenance factor that links histone reader and modifying activities to modulate HSC gene expressio | MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment.
Calvanese V, Nguyen AT, Bolan TJ, Vavilina A, Su T, Lee LK, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA., Free PMC Article | 04/4/2020 |
| Based on the observation that MLL-AF9 helps to preserve the ongoing gene expression program across multiple cellular contexts, study proposes that the rapidly proliferating, immature myeloid progenitor cell state initiates transformation when this cell state is perpetuated by MLL-AF9 expression, fulfilling the functional definition of malignancy. | MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors.
Chen X, Burkhardt DB, Hartman AA, Hu X, Eastman AE, Sun C, Wang X, Zhong M, Krishnaswamy S, Guo S., Free PMC Article | 04/4/2020 |
| To study the ability of FLT3N676K to cooperate with KMT2A-MLLT3 in human leukemogenesis. | FLT3(N676K) drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis.
Hyrenius-Wittsten A, Pilheden M, Falqués-Costa A, Eriksson M, Sturesson H, Schneider P, Wander P, Garcia-Ruiz C, Liu J, Ågerstam H, Hultquist A, Lilljebjörn H, Stam RW, Järås M, Hagström-Andersson AK., Free PMC Article | 02/8/2020 |
| This system provides for rapid systematic screening of relative risk, dose dependence, and combinatorial impact of multitudes of dietary and environmental exposures on MLL-AF9 translocations | Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.
Bariar B, Vestal CG, Deem B, Goodenow D, Ughetta M, Engledove RW, Sahyouni M, Richardson C., Free PMC Article | 03/2/2019 |
| miR-564 inhibited metastasis and proliferation of prostate cancer by targeting MLLT3 | miR-564 inhibited metastasis and proliferation of prostate cancer by targeting MLLT3.
Meng FJ, Meng FM, Wu HX, Cao XF. | 07/28/2018 |
| MLL-AF9 fusion is associated with acute myeloid leukemia. | MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.
Prange KHM, Mandoli A, Kuznetsova T, Wang SY, Sotoca AM, Marneth AE, van der Reijden BA, Stunnenberg HG, Martens JHA., Free PMC Article | 10/14/2017 |
| Structural insights into H3 histone crotonyl-lysine recognition by the AF9 YEATS domain have been presented. | Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Zhang Q, Zeng L, Zhao C, Ju Y, Konuma T, Zhou MM., Free PMC Article | 10/7/2017 |
| A luciferase reporter gene assay revealed that hsp70 promoter activation is enhanced by the transcriptional co-activator AF9 and splicing mediator SNRPE, but suppressed by the coiled-coil domain-containing protein CCDC127. | Yeast Two-Hybrid and One-Hybrid Screenings Identify Regulators of hsp70 Gene Expression.
Saito Y, Nakagawa T, Kakihana A, Nakamura Y, Nabika T, Kasai M, Takamori M, Yamagishi N, Kuga T, Hatayama T, Nakayama Y. | 09/23/2017 |
| YEATS domain of AF9 directly links histone crotonylation to active transcription. | Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.
Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, Wan L, Huang H, Tang Z, Zhao Y, Roeder RG, Shi X, Allis CD, Li H., Free PMC Article | 08/5/2017 |
| Results show that human MLL-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia that expresses genes related to epithelial-mesenchymal transition. | MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome.
Stavropoulou V, Kaspar S, Brault L, Sanders MA, Juge S, Morettini S, Tzankov A, Iacovino M, Lau IJ, Milne TA, Royo H, Kyba M, Valk PJM, Peters AHFM, Schwaller J. | 03/25/2017 |
| Results show that MLL-AF9 reduces Id2 and increases E2-2 expression to drive and sustain leukemia stem cell potential in MLL-rearranged acute myeloid leukemia (AML). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL-rearranged but also t(8;21) AML patients. | Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.
Ghisi M, Kats L, Masson F, Li J, Kratina T, Vidacs E, Gilan O, Doyle MA, Newbold A, Bolden JE, Fairfax KA, de Graaf CA, Firth M, Zuber J, Dickins RA, Corcoran LM, Dawson MA, Belz GT, Johnstone RW. | 03/25/2017 |
| Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations. | Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.
Wang Q, Zheng QC, Zhang HX. | 02/18/2017 |
| Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L-mediated H3K79 methylation in transcription control. | AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.
Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X., Free PMC Article | 03/21/2015 |
| AF9 and its homolog ENL directly interact with AF4. | An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias.
Barretto NN, Karahalios DS, You D, Hemenway CS., Free PMC Article | 01/10/2015 |