| Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma. | Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma.
Wang HF, Zhou XF, Zhang QM, Wu JQ, Hou JH, Xu XL, Li XM, Liu YL., Free PMC Article | 05/28/2024 |
| MBNL-dependent impaired development within the neuromuscular system in myotonic dystrophy type 1. | MBNL-dependent impaired development within the neuromuscular system in myotonic dystrophy type 1.
Tahraoui-Bories J, Mérien A, González-Barriga A, Lainé J, Leteur C, Polvèche H, Carteron A, De Lamotte JD, Nicoleau C, Polentes J, Jarrige M, Gomes-Pereira M, Ventre E, Poydenot P, Furling D, Schaeffer L, Legay C, Martinat C., Free PMC Article | 03/1/2023 |
| Cognate RNA-Binding Modes by the Alternative-Splicing Regulator MBNL1 Inferred from Molecular Dynamics. | Cognate RNA-Binding Modes by the Alternative-Splicing Regulator MBNL1 Inferred from Molecular Dynamics.
González ÀL, Fernández-Remacha D, Borrell JI, Teixidó J, Estrada-Tejedor R., Free PMC Article | 01/11/2023 |
| STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth. | STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth.
Li H, Liu P, Li D, Wang Z, Ding Z, Zhou M, Chen X, Miao M, Ding J, Lin W, Liu Y, Zha X., Free PMC Article | 10/15/2022 |
| MBNL1 and MRTF-A form a positive feedback loop in regulating the migration of esophageal cancer cells. | MBNL1 and MRTF-A form a positive feedback loop in regulating the migration of esophageal cancer cells.
Liang C, Chang Z, Luo Y, Xu Y, Chen A, Zhang T. | 10/15/2022 |
| The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa. | The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y., Free PMC Article | 09/24/2022 |
| The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers. | The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers.
Zhang Q, Wu Y, Chen J, Tan F, Mou J, Du Z, Cai Y, Wang B, Yuan C. | 07/9/2022 |
| Altered Expression of MBNL Family of Alternative Splicing Factors in Colorectal Cancer. | Altered Expression of MBNL Family of Alternative Splicing Factors in Colorectal Cancer.
Navvabi N, Kolikova P, Hosek P, Zitricky F, Navvabi A, Vycital O, Bruha J, Palek R, Rosendorf J, Liska V, Pitule P., Free PMC Article | 12/4/2021 |
| MBNL1 Suppressed Cancer Metastatic of Skin Squamous Cell Carcinoma Via by TIAL1/MYOD1/Caspase-9/3 Signaling Pathways. | MBNL1 Suppressed Cancer Metastatic of Skin Squamous Cell Carcinoma Via by TIAL1/MYOD1/Caspase-9/3 Signaling Pathways.
Chen J, Wang J, Qian J, Bao M, Zhang X, Huang Z., Free PMC Article | 11/22/2021 |
| The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism. | The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism.
Chen YS, Liu CW, Lin YC, Tsai CY, Yang CH, Lin JC., Free PMC Article | 08/21/2021 |
| [Effect of long non-coding RNA MBNL1-AS1 expression on prognosis of acute myeloid leukemia patients]. | [Effect of long non-coding RNA MBNL1-AS1 expression on prognosis of acute myeloid leukemia patients].
Xie W, Qian TT, Pang Y, Ye X, Huang WH, Zhu P, Fu L. | 04/13/2021 |
| MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway. | MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway.
Song KY, Guo XM, Wang HQ, Zhang L, Huang SY, Huo YC, Zhang G, Feng JZ, Zhang RR, Ma Y, Hu QZ, Qin XY., Free PMC Article | 03/27/2021 |
| The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness. | The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness.
Voss DM, Sloan A, Spina R, Ames HM, Bar EE., Free PMC Article | 02/6/2021 |
| A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation. | A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation.
