| STS and PUDP Deletion Identified by Targeted Panel Sequencing with CNV Analysis in X-Linked Ichthyosis: A Case Report and Literature Review. | STS and PUDP Deletion Identified by Targeted Panel Sequencing with CNV Analysis in X-Linked Ichthyosis: A Case Report and Literature Review.
Park J, Cho YG, Kim JK, Kim HH., Free PMC Article | 10/30/2023 |
| Biallelic mutations in FLG, TGM1, and STS genes segregated with different types of ichthyoses in eight families of Pakistani origin. | Biallelic mutations in FLG, TGM1, and STS genes segregated with different types of ichthyoses in eight families of Pakistani origin.
Khan N, Shah K, Fozia F, Khan SA, Muhammad N, Nasir A, Ahmad I, Rehman ZU, Jan A, Muhammad N, Khan S. | 04/20/2023 |
| Structure of human placental steroid sulfatase at 2.0 angstrom resolution: Catalysis, quaternary association, and a secondary ligand site. | Structure of human placental steroid sulfatase at 2.0 angstrom resolution: Catalysis, quaternary association, and a secondary ligand site.
Ghosh D. | 02/11/2023 |
| Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes. | Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes.
Baek HS, Kwon TU, Shin S, Kwon YJ, Chun YJ., Free PMC Article | 01/29/2022 |
| A novel STS mutation and an Xp22.31 microdeletion in a Chinese family with X-linked ichthyosis. | A novel STS mutation and an Xp22.31 microdeletion in a Chinese family with X-linked ichthyosis.
Huang Y, Luo S, Zhao P, Tan L, Fu G, Zhou A, He X. | 12/11/2021 |
| Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer. | Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer.
Armstrong CM, Liu C, Liu L, Yang JC, Lou W, Zhao R, Ning S, Lombard AP, Zhao J, D'Abronzo LS, Evans CP, Li PK, Gao AC., Free PMC Article | 11/27/2021 |
| Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure. | Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure.
Lardone MC, Reyes IN, Ortiz E, Piottante A, Palma C, Ebensperger M, Castro A. | 11/6/2021 |
| Lead optimization of 4-(thio)-chromenone 6-O-sulfamate analogs using QSAR, molecular docking and DFT - a combined approach as steroidal sulfatase inhibitors. | Lead optimization of 4-(thio)-chromenone 6-O-sulfamate analogs using QSAR, molecular docking and DFT - a combined approach as steroidal sulfatase inhibitors.
R S, Mk K. | 10/16/2021 |
| Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. | Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank.
Gubb SJA, Brcic L, Underwood JFG, Kendall KM, Caseras X, Kirov G, Davies W., Free PMC Article | 08/28/2021 |
| Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. | Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank.
Brcic L, Underwood JF, Kendall KM, Caseras X, Kirov G, Davies W., Free PMC Article | 07/10/2021 |
| X-linked ichthyosis: Clinical and molecular findings in 35 Italian patients. | X-linked ichthyosis: Clinical and molecular findings in 35 Italian patients.
Diociaiuti A, Angioni A, Pisaneschi E, Alesi V, Zambruno G, Novelli A, El Hachem M. | 09/12/2020 |
| Inhibition of steroid sulfatase by the specific inhibitor STX064 recovered steroid sulfatase -induced oxygen consumption rate repression and lactic acid over-production. Steroid sulfatase expression induced by inflammatory cytokines may exacerbate pulmonary fibrosis, as HIF1alpha expression is highly increased. | Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1α and glycolytic enzymes.
Shin S, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Kim D, Chun YJ. | 05/9/2020 |
| Liver-specific STS expression exhibited markedly increased sensitivity to CEE-induced estrogenic activity in the uterus resulting from increased levels of liver-derived and circulating estrogens. | Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice.
Feng Y, Xie Y, Xu M, Li L, Selcer KW, Oberly PJ, Poloyac SM, Wang H, Li C, Dong F, Yu C, Xie W., Free PMC Article | 03/21/2020 |
| This study is useful for understanding the genetic basis of X-linked ichthyosis (XLI) in the patients studied, for extending the known mutational spectrum of STS, diagnosis of female carriers and for further application of mutation screening in the genetic counseling of this family. | A novel nonsense mutation in the STS gene in a Pakistani family with X-linked recessive ichthyosis: including a very rare case of two homozygous female patients.
