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    SMAD3 SMAD family member 3 [ Homo sapiens (human) ]

    Gene ID: 4088, updated on 5-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by Recruiting SMYD3 in Breast Cancer.

    ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by Recruiting SMYD3 in Breast Cancer.
    Geng W, An J, Dong K, Zhang H, Zhang X, Liu Y, Xu R, Liu Y, Huang X, Song H, Yan W, Sun A, He F, Wang J, Gao H, Tian C., Free PMC Article

    11/5/2024
    Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFbeta1-Smad3-intergin alphaV signaling axis Based on optical image diagnosis.

    Connexin 43 controls metastatic behavior in triple negative breast cancer through TGFβ1-Smad3-intergin αV signaling axis Based on optical image diagnosis.
    Fu Y, Sun X, He Q, Gu Z, Jia X, Zhuang Z.

    10/25/2024
    Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz syndrome patients provides insights into genotype-phenotype relation.

    Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz syndrome patients provides insights into genotype-phenotype relation.
    de Wagenaar NP, van den Bersselaar LM, Odijk HJHM, Stefens SJM, Reinhardt DP, Roos-Hesselink JW, Kanaar R, Verhagen JMA, Brüggenwirth HT, van de Laar IMBH, van der Pluijm I, Essers J., Free PMC Article

    10/22/2024
    SMAD3 mediates the specification of human induced pluripotent stem cell-derived epicardium into progenitors for the cardiac pericyte lineage.

    SMAD3 mediates the specification of human induced pluripotent stem cell-derived epicardium into progenitors for the cardiac pericyte lineage.
    Miyoshi Y, Lucena-Cacace A, Tian Y, Matsumura Y, Tani K, Nishikawa M, Narita M, Kimura T, Ono K, Yoshida Y.

    10/15/2024
    Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.

    Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
    Kim SH, Oh JM, Roh H, Lee KW, Lee JH, Lee WJ.,

    09/30/2024
    SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway.

    SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-β1/smad2/3 signalling pathway.
    Hu HJ, Wang XH, Zhang ZZ, Ou Y, Ning ZH, Yang JY, Huang H, Tang HF, Jiang ZS.

    09/23/2024
    CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesiondagger.

    CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesion†.
    Yan S, Ding J, Wang Z, Zhang Y, Xu Y, Jia Y, Yang J, Qiu H.

    08/20/2024
    Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats.

    Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats.
    Qiu W, Sun Q, Li N, Chen Z, Wu H, Chen Z, Guo X, Fang F.

    07/19/2024
    Exosomes derived from adipose tissue-derived stem cells alleviated H2O2-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.

    Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
    Li Y, Xiao Y, Shang Y, Xu C, Han C, Hu D, Han J, Wang H., Free PMC Article

    06/11/2024
    MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling pathway in cervical cancer.

    MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.
    Zheng H, Liu M, Shi S, Huang H, Yang X, Luo Z, Song Y, Xu Q, Li T, Xue L, Lu F, Wang J., Free PMC Article

    05/9/2024
    Investigating dysregulation of TGF-beta1/SMAD3 signaling in atopic dermatitis: a molecular and immunohistochemical analysis.

    Investigating dysregulation of TGF-β1/SMAD3 signaling in atopic dermatitis: a molecular and immunohistochemical analysis.
    Shafi T, Rasool Wani R, Hussain S, Bhat IA, Makhdoomi R, Bashir SA, Hassan I, Shah ZA.,

    04/29/2024
    TGF-beta1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma.

    TGF-β1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma.
    Ding J, Yang YY, Li PT, Ma Y, Zhang L, Zhou Y, Jin C, Li HY, Zhu YF, Liu XP, Liu ZJ, Jia HL, Liu PG, Wu J.

    04/12/2024
    Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC.

    Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC.
    Ni H, Tang S, Lu G, Niu Y, Xu J, Zhang H, Hu J, Shen HM, Wu Y, Xia D., Free PMC Article

    03/31/2024
    DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways.

    DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways.
    Chen L, Su H, Tao Z, Liang C, Liu Z, Dong Y, Zheng P, Liu Y., Free PMC Article

    03/22/2024
    Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancer.

    Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancer.
    Han F, Chen S, Zhang K, Zhang K, Wang M, Wang P., Free PMC Article

    03/18/2024
    Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.

    Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.
    Saxena G, Gallagher S, Law TD, Maschari D, Walsh E, Dudley C, Brault JJ, Consitt LA.,

    03/4/2024
    Therapeutic potential for renal fibrosis by targeting Smad3-dependent noncoding RNAs.

    Therapeutic potential for renal fibrosis by targeting Smad3-dependent noncoding RNAs.
    Gu YY, Liu XS, Lan HY.,

    02/16/2024
    The Snail signaling branch downstream of the TGF-beta/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.

    The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.
    Motizuki M, Yokoyama T, Saitoh M, Miyazawa K., Free PMC Article

    02/13/2024
    POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.

    POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.
    Yuan Y, Li Y, Wu X, Bo J, Zhang L, Zhang J, Hu Y, Chen Y, Zeng Y, Wei X, Zhang H.

    01/16/2024
    BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma.

    BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma.
    Feng Y, Cai L, Pook M, Liu F, Chang CH, Mouti MA, Nibhani R, Militi S, Dunford J, Philpott M, Fan Y, Fan GC, Liu Q, Qi J, Wang C, Hong W, Morgan H, Wang M, Sadayappan S, Jegga AG, Oppermann U, Wang Y, Huang W, Jiang L, Pauklin S., Free PMC Article

    01/3/2024
    Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease.

    Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease.
    Chen W, Caiyun L, Yang Y, Xinwei H, Nan L, Jiaming Y, Huirong Y, Kai W, Liucheng Y.

    12/27/2023
    A novel pathogenic variant located just upstream of the C-terminal Ser423-X-Ser425 phosphorylation motif in SMAD3 causing Loeys-Dietz syndrome.

    A novel pathogenic variant located just upstream of the C-terminal Ser423-X-Ser425 phosphorylation motif in SMAD3 causing Loeys-Dietz syndrome.
    Ishii S, Fujiwara T, Yagi H, Takeda N, Ando M, Yamauchi H, Inuzuka R, Taniguchi Y, Hatano M, Komuro I., Free PMC Article

    12/22/2023
    m[6]A-modified miR-143-3p inhibits epithelial mesenchymal transition in bronchial epithelial cells and extracellular matrix production in lung fibroblasts by targeting Smad3.

    m(6)A-modified miR-143-3p inhibits epithelial mesenchymal transition in bronchial epithelial cells and extracellular matrix production in lung fibroblasts by targeting Smad3.
    Wang J, Jian Q, Yan K, Yang J, Yan L, Cheng W.

    12/20/2023
    Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion.

    Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion.
    Kim JY, Hong N, Park S, Ham SW, Kim EJ, Kim SO, Jang J, Kim Y, Kim JK, Kim SC, Park JW, Kim H., Free PMC Article

    12/20/2023
    A negative feedback loop centered on SMAD3 expression in transforming growth factor beta1-induced corneal myofibroblast differentiation.

    A negative feedback loop centered on SMAD3 expression in transforming growth factor β1-induced corneal myofibroblast differentiation.
    Tang Y, Du E, Wang G, Qin F, Meng Z, Dai L, Wang Y, Ren S.

    11/16/2023
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