| Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells. | Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells.
Gao K, She K, Fan J, Shao L, Ji Z. | 02/7/2024 |
| [Tumor antigen-loaded dendritic cells combined with cytokine-induced killer (CIK) enhance the killing activity of human esophageal cancer cells by promoting ASK1 activation]. | [Tumor antigen-loaded dendritic cells combined with cytokine-induced killer (CIK) enhance the killing activity of human esophageal cancer cells by promoting ASK1 activation].
Duan Z, Li H, Hu B, Li Y, Huang L. | 06/23/2023 |
| Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology. | Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology.
Shen WB, Elahi M, Wang B, Zhan M, Yang P, Yang P. | 11/26/2022 |
| Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability. | Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability.
Giri H, Srivastava AK, Naik UP., Free PMC Article | 10/1/2022 |
| Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study. | Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study.
Xie Y, Cao P, Qin Y, Wu X, Huang B, Liu K, Liu Y. | 08/13/2022 |
| Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target. | Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target.
Singh V, Huang E, Pathak V, Willard BB, Allende DS, Nagy LE., Free PMC Article | 07/30/2022 |
| Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1alpha-ASK1 signaling pathway. | Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1 signaling pathway.
Wang X, Zhang H, Zhang P, Hao S, Yang X, Zhou X. | 03/26/2022 |
| Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway. | Activation of type 4 metabotropic glutamate receptor attenuates oxygen and glucose deprivation-induced apoptosis in human neural stem cells via inhibition of ASK1-p38 signaling pathway.
Zhang Z, Wang L, Liu Y, Luan Y, Zhu K, Tian Y, Liu Y, Zheng X. | 03/26/2022 |
| Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions. | Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions.
Obsilova V, Honzejkova K, Obsil T., Free PMC Article | 01/22/2022 |
| A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis. | A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis.
Wang T, Liu Z, She Y, Deng J, Zhong Y, Zhao M, Li S, Xie D, Sun X, Hu X, Chen C. | 01/8/2022 |
| ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes. | ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes.
Fang PP, Pan CW, Lin W, Li J, Huang SS, Zhou GY, Du WJ, Li Q., Free PMC Article | 11/6/2021 |
| Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases. | Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.
Trevelyan SJ, Brewster JL, Burgess AE, Crowther JM, Cadell AL, Parker BL, Croucher DR, Dobson RCJ, Murphy JM, Mace PD. | 11/6/2021 |
| MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway. | MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway.
Dinesh P, Kalaiselvan S, Sujitha S, Rasool M. | 10/9/2021 |
| Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge. | Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge.
Miller MR, Koch SR, Choi H, Lamb FS, Stark RJ., Free PMC Article | 08/14/2021 |
| Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease. | Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease.
Morris BJ, Chen R, Donlon TA, Masaki KH, Willcox DC, Allsopp RC, Willcox BJ., Free PMC Article | 07/24/2021 |
| Redundant role of ASK1-mediated p38MAPK activation in human platelet function. | Redundant role of ASK1-mediated p38MAPK activation in human platelet function.
Sledz KM, Moore SF, Vijayaragavan V, Mallah S, Goudswaard LJ, Williams CM, Hunter RW, Hers I. | 06/12/2021 |
| Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris. | Mechanisms of Trx2/ASK1-Mediated Mitochondrial Injury in Pemphigus Vulgaris.
Wei B, Li F., Free PMC Article | 05/29/2021 |
| The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress. | The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress.
Psenakova K, Hexnerova R, Srb P, Obsilova V, Veverka V, Obsil T. | 01/23/2021 |
| these results suggest that in resting platelets ASK1 is bound to CIB1 at low Ca2+ concentrations. Agonist-induced platelet activation causes an increase in intracellular Ca2+ concentration that leads to the dissociation of CIB1 from ASK1, allowing for proper dimerization through ASK1 N-terminal coiled-coil (NCC) domains. | Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets.
Patel P, Naik MU, Golla K, Shaik NF, Naik UP., Free PMC Article | 07/11/2020 |
| The discovery of novel ASK1 inhibitors would have a wide range of applications in medical science. In-silico techniques have been successfully used in the design of some novel ASK1 inhibitors. The use of machine learning-based approaches in combination with structure-based virtual screening (SBVS) and ligand-based virtual screening (LBVS) will be helpful toward the development of potent ASK1 inhibitors | ASK1 and its role in cardiovascular and other disorders: available treatments and future prospects.
Baig MH, Baker A, Ashraf GM, Dong JJ. | 06/13/2020 |
| This review summarized experimental evidences regarding the association between ASK1 and the pathogenesis of various diseases. [review] | Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders.
Cheon SY, Cho KJ. | 05/30/2020 |
| Herein, the authors identify apoptosis signal-regulating kinase 1 (ASK1) as a suppressor of non-alcoholic steatohepatitis and fibrosis formation. | Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis.
Challa TD, Wueest S, Lucchini FC, Dedual M, Modica S, Borsigova M, Wolfrum C, Blüher M, Konrad D., Free PMC Article | 04/18/2020 |
| Increased ASK1 expression level inhibited cell migration and proliferation of gastric cancer cells. | The Elevated ASK1 Expression Inhibits Proliferation and Invasion in Gastric Cancer HGC-27 Cells.
Wan X, Shi L, Ma X, Tang H, Wu G. | 10/26/2019 |
| LATS2 interacts with ASK1 and increases ASK1-mediated signaling to promote apoptosis and activate the JNK mitogen-activated protein kinase (MAPK). | Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.
Rusnak L, Tang C, Qi Q, Mo X, Fu H., Free PMC Article | 09/21/2019 |
| Data show greater expression of apoptosis signal-regulating kinase 1 (ASK1) in airway smooth muscle (ASM) bundles of chronic obstructive pulmonary disease (COPD) lung when compared with non-COPD. | Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease.
Eapen MS, Kota A, Vindin H, McAlinden KD, Xenaki D, Oliver BG, Deshpande DA, Sohal SS, Sharma P., Free PMC Article | 08/31/2019 |