| MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway. | MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway.
Liu X, Zhang F, Fan Y, Qiu C, Wang K. | 10/17/2024 |
| Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures. | Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures.
Jubelin C, Muñoz-Garcia J, Ollivier E, Cochonneau D, Vallette F, Heymann MF, Oliver L, Heymann D. | 03/5/2024 |
| Minichromosome Maintenance 4 Is Associated with Cancer Stemness and Poor Survival of Patients with Gastric Cancer. | Minichromosome Maintenance 4 Is Associated with Cancer Stemness and Poor Survival of Patients with Gastric Cancer.
Katsuya N, Ishikawa A, Kido A, Fukui T, Kobayashi G, Sekino Y, Uraoka N, Babasaki T, Yasui W, Sentani K, Oue N. | 06/13/2023 |
| Identification of MCM4 as a Prognostic Marker of Hepatocellular Carcinoma. | Identification of MCM4 as a Prognostic Marker of Hepatocellular Carcinoma.
Zhou H, Jiang L, Wang G, Su L, Hou L, Xue X., Free PMC Article | 01/22/2022 |
| MCM4 in human hepatocellular carcinoma: a potent prognostic factor associated with cell proliferation. | MCM4 in human hepatocellular carcinoma: a potent prognostic factor associated with cell proliferation.
Xu Y, Yang X, Si T, Yu H, Li Y, Xing W, Guo Z. | 12/4/2021 |
| MCM2, MCM4, and MCM6 labeling seems to outperform Ki67 as tools to assess cellular proliferation in breast cancer. The onset of sustained Ki67 expression occurs only in late G1 phase, while MCM can label all proliferative cells during the active phases of cell cycle | MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.
Issac MSM, Yousef E, Tahir MR, Gaboury LA., Free PMC Article | 04/25/2020 |
| High MCM4 expression is associated with lung adenocarcinoma. | Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.
Li S, Jiang Z, Li Y, Xu Y., Free PMC Article | 04/18/2020 |
| MCM4, MCM5, and MCM8 may have roles in lung adenocarcinoma prognosis with roles in regulating the cell cycle, DNA replication and other multiple biological processes and pathways | Genome-wide investigation of the clinical significance and prospective molecular mechanism of minichromosome maintenance protein family genes in patients with Lung Adenocarcinoma.
Liu K, Kang M, Liao X, Wang R., Free PMC Article | 03/14/2020 |
| siRNA of MCM4 inhibits proliferation and induces apoptosis of laryngeal squamous cell carcinoma (LSCC) cell line UMSCC 5. MCM4 mRNA is overexpressed in carcinoma tissues and correlates with male gender, smoking history and poor differentiation in Chinese LSCC patients. | Minichromosome maintenance (MCM) protein 4 overexpression is a potential prognostic marker for laryngeal squamous cell carcinoma.
Han J, Lian M, Fang J, Liu H, Wang R, Zhai J, Fan Yang Y, Fen L, Shi Q, Zhi Ma H, Sun J, Ma Z. | 10/12/2019 |
| Data suggest that MCM4 phosphorylation by CDK2 plays role in DNA replication licensing system MCM4/MCM6/MCM7; this phosphorylation interferes with MCM complex function by lowering stability of MCM complex; MCM4 is highly phosphorylated in S phase. (MCM = minichromosome maintenance complex [hexamer of components 4/6/7]; CDK2 = cyclin-dependent kinase-2) | Function of the amino-terminal region of human MCM4 in helicase activity.
Wang X, Ishimi Y. | 01/12/2019 |
| MCM4 and MCM7 expression is significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions. | MCM4 and MCM7, potential novel proliferation markers, significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma, and precancerous lesions.
Choy B, LaLonde A, Que J, Wu T, Zhou Z., Free PMC Article | 09/2/2017 |
| This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded. | An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.
Tatsumi R, Ishimi Y. | 05/20/2017 |
| We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin | HPV-type-specific response of cervical cancer cells to cisplatin after silencing replication licensing factor MCM4.
Das M, Prasad SB, Yadav SS, Modi A, Singh S, Pradhan S, Narayan G. | 04/30/2016 |
| Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4 | G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.
Ishimi Y, Irie D. | 03/19/2016 |
| Mutant p53 depletion profoundly influenced PARP1 localization and increased the level of PCNA and MCM4 proteins. | Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4.
Polotskaia A, Xiao G, Reynoso K, Martin C, Qiu WG, Hendrickson RC, Bargonetti J., Free PMC Article | 06/6/2015 |
| Of the total, the deregulation of several genes (CDK1, CDK2, CDK4, MCM2, MCM3, MCM4, EIF3a and RPN2) were potentially associated with disease development and progression. | Microarray gene expression analysis of tumorigenesis and regional lymph node metastasis in laryngeal squamous cell carcinoma.
Lian M, Fang J, Han D, Ma H, Feng L, Wang R, Yang F., Free PMC Article | 02/28/2015 |
| Mcm2-7 loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation. | The eukaryotic Mcm2-7 replicative helicase.
Vijayraghavan S, Schwacha A. | 02/22/2014 |
| Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells | Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells.
Guo Y, Fan Y, Zhang J, Chang L, Lin JD, Chen YE., Free PMC Article | 05/4/2013 |
| point mutation of MCM4 perturbs proper interaction with MCM6 to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 complex | Effect of an MCM4 mutation that causes tumours in mouse on human MCM4/6/7 complex formation.
Watanabe E, Ohara R, Ishimi Y. | 02/16/2013 |
| Mutations in MCM4/PRKDC represent a novel cause of DNA breakage and NK cell deficiency. | Recessive mutations in MCM4/PRKDC cause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair.
Casey JP, Nobbs M, McGettigan P, Lynch S, Ennis S. | 08/11/2012 |
| Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis. | Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.
Yun HJ, Hyun SK, Park JH, Kim BW, Kwon HJ. | 07/7/2012 |
| MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency | MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.
Hughes CR, Guasti L, Meimaridou E, Chuang CH, Schimenti JC, King PJ, Costigan C, Clark AJ, Metherell LA., Free PMC Article | 05/5/2012 |
| partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency | Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.
Gineau L, Cognet C, Kara N, Lach FP, Dunne J, Veturi U, Picard C, Trouillet C, Eidenschenk C, Aoufouchi S, Alcaïs A, Smith O, Geissmann F, Feighery C, Abel L, Smogorzewska A, Stillman B, Vivier E, Casanova JL, Jouanguy E., Free PMC Article | 05/5/2012 |
| higher expression in non-small cell lung cancer | Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.
Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Takeda K, Aburatani H, Oizumi S, Konishi J, Kaga K, Matsuno Y, Birrer MJ, Nishimura M, Dosaka-Akita H. | 08/6/2011 |
| MCM4 did not predict patient survival in this series of cutaneous melanomas. | Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma.
Ladstein RG, Bachmann IM, Straume O, Akslen LA., Free PMC Article | 08/23/2010 |