| Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations. | Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.
Zhang B, He R, Xu Z, Sun Y, Wei L, Li L, Liu Y, Guo W, Song L, Wang H, Lin Z, Ma L., Free PMC Article | 09/25/2023 |
| Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis. | Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis.
Yang C, Shi J, Wang J, Hao D, An J, Jiang J., Free PMC Article | 03/12/2022 |
| Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. | Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y. | 12/18/2021 |
| MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling. | MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.
Cai M, Huang W, Hu X, Chen A, Zhou X. | 07/31/2021 |
| Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation. | Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation.
Weng J, Yang Y, Song D, Huo R, Li H, Chen Y, Nam Y, Zhou Q, Jiao Y, Fu W, Yan Z, Wang J, Xu H, Di L, Li J, Wang S, Zhao J, Wang J, Cao Y., Free PMC Article | 07/3/2021 |
| Overexpression of MAP3K3 promotes tumour growth through activation of the NF-kappaB signalling pathway in ovarian carcinoma. | Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma.
Zhang Y, Wang SS, Tao L, Pang LJ, Zou H, Liang WH, Liu Z, Guo SL, Jiang JF, Zhang WJ, Jia W, Li F., Free PMC Article | 10/24/2020 |
| This study suggests that expression of miR-194 is down-regulated in nasopharyngeal carcinoma, and that miR-194 can directly target MAP3K3 to regulate tumor progression. Given the pivotal involvement of MAP3K3 in nasopharyngeal carcinoma development, targeting miR-194 may be a novel strategy for the treatment of nasopharyngeal carcinoma. | MiR-194 regulates nasopharyngeal carcinoma progression by modulating MAP3K3 expression.
Yin W, Shi L, Mao Y., Free PMC Article | 02/22/2020 |
| MEKK3 overexpression prevented the inhibitory effects of miR9 on the viability, migration and invasion of PC cells. | MicroRNA‑9 suppresses human prostate cancer cell viability, invasion and migration via modulation of mitogen‑activated protein kinase kinase kinase 3 expression.
Sang Z, Jiang X, Guo L, Yin G. | 08/3/2019 |
| the data revealed the novel role and target of miR505 in NSCLC cells, which may provide novel insights regarding its role in the carcinogenesis of NSCLC and its potential values for clinical applications. | miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells.
Tang H, Lv W, Sun W, Bi Q, Hao Y., Free PMC Article | 05/25/2019 |
| Its downstream target MAP3K3 could be a potential therapeutic target for NSCLC. | MiroRNA-188 Acts as Tumor Suppressor in Non-Small-Cell Lung Cancer by Targeting MAP3K3.
Zhao L, Ni X, Zhao L, Zhang Y, Jin D, Yin W, Wang D, Zhang W. | 03/16/2019 |
| Expression of MEKK2 and MEKK3 inhibits medulloblastoma cell proliferation. | MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.
Lu J, Liu L, Zheng M, Li X, Wu A, Wu Q, Liao C, Zou J, Song H., Free PMC Article | 03/2/2019 |
| MEKK3 KO reduced both EMT and cell migration, the size of 3D colonies and the percentage of CD44(+)/CD24(+)/EpCAM(+) CSC, promoter recruitment of YAP/TAZ and the expression of their target genes. | MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity.
Santoro R, Zanotto M, Carbone C, Piro G, Tortora G, Melisi D. | 05/12/2018 |
| All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain, which may mediate the intermolecular recognition between hPTTG1 and MAP3K. | Integrated in silico-in vitro characterization, identification and disruption of the intermolecular interaction between SH3 domain-containing protein kinases and human pituitary tumor-transforming gene 1.
Li Y, Li M, Min W, Han G, Wang L, Chen C, Li Z, Zhang Y, Li J, Yue Z. | 06/24/2017 |
| Polymorphisms in MAP3K3, MMP24 and IGF1R are associated with greater height and act additively on height in children of an admixed population. | Association Study of GWAS-Derived Loci with Height in Brazilian Children: Importance of MAP3K3, MMP24 and IGF1R Polymorphisms for Height Variation.
Fontenele EG, Moraes ME, d'Alva CB, Pinheiro DP, Landim SA, Barros FA, Trarbach EB, Mendonca BB, Jorge AA. | 09/17/2016 |
| MAP3K3 overexpression is an independent poor prognostic indicator in ovarian carcinoma. | MAP3K3 overexpression is associated with poor survival in ovarian carcinoma.
Jia W, Dong Y, Tao L, Pang L, Ren Y, Liang W, Jiang J, Cheng G, Zhang WJ, Yuan X, Li F. | 08/6/2016 |
| MAP3K3 may potentially not only serve as diagnostic/prognostic markers for patients with lung cancer but also provide an indicator for future investigations into immunomodulatory therapies for lung cancer. | MAP3K3 expression in tumor cells and tumor-infiltrating lymphocytes is correlated with favorable patient survival in lung cancer.
He Y, Wang L, Liu W, Zhong J, Bai S, Wang Z, Thomas DG, Lin J, Reddy RM, Ramnath N, Carrott PW, Lynch WR, Orringer MB, Chang AC, Beer DG, Chen G., Free PMC Article | 06/11/2016 |
| studies identify gain of MEKK3 signalling and KLF2/4 function as causal mechanisms for cerebral cavernous malformations pathogenesis that may be targeted to develop new CCM therapeutics | Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML., Free PMC Article | 05/14/2016 |
| High MEKK3 expression is associated with renal clear cell carcinoma. | Expression and prognostic role of MEKK3 and pERK in patients with renal clear cell carcinoma.
Chen Q, Lu HS, Gan MF, Chen LX, He K, Fan GM, Cao XQ. | 02/6/2016 |
| MEKK3 expression was significantly higher in patients with renal clear cell carcinoma than in controls. | The expression and role of MEKK3 in renal clear cell carcinoma.
Lu H, Cao X, Chen Q, Chen L, Chen L, Gan M. | 12/19/2015 |
| This study identified an NBR1-MEKK3 complex as a key regulator of JNK signaling and adipose tissue inflammation in obesity. | A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.
Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J., Free PMC Article | 05/23/2015 |
| Our finding that Verrucous venous malformation contains a MAP3K3 mutation supports our impression that this lesion is a venous anomaly. | A somatic MAP3K3 mutation is associated with verrucous venous malformation.
Couto JA, Vivero MP, Kozakewich HP, Taghinia AH, Mulliken JB, Warman ML, Greene AK., Free PMC Article | 05/16/2015 |
| MEKK3 expression was positively correlated with survivin. | MEKK3 and survivin expression in cervical cancer: association with clinicopathological factors and prognosis.
Cao XQ, Lu HS, Zhang L, Chen LL, Gan MF. | 04/11/2015 |
| Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5-ERK5 signaling. | Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K., Free PMC Article | 10/25/2014 |
| Alterations in MEKK3 expression occur in early stages of development of esophageal squamous cell carcinoma and are sustained during disease progression. | Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis.
Hasan R, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan R., Free PMC Article | 09/6/2014 |
| We provide evidence for an intimate mutual control of the IKK complex by mitogen-activated protein kinase kinase kinase 3 (MEKK3) and transforming growth factor beta activated kinase 1 (TAK1). | MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection.
Sokolova O, Maubach G, Naumann M. | 04/26/2014 |