Ray D, Yun YC, Idris M, Cheng S, Boot A, Iain TBH, Rozen SG, Tan P, Epstein DM., Free PMC Article | 09/26/2020 |
| MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia. | MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Itskovich SS, Gurunathan A, Clark J, Burwinkel M, Wunderlich M, Berger MR, Kulkarni A, Chetal K, Venkatasubramanian M, Salomonis N, Kumar AR, Lee LH., Free PMC Article | 09/5/2020 |
| Our data showed that overexpression of hsa-miR-30b-5p led to downregulation of MBNL1 in VSMCs. This process influences VSMC proliferation and might be involved in VSMC differentiation. | The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis.
Woo CC, Liu W, Lin XY, Dorajoo R, Lee KW, Richards AM, Lee CN, Wongsurawat T, Nookaew I, Sorokin V., Free PMC Article | 05/9/2020 |
| Identification of novel splicing patterns and differential gene expression in RE+/FECD- samples provides new insights and more relevant gene targets that may be protective against FECD disease in vulnerable patients with TCF4 CTG TNR expansions. | Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy.
Wieben ED, Baratz KH, Aleff RA, Kalari KR, Tang X, Maguire LJ, Patel SV, Fautsch MP., Free PMC Article | 12/28/2019 |
| MBNL1 promotes cell differentiation through regulation of alternative splicing, and we demonstrate that TRIM71 promotes embryonic splicing patterns through MBNL1 repression | The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1.
Welte T, Tuck AC, Papasaikas P, Carl SH, Flemr M, Knuckles P, Rankova A, Bühler M, Großhans H., Free PMC Article | 11/2/2019 |
| MBNL1 overexpression altered cerebral cortical responsiveness by decreasing the response in the contralateral hemisphere evoked by electrical stimulation. | Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.
Chen G, Carter RE, Cleary JD, Reid TS, Ranum LP, Swanson MS, Ebner TJ., Free PMC Article | 09/7/2019 |
| The structure of targeted RNAs is a prevalent component of the mechanism of alternative splicing regulation by MBNLs. | MBNL splicing activity depends on RNA binding site structural context.
Taylor K, Sznajder LJ, Cywoniuk P, Thomas JD, Swanson MS, Sobczak K., Free PMC Article | 08/17/2019 |
| MBNL1 is an important alternative splicing regulator during differentiation of monocytes. | Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator.
Liu H, Lorenzini PA, Zhang F, Xu S, Wong MSM, Zheng J, Roca X., Free PMC Article | 07/27/2019 |
| The knockdown of muscleblindlike 1 (MBNL1) induces epithelial-to-mesenchymal transition (EMT)-like morphological changes in the colorectal cancer (CRC) HCT-116 cells, accompanied by an enhanced cell motility, and by the downregulation of E-cadherin and the upregulation of Snail expression. Overexpression of MBNL1 suppresses EMT, characterized by the upregulation of Ecadherin and the downregulation of Snail expression. | Muscleblind‑like 1 destabilizes Snail mRNA and suppresses the metastasis of colorectal cancer cells via the Snail/E‑cadherin axis.
Tang L, Zhao P, Kong D., Free PMC Article | 05/25/2019 |
| RBFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences. | rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.
Sellier C, Cerro-Herreros E, Blatter M, Freyermuth F, Gaucherot A, Ruffenach F, Sarkar P, Puymirat J, Udd B, Day JW, Meola G, Bassez G, Fujimura H, Takahashi MP, Schoser B, Furling D, Artero R, Allain FHT, Llamusi B, Charlet-Berguerand N., Free PMC Article | 12/22/2018 |
| Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cells. We thus identify miR-23b and miR-218, and confirm that they downregulate MBNL proteins in this cell line. | miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.
Cerro-Herreros E, Sabater-Arcis M, Fernandez-Costa JM, Moreno N, Perez-Alonso M, Llamusi B, Artero R., Free PMC Article | 12/22/2018 |
| For exogenous activation of MBNL transcription, MBNL1 transcription start site T2 seems to be the most suitable target, as the ensuing pre-mRNA is susceptible to both major loops, e1 and e5, and hence, theoretically, following induction each cell in the body could reach the optimal MBNL content. | MBNL expression in autoregulatory feedback loops.
Konieczny P, Stepniak-Konieczna E, Sobczak K., Free PMC Article | 10/27/2018 |