Afzal S, Ramzan K, Ullah S, Wakil SM, Jamal A, Basit S, Waqar AB., Free PMC Article | 03/7/2020 |
| Increased intratumoural metabolism of oestrogens through STS is associated with significantly lower incidence of relapse and/or distant metastasis and correspondingly improved prognosis. The enrichment of STS in the HER2 overexpressing subtype is intriguing, especially given the possible role of HER-2 over-expression in endocrine resistance. | In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.
McNamara KM, Guestini F, Sauer T, Touma J, Bukholm IR, Lindstrøm JC, Sasano H, Geisler J., Free PMC Article | 06/15/2019 |
| the results obtained indicated that zebrafish Sts exhibited enzymatic characteristics comparable to the human STS, suggesting that the physiological function of STS may be conserved between zebrafish and humans. | Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase.
Kurogi K, Yoshihama M, Williams FE, Kenmochi N, Sakakibara Y, Suiko M, Liu MC., Free PMC Article | 05/18/2019 |
| The IV phenotype was exacerbated by co-inheritance of STS and FLG mutations in a Chinese family with ichthyosis. | Exacerbation of ichthyosis vulgaris phenotype by co-inheritance of STS and FLG mutations in a Chinese family with ichthyosis: a case report.
Wang X, Tan L, Shen N, Lu Y, Zhang Y., Free PMC Article | 04/20/2019 |
| Results revealed an essential role of the adipose STS in energy homeostasis in sex- and sex hormone-dependent manner. The metabolic harm of the STS transgene in male mice appeared to have resulted from increased androgen activity in the adipose tissue. The metabolic benefit of the STS transgene in female mice was accounted for by increased estrogenic activity in the adipose tissue. | Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis.
Bi Y, Jiang M, Guo W, Guan X, Xu M, Ren S, Yang D, Gaikwad NW, Selcer KW, Xie W., Free PMC Article | 03/9/2019 |
| CYP19A1 mRNA levels were lower in endometrial cancer (EC) than in controls. A novel highly sensitive and accurate protocol to assess SULT1E1 activity is presented. STS enzyme activity and the STS:SULT1E1 activity ratio seem to be lower in ECs than in controls. STS is an important route for estrogen supply in endometrial cells. | The sulfatase pathway as estrogen supply in endometrial cancer.
Cornel KMC, Delvoux B, Saya T, Xanthoulea S, Konings GFJ, Kruitwagen RPFM, Bongers MY, Kooreman L, Romano A. | 03/9/2019 |
| Polymorphisms of STS gene is associated with attention-deficit/hyperactivity disorder. | Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation.
Wang LJ, Chan WC, Chou MC, Chou WJ, Lee MJ, Lee SY, Lin PY, Yang YH, Yen CF., Free PMC Article | 11/17/2018 |
| STS is increased in preeclamptic placentas and maternal whole blood. Our data suggests that STS may affect sFlt1 secretion by regulating sFlt1-i13 transcription, and not via alterations in syncytialisation. | Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia.
Gratton AM, Ye L, Brownfoot FC, Hannan NJ, Whitehead C, Cannon P, Deo M, Fuller PJ, Tong S, Kaitu'u-Lino TJ. | 12/23/2017 |
| This study reveals that STS is a key player of steroid biosynthesis regulating the availability of circulating cholesterol. | Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency.
Sánchez-Guijo A, Neunzig J, Gerber A, Oji V, Hartmann MF, Schuppe HC, Traupe H, Bernhardt R, Wudy SA. | 11/11/2017 |
| In contrast to the situation in boys with ADHD, in healthy men, the G-allele at rs17268988 of STS is associated with enhanced cognition. | A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males.
Humby T, Fisher A, Allen C, Reynolds M, Hartman A, Giegling I, Rujescu D, Davies W., Free PMC Article | 10/28/2017 |
| miR-661 overexpression sensitized tumors to TRAIL or STS induced apoptosis in a xenograft mouse model, and these effects were attenuated by co-expression of CYC1. | MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.
Fan L, Zhu C, Qiu R, Zan P, Zheng Z, Xu T, Li G. | 06/24/2017 |
| Collectively, STS point mutations demonstrate restricted localization, causing efficient impairment of the corresponding enzyme activity, and are more unlikely to be responsible for the phenotypic heterogeneity in XLRI subjects | Two novel missense mutations of STS gene underlie X-linked recessive ichthyosis: understanding of the mutational and structural spectrum.
Oyama N, Matsuda M, Hamada T, Numata S, Teye K, Hashimoto T, Hasegawa M. | 05/6/2017 |