| The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. | The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
Yu S, Sun Z, Ju T, Liu Y, Mei Z, Wang C, Qu Z, Li N, Wu F, Liu K, Lu M, Huang M, Pang X, Jia Y, Li Y, Zhang Y, Dou S, Jiang J, Dong X, Huang C, Li W, Zhang Y, Yuan Y, Yang B, Du W., Free PMC Article | 09/16/2024 |
| Metabolic reprogramming driven by METTL1-mediated tRNA m7G modification promotes acquired anlotinib resistance in oral squamous cell carcinoma. | Metabolic reprogramming driven by METTL1-mediated tRNA m7G modification promotes acquired anlotinib resistance in oral squamous cell carcinoma.
Chen J, Zhou Q, Li S, Ling R, Zhao Y, Chen D, Wang A, Cao Y. | 08/20/2024 |
| METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression. | METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression.
Peng W, Fu J, Zhou L, Duan H., Free PMC Article | 07/9/2024 |
| METTL1-mediated tRNA m[7]G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade. | METTL1-mediated tRNA m(7)G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade.
Du D, Zhou M, Ju C, Yin J, Wang C, Xu X, Yang Y, Li Y, Cui L, Wang Z, Lei Y, Li H, He F, He J., Free PMC Article | 06/7/2024 |
| METTL1 facilitates ameloblastoma invasive growth via MAPK signaling pathway. | METTL1 facilitates ameloblastoma invasive growth via MAPK signaling pathway.
Wang Y, Xiong G, Cai W, Tao Q. | 04/18/2024 |
| WDR4 promotes HCC pathogenesis through N[7]-methylguanosine by regulating and interacting with METTL1. | WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1.
Dong R, Wang C, Tang B, Cheng Y, Peng X, Yang X, Ni B, Li J. | 04/12/2024 |
| N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4. | N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4.
Zhang C, Cui Y. | 03/13/2024 |
| P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC. | P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.
Zhang M, Kan D, Zhang B, Chen X, Wang C, Chen S, Gao W, Yang Z, Li Y, Chen Y, Zhu S, Wen S, Niu Y, Shang Z., Free PMC Article | 08/22/2023 |
| METTL1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study. | METTL1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study.
Deng L, Hua R, Zhang Z, Zhu J, Zhang J, Cheng J, Li S, Zhou H, Liu G, He J, Fu W., Free PMC Article | 07/27/2023 |
| METTL1/WDR4-mediated tRNA m[7]G modification and mRNA translation control promote oncogenesis and doxorubicin resistance. | METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance.
Wang Z, Yu P, Zou Y, Ma J, Han H, Wei W, Yang C, Zheng S, Guo S, Wang J, Liu L, Lin S. | 06/9/2023 |
| Association of RNA m[7]G Modification Gene Polymorphisms with Pediatric Glioma Risk. | Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk.
Zhu J, Liu X, Chen W, Liao Y, Liu J, Yuan L, Ruan J, He J., Free PMC Article | 02/10/2023 |
| Structural basis of regulated m[7]G tRNA modification by METTL1-WDR4. | Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4.
Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI., Free PMC Article | 01/21/2023 |
| Structures and mechanisms of tRNA methylation by METTL1-WDR4. | Structures and mechanisms of tRNA methylation by METTL1-WDR4.
Ruiz-Arroyo VM, Raj R, Babu K, Onolbaatar O, Roberts PH, Nam Y., Free PMC Article | 01/21/2023 |
| METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma. | METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma.
Huang M, Long J, Yao Z, Zhao Y, Zhao Y, Liao J, Lei K, Xiao H, Dai Z, Peng S, Lin S, Xu L, Kuang M. | 01/14/2023 |
| METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression. | METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression.
Ma J, Han H, Huang Y, Yang C, Zheng S, Cai T, Bi J, Huang X, Liu R, Huang L, Luo Y, Li W, Lin S., Free PMC Article | 04/16/2022 |
| METTL1 promotes hepatocarcinogenesis via m(7) G tRNA modification-dependent translation control. | METTL1 promotes hepatocarcinogenesis via m(7) G tRNA modification-dependent translation control.
Chen Z, Zhu W, Zhu S, Sun K, Liao J, Liu H, Dai Z, Han H, Ren X, Yang Q, Zheng S, Peng B, Peng S, Kuang M, Lin S., Free PMC Article | 03/5/2022 |
| METTL1-mediated m(7)G modification of Arg-TCT tRNA drives oncogenic transformation. | METTL1-mediated m(7)G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI., Free PMC Article | 09/4/2021 |
| N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression. | N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.
Dai Z, Liu H, Liao J, Huang C, Ren X, Zhu W, Zhu S, Peng B, Li S, Lai J, Liang L, Xu L, Peng S, Lin S, Kuang M. | 09/4/2021 |
| METTL1-mediated m(7)G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development. | METTL1-mediated m(7)G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development.
Deng Y, Zhou Z, Ji W, Lin S, Wang M., Free PMC Article | 07/3/2021 |
| METTL1 limits differentiation and functioning of EPCs derived from human-induced pluripotent stem cells through a MAPK/ERK pathway. | METTL1 limits differentiation and functioning of EPCs derived from human-induced pluripotent stem cells through a MAPK/ERK pathway.
Deng Y, Zhou Z, Lin S, Yu B. | 01/23/2021 |
| METTL1 promotes cell proliferation and migration in HCC. METTL1 exerts oncogenic activities via suppression of PTEN signaling. | METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN.
Tian QH, Zhang MF, Zeng JS, Luo RG, Wen Y, Chen J, Gan LG, Xiong JP. | 06/27/2020 |
| METTL1 acts as a methyltransferase for a subset of internal N(7)-methylguanosine sites in mRNA. | Transcriptome-wide Mapping of Internal N(7)-Methylguanosine Methylome in Mammalian mRNA.
Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, Zhang Z, Zhang L, Hu L, Dong X, He C., Free PMC Article | 01/18/2020 |
| The results identify METTL1-dependent N7-methylation of guanosine as a new RNA modification pathway that regulates miRNA structure, biogenesis, and cell migration. | METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.
Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T., Free PMC Article | 01/18/2020 |
| tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells | tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Okamoto M, Fujiwara M, Hori M, Okada K, Yazama F, Konishi H, Xiao Y, Qi G, Shimamoto F, Ota T, Temme A, Tatsuka M., Free PMC Article | 11/21/2015 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment.
Nguyen M, Boutignon H, Mallet E, Linglart A, Guillozo H, Jehan F, Garabedian M. | 06/30/2010